scholarly journals Angiotensin-converting enzyme gene I/D polymorphism in Pakistani systemic lupus erythematosus patients

2010 ◽  
Vol 9 (48) ◽  
pp. 8134-8138 ◽  
Author(s):  
N Hussain ◽  
G Jaffery ◽  
S Hasnain ◽  
Nasim Sabri Anjum
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Angiotensin Converting Enzyme ◽  
Lupus Erythematosus ◽  
Angiotensin Converting Enzyme Gene ◽  
Converting Enzyme ◽  
Systemic Lupus ◽  
Enzyme Gene

Angiotensin-converting enzyme gene polymorphism in Thai patients with systemic lupus erythematosus

2015 ◽  
Vol 19 (7) ◽  
pp. 693-699 ◽  
Author(s):  
Umporn Pitipakorn ◽  
Parawee Suwannalai ◽  
Objoon Trachoo ◽  
Sasivimol Rattanasiri ◽  
Sermsiri Chitphuk ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Gene Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Lupus Erythematosus ◽  
Angiotensin Converting Enzyme Gene ◽  
Converting Enzyme ◽  
Systemic Lupus ◽  
Enzyme Gene

Angiotensin-converting enzyme insertion/deletion gene polymorphism in Egyptian children with systemic lupus erythematosus: a possible relation to proliferative nephritis

Lupus ◽  
2016 ◽  
Vol 26 (7) ◽  
pp. 762-767 ◽  
Author(s):  
A Hammad ◽  
S Yahia ◽  
W Laimon ◽  
S M Hamed ◽  
A Shouma ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Nephritis ◽  
Gene Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Lupus Erythematosus ◽  
Converting Enzyme ◽  
Systemic Lupus ◽  
Ace Gene ◽  
Proliferative Lupus Nephritis ◽  
Egyptian Children

Introduction Angiotensin-converting enzyme (ACE) is crucial in the pathogenesis of systemic lupus erythematosus through angiotensin II which regulates vascular tone and endothelial functions. Objectives To study the frequency of ACE insertion/deletion (I/D) gene polymorphism in Egyptian children with systemic lupus erythematosus and its possible relation to the renal pathology in cases with lupus nephritis. Subjects and methods The frequency of ACE gene insertion/deletion polymorphism genotypes was determined in 78 Egyptian children with systemic lupus erythematosus and compared to a matched group of 140 healthy controls using polymerase chain reaction. Results The DD genotype of the ACE gene was higher in systemic lupus erythematosus patients when compared to controls ( P<0.0001; odds ratio (OR) 2.4; 95% confidence interval (CI) 1.7–3.3) and the D allele was more frequent than the I allele in systemic lupus erythematosus patients in comparison to controls ( P < 0.0001; OR = 2.2; 95% CI = (1.6–3.1). In the lupus nephritis group, the DD genotype was significantly higher in those with proliferative lupus nephritis when compared to those with non-proliferative lupus nephritis ( P = 0.02; OR = 1.45; 95% CI = 1.4–1.6). Also, patients with proliferative lupus nephritis showed a higher frequency of the D allele ( P < 0.001; OR = 1.98; 95% CI = 1.3–2.9). Conclusion The D allele and DD genotype of the ACE gene appear to be a risk factor for the susceptibility of systemic lupus erythematosus and occurrence of proliferative nephritis in Egyptian children.

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