DNA methylation of PTEN gene promoter region is not correlated with urocystic tumorigenesis

2012 ◽  
Vol 11 (16) ◽  
Author(s):  
Xiao-Feng Sun
Keyword(s):  
Dna Methylation ◽  
Promoter Region ◽  
Gene Promoter ◽  
Pten Gene ◽  
Gene Promoter Region

Study on DNA Methylation Status of WT1 Gene in Its Promoter Region in Hematologic Neoplasm Cell Lines.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 4386-4386
Author(s):  
Ye Zhao ◽  
Zi-xing Chen ◽  
Shao-yan Hu ◽  
Jian-nong Cen
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Cell Lines ◽  
Promoter Region ◽  
U937 Cell ◽  
Methylation Status ◽  
Gene Promoter ◽  
Epigenetic Mechanism ◽  
Wt1 Gene ◽  
Gene Promoter Region

Abstract The methylation at CpG island in the promoter region of a gene is one of the important epigenetic mechanism which regulates the gene activity. To study the DNA methylation pattern of WT1 gene promoter region within hematologic neoplastic cell lines and its correlation with WT1 gene expression by using the PCR-based methods. RT-PCR and Methylation-specific PCR were performed to study the WT1 gene expression in 8226, HL-60, Jurkat, K562, KG-1, NB4, Raji, SHI-1, U266 and U937 cell lines and the DNA methylation status in promoter region of WT1 gene. After treatment of U937 cell line by 5-aza-CdR, a demethylation inducing agent, the changes of WT1 gene expression level and the methylation status in its promter region in U937 cells was determined. Our Results showed that HL-60, K562, KG-1, NB4, SHI-1 cell lines demonstrated higher level of WT1 expression, while extremely low level was found in 8226, Jurkat, Raji, U266 and U937. The DNA hypermethylation in WT1 gene promoter region was identified in 8226, Jurkat, Raji, U266 and U937 cell lines. The WT1 gene expression in U937 was markedly enhanced after treatment with 5-aza-CdR in company with the decrease of methylated level and the increase of unmethylated level in its promoter region. These results indicate that modulation of the DNA methylation in WT1 promoter region is one of the epigenetic mechanisms to regulate its expression.

DNA methylation in the androgen receptor gene promoter region in rat prostate cancers

The Prostate ◽  
2002 ◽  
Vol 52 (1) ◽  
pp. 82-88 ◽  
Author(s):  
Satoru Takahashi ◽  
Shingo Inaguma ◽  
Michihisa Sakakibara ◽  
Young-Man Cho ◽  
Shugo Suzuki ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Androgen Receptor ◽  
Promoter Region ◽  
Receptor Gene ◽  
Gene Promoter ◽  
Androgen Receptor Gene ◽  
Rat Prostate ◽  
Prostate Cancers ◽  
Gene Promoter Region

DNA methylation changes in Oct3/4 gene promoter region of HUCB-NSC in response to neural differentiation

2009 ◽  
Vol 61 (6) ◽  
pp. 1243-1244
Author(s):  
Habich Aleksandra ◽  
Golan Maciej ◽  
Klimczak-Jajor Edyta ◽  
Bany-Laszewicz Urszula ◽  
Domańska-Janik Krystyna
Keyword(s):  
Dna Methylation ◽  
Promoter Region ◽  
Neural Differentiation ◽  
Gene Promoter ◽  
Gene Promoter Region

Ankylosing spondylitis is associated with aberrant DNA methylation of IFN regulatory factor 8 gene promoter region

2019 ◽  
Vol 38 (8) ◽  
pp. 2161-2169 ◽  
Author(s):  
Mengya Chen ◽  
Meng Wu ◽  
Xingxing Hu ◽  
Jiajia Yang ◽  
Renfang Han ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Ankylosing Spondylitis ◽  
Promoter Region ◽  
Gene Promoter ◽  
Regulatory Factor ◽  
Aberrant Dna Methylation ◽  
Gene Promoter Region

GW25-e5121 Role of DNA Methylation in NET Gene Promoter Region on the Association between Depression and Hypertension

2014 ◽  
Vol 64 (16) ◽  
pp. C222-C223
Author(s):  
Meng Lin ◽  
Chen Jingzhou ◽  
Wang Jizheng ◽  
Pei Fei ◽  
Hui Rutai ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Promoter Region ◽  
Gene Promoter ◽  
Gene Promoter Region
Sign in / Sign up

Export Citation Format

Share Document