scholarly journals Angiotensin-Converting Enzyme Gene I/D Polymorphism Is Associated With Systemic Lupus Erythematosus Susceptibility: An Updated Meta-Analysis and Trial Sequential Analysis

2018 ◽  
Vol 9 ◽  
Author(s):  
Saif Khan ◽  
Sajad A. Dar ◽  
Raju K. Mandal ◽  
Arshad Jawed ◽  
Mohd Wahid ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Sequential Analysis ◽  
Meta Analysis ◽  
Trial Sequential Analysis ◽  
Angiotensin Converting Enzyme Gene ◽  
Converting Enzyme ◽  
Systemic Lupus ◽  
Enzyme Gene ◽  
Systemic Lupus Erythematosus Susceptibility

Angiotensin-converting enzyme gene polymorphism in Thai patients with systemic lupus erythematosus

2015 ◽  
Vol 19 (7) ◽  
pp. 693-699 ◽  
Author(s):  
Umporn Pitipakorn ◽  
Parawee Suwannalai ◽  
Objoon Trachoo ◽  
Sasivimol Rattanasiri ◽  
Sermsiri Chitphuk ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Gene Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Lupus Erythematosus ◽  
Angiotensin Converting Enzyme Gene ◽  
Converting Enzyme ◽  
Systemic Lupus ◽  
Enzyme Gene

Association of MBL-2 gene polymorphisms with systemic lupus erythematosus: an updated meta-analysis and trial sequential analysis

Lupus ◽  
2020 ◽  
Vol 29 (10) ◽  
pp. 1227-1237
Author(s):  
Harishankar Mahto ◽  
Abhijit Pati ◽  
Sushil K Sahu ◽  
Hanuman Prasad Sharma ◽  
Archana Padhi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Gene Polymorphisms ◽  
Sequential Analysis ◽  
Genetic Model ◽  
Meta Analysis ◽  
Trial Sequential Analysis ◽  
Systemic Lupus ◽  
Immune Molecule ◽  
Genetic Comparison

Objectives Mannose-binding lectin (MBL), an essential innate immune molecule, enhances the opsonization process and activates the complement system. Genetic variations at the promoter and coding region of the MBL-2 gene have been associated with susceptibility to systemic lupus erythematosus (SLE); however, reports remained inconsistent. The present study performs a meta-analysis of published peer-reviewed articles to draw a definitive conclusion. Materials and Methods Published peer-reviewed articles on the association of MBL-2 gene polymorphisms and SLE were screened on various databases such as PubMed (Medline), ScienceDirect, and Google Scholar. A total of 23 eligible articles were included in the present study, comprising 3074 SLE patients and 3985 controls. Genotype and/or allele data for MBL-2 polymorphisms (A > B, A > C, A > D, A > O, Y > X and H > L) were extracted and analyzed by Comprehensive Meta-Analysis software (CMA V3.1). Results The overall analysis revealed a significant association of MBL-2 (A > O) polymorphism with a predisposition to SLE in allele contrast ( p = 0.000; OR = 1.261), homozygous ( p = 0.005; OR = 1.482), heterozygous ( p = 0.004; OR = 1.247), dominant ( p = 0.000; OR = 1.303) and recessive ( p = 0.025; OR = 1.356) genetic comparison model. Similar results were also observed in the comparison of allele and the dominant genetic model of MBL-2 (A > B) polymorphism in overall (allele: p = 0.000, OR = 1.46, dominant: p = 0.001, OR = 1.31) and in the Asian cohorts (allele: p = 0.007, OR = 1.43, dominant: p = 0.008, OR = 1.32). Interestingly, MBL-2 (Y-221X) polymorphism exhibited protection against the development of SLE in heterozygous ( p = 0.005, OR = 0.619) and dominant genetic comparison ( p = 0.01, OR = 0.672) models. Conclusions MBL-2 variants (A > O and A > B) are associated with predisposition to SLE. Conversely, promoter polymorphism (Y-221X) offers protection against SLE development.

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