scholarly journals Recurrent Aphthous Stomatitis: Treatment and Management

2021 ◽  
pp. e2021099
Author(s):  
Marco Manfredini ◽  
Stefania Guida ◽  
Matteo Giovani ◽  
Nicola Lippolis ◽  
Enrico Spinas ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Current Literature ◽  
Clinical Condition ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Cochrane Library ◽  
Clinical Appearance ◽  
Genital Area ◽  
Systemic Treatments ◽  
Associated Symptoms

Background: Recurrent aphthous stomatitis consists of the presence of abrasions or ulcerations located on mucosae (oral or genital). Objectives: The aim of this article is to review the current literature providing the main causes related to recurrent aphthous stomatitis and insights into treatment and management of this clinical condition Methods: Articles matching terms that correlated with “recurrent aphthous stomatitis” were searched on PubMed, EMBASE, and Cochrane Library and selected according to their pertinence. Results: Several forms of aphthous stomatitis have been described, based on the extent (minor, major), morphology (herpetiform), and associations to other signs (Behçet syndrome or more complex inflammatory syndromes). Topical as well as systemic treatments have been described to obtain a faster remission of the aphthosis or to reduce associated symptoms such as pain. Conclusions: Recurrent aphthous stomatitis can have a mild-to-severe clinical appearance, being mainly localized on the oral mucosa or at the level of the genital area. Different strategies have been described so far for its management and treatment.

scholarly journals RECURRENT APHTHOUS STOMATITIS RELATED TO PSYCHOLOGICAL STRESS, FOOD ALLERGY AND GERD

2019 ◽  
Vol 6 ◽  
pp. 45
Author(s):  
Rina Kartika Sari ◽  
Diah Savitri Ernawati ◽  
Bagus Soebadi
Keyword(s):  
Food Allergy ◽  
Psychological Stress ◽  
Oral Mucosa ◽  
Recurrent Aphthous Stomatitis ◽  
Predisposing Factors ◽  
Aphthous Stomatitis ◽  
Cow Milk ◽  
Esophageal Mucosa ◽  
History Of ◽  
Multiple Ulcers

Background: Recurrent Aphthous Stomatitis (RAS) is inflammation in oral mucosa characterized by recurrent single or multiple ulcers that usually affected in non keratinized mucosa. Etiology RAS is unknown but psychological stress, allergy, and gastrointestinal disease can be predisposing factors Case Management: A 23rd years old complained recurrent oral ulcer with free ulcer period for 3-5 days. The patient had a history of food allergy, GERD and psychological stress. Intraoral examination showed recurrent multiple ulcers in variation site of the mouth. DASS 42 screening showed high stress and high anxiety. Skin Prick Test showed positive allergy to kapok, beef, chicken, cow milk, white egg, duck egg, shrimp, cob fish, milkfish, chocolate, and peanut. Ulcers treated with nonsteroid antiinflammation Aloe Vera gel and stress management by reading assignment method.Discussion: Psychological stress altered the immune system so oral mucosa prone to inflammation, and make the history of GERD getting worse. Stress causes cortisol secretion that changes the imbalance of proinflammatory and antiinflammatory cytokines. Oral mucosa becomes more susceptible to hypersensitivity. In addition, stress decreased oral and esophageal mucosa resistance to GERDConclusion: RAS triggered by psychological stress, allergy, and GERD. Treatment of RAS is by elimination predisposing factors to prevent recurrence.

scholarly journals Oral Microbiota Composition and Antimicrobial Antibody Response in Patients with Recurrent Aphthous Stomatitis

2019 ◽  
Vol 7 (12) ◽  
pp. 636 ◽  
Author(s):  
Zuzana Stehlikova ◽  
Vojtech Tlaskal ◽  
Natalie Galanova ◽  
Radka Roubalova ◽  
Jakub Kreisinger ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Serum Levels ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Common Disease ◽  
Oral Microbiota ◽  
Healthy Controls ◽  
Alpha And Beta Diversity ◽  
Oral Site ◽  
Bacteria And Fungi

Recurrent aphthous stomatitis (RAS) is the most common disease of the oral mucosa, and it has been recently associated with bacterial and fungal dysbiosis. To study this link further, we investigated microbial shifts during RAS manifestation at an ulcer site, in its surroundings, and at an unaffected site, compared with healed mucosa in RAS patients and healthy controls. We sampled microbes from five distinct sites in the oral cavity. The one site with the most pronounced differences in microbial alpha and beta diversity between RAS patients and healthy controls was the lower labial mucosa. Detailed analysis of this particular oral site revealed strict association of the genus Selenomonas with healed mucosa of RAS patients, whereas the class Clostridia and genera Lachnoanaerobaculum, Cardiobacterium, Leptotrichia, and Fusobacterium were associated with the presence of an active ulcer. Furthermore, active ulcers were dominated by Malassezia, which were negatively correlated with Streptococcus and Haemophilus and positively correlated with Porphyromonas species. In addition, RAS patients showed increased serum levels of IgG against Mogibacterium timidum compared with healthy controls. Our study demonstrates that the composition of bacteria and fungi colonizing healthy oral mucosa is changed in active RAS ulcers, and that this alteration persists to some extent even after the ulcer is healed.

scholarly journals Penatalaksanaan stomatitis aftosa rekuren mayor dengan infeksi sekunder Management of major recurrent aphtous stomatitis accompanied by secondary infection

2011 ◽  
Vol 10 (1) ◽  
pp. 42
Author(s):  
Nurdiana Nurdiana ◽  
M. Jusri
Keyword(s):  
Immune Response ◽  
Oral Mucosa ◽  
Secondary Infection ◽  
Good Prognosis ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Proper Treatment ◽  
Local Immune Response

Recurrent aphthous stomatitis (RAS)is an ulcerative condition that affects the oral mucosa without evidence ofunderlying disorder. It’s characterized by the appearance of recurring round, shallow ulcerations surrounded byinflammation that mainly involves the nonkeratinized mucosa. The classification of SAR are minor, major, andherpetiform types. Although rare, secondary infection may occur. Treatment is directed to avoid local traumaticprecipitants, lessen the pain and duration of ulceration by suppressing the local immune response, and preventsecondary infection. The objective of this paper is to discuss the treatment of RAS with secondary infection, a caseof 24-year-old man with multiple large ulcers that did not heal for almost 4 weeks. The ulcers were diagnosed asmajor RAS with secondary infection, and treated with metronidazole and ciprofloxacin, healed in 2 weeks withscars. Although secondary infection will delay healing, but with proper treatment, major RAS has good prognosis.

scholarly journals Efficacy and safety of plant-based therapy on recurrent aphthous stomatitis and oral mucositis in the past decade: a systematic review

2021 ◽  
Vol 10 (2) ◽  
pp. 179-187
Author(s):  
Indah Suasani Wahyuni ◽  
Irna Sufiawati ◽  
Wipawee Nittayananta ◽  
Irma Melyani Puspitasari ◽  
Jutti Levita
Keyword(s):  
Oral Mucositis ◽  
Curcuma Longa ◽  
Aloe Vera ◽  
Recurrent Aphthous Stomatitis ◽  
Drug Formulation ◽  
Aphthous Stomatitis ◽  
Licorice Root ◽  
Mucosal Inflammation ◽  
Cochrane Library ◽  
Root Extract

Oral mucosal inflammation is one of the oral diseases causing pain and reducing the quality of human life. The types of oral mucosal inflammation that commonly found were recurrent aphthous stomatitis (RAS) and oral mucositis (OM). Anti-inflammatory drugs, both synthetic and plant-based, have been used to treat RAS and OM. Plant-based drugs have been attracted the attention of some researchers to minimize the side effects of synthetic drugs. However, a comprehensive review addressing the use of plant-based drugs for RAS and OM therapy, including drug formulation and species of plant, has not yet been reported. Here, we reported the article review of 9 publications derived from the databases of PubMed, ScienceDirect, Cochrane Library, and other additional relevant works, in order to find the effectiveness and safety of plant-based drugs for RAS and OM therapy. This review was written by following the PRISMA guidelines, and the risk of bias of the articles was evaluated using the Oxford Quality Scoring System. It was found that the effective and safe drugs for RAS therapy contained acemannan from Aloe vera and curcumin from Curcuma longa, both in an oral gel formulation. For OM therapy, drugs contained curcumin from Curcuma longa; licorice from Glycyrrhiza glabra; Aloe vera and black mulberry from Morus nigra, in soft tablet, mouthwash solution or mucoadhesive film formulation. In conclusion, the most effective and safest plant-based therapy for RAS is Acemannan 0.5% in oral gel, whereas for OM is Licorice root extract 0.18 mg in mucoadhesive film.

scholarly journals Effectiveness of Laser Therapy in the Management of Recurrent Aphthous Stomatitis: A Systematic Review

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Min Han ◽  
Hui Fang ◽  
Quan-Li Li ◽  
Ying Cao ◽  
Rong Xia ◽  
...  
Keyword(s):  
Systematic Review ◽  
Laser Treatment ◽  
Laser Therapy ◽  
Clinical Effectiveness ◽  
Healing Time ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Cochrane Library ◽  
Large Sample Size ◽  
Security Issue

Objectives. Laser therapy is a promising new treatment for patients with recurrent aphthous stomatitis (RAS). However, the clinical effect and security issue of laser therapy remain controversial. This systematic review was conducted to evaluate the clinical effectiveness and security of laser treatment in RAS patients. Methods. Five electronic databases were searched (MEDLINE (PubMed), EMBASE, ScienceDirect, the Cochrane Library, and Web of Science) to identify all studies that were about randomized controlled clinical trials, involving the effect of laser therapy in RAS patients. Conclusion. Twenty-three studies were retained for full-text analysis after screening the titles and abstracts of potential articles, but only 10 studies satisfied the inclusion criteria after the full texts were reviewed. The included studies reported a comparison of the effectiveness between the laser treatment and placebo laser therapy (or conventional drug therapy) when managing the RAS patients. It can be concluded that laser therapy has the superiority in relieving ulcer pain and shortening healing time when compared with placebo group or medical treatment group. Although laser therapy is a promising effective treatment for RAS, high-quality clinical studies with large sample size must be further performed to confirm the effectiveness of this therapy.

scholarly journals Morphofunctional peculiarities of tissue of oral cavity in chronic recurrent aphthous stomatitis with therapeutical correction

2016 ◽  
Vol 3 (3) ◽  
pp. 146-149
Author(s):  
Kovac I.V., Kravchenko L.I., Gargin V.V.
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Soft Tissues ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Histological Investigation ◽  
Ozone Therapy ◽  
Experimental Animals ◽  
Methods Of Treatment ◽  
Β Carotene

Chronic recurrent aphthous stomatitis (CRAS) belongs to the group of chronic, inflammatory, ulcerative diseases of the oral mucosa. The aim of this study was to identify the morphofunctional peculiarities in chronic recurrent aphthous stomatitis with therapeutical correction in soft tissues of the oral cavity of experimental animals in the modeling of chronic recurrent aphthous stomatitis. We performed experimental investigation for study of the morpho-functional state of tissues of the oral mucosa in CRAS and formed three groups of animals (rabbits) with different methods of treatment. Histological investigation have been performed. Conclusion of our research is that correction of tissual changes in chronic recurrent aphthous stomatitis could be obtained with application of gel with β-carotene, α-tocopherol, a mixture of vegetable oils; with ozone therapy and their combination.Keywords: chronic recurrent aphthous stomatitis, histology, experiment. АннотацияКовач И.В., Кравченко Л.И., Гаргин В.В*.Морфофункциональные особенности тканей ротовой полости при хроническом рецидивирующем афтозном стоматите с терапевтической коррекциейХронический рецидивирующий афтозный стоматит относится к группе хронических, воспалительных, язвенных заболеваний слизистой оболочки полости рта. Целью данного исследования явилось выявление морфофункциональных особенностей мягких тканей ротовой полости экспериментальных животных при моделировании хронического рецидивирующего афтозного стоматита с терапевтической коррекцией. Мы моделировали хронический рецидивирующий афтозный стоматит и изучили морфо-функциональное состояние тканей слизистой оболочки полости рта сформировав три группы животных (кроликов) с различными методами лечения. Было проведено гистологическое исследование. Вывод наших исследований заключается в том, что коррекция тканевых изменений при хроническом рецидивирующем афтозном стоматите может быть получена при применении геля с бета-каротином, альфа-токоферолом, смесью растительных масел, кроме этого при озонотерапии и комбинации указанных методов.Ключевые слова: хронический рецидивирующий афтозный стоматит, гистология, эксперимент. АнотаціяКовач І.В., Кравченко Л.І., Гаргін В.В.*Морфофункціональні особливості тканин ротової порожнини при хронічному рецидивуючому афтозний стоматит з терапевтичної корекцією Хронічний рецидивний афтозний стоматит відноситься до групи хронічних, запальних, виразкових захворювань слизової оболонки порожнини рота. Метою даного дослідження було виявлення морфофункціональних особливостей м'яких тканин ротової порожнини експериментальних тварин при моделюванні хронічного рецидивуючого афтозного стоматиту з терапевтичної корекцією. Ми моделювали хронічний рецидивний афтозний стоматит і вивчали морфо-функціональний стан тканин слизової оболонки порожнини рота сформувавши три групи тварин (кроликів) з різними методами лікування. Було проведено гістологічне дослідження. Висновок наших досліджень полягає в тому, що корекція тканинних змін при хронічному рецидивуючому афтозному стоматит може бути отримана при застосуванні гелю з бета-каротином, альфа-токоферолом, сумішшю рослинних масел, крім цього при озонотерапії та комбінації вказаних методів.Ключові слова: хронічний рецидивуючий афтозний стоматит, гістологія, експеримент.

scholarly journals SUBSTANTIATION OF DIAGNOSIS AND TREATMENT OF CHRONIC RECURRENT APHTHOUS STOMATITIS IN CROHN’S DISEASE

2020 ◽  
Vol 73 (3) ◽  
pp. 512-516
Author(s):  
Oksana Y. Feleshtynska ◽  
Olena O. Dyadyk
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Oral Mucosa ◽  
Morphological Study ◽  
Comparison Group ◽  
Granulomatous Inflammation ◽  
Main Group ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Diagnosis And Treatment

The aim: To substantiate the diagnosis and treatment of chronic recurrent aphthous stomatitis in Crohn’s disease. Materials and methods: The analysis of diagnostic and treatment of 52 patients with chronic recurrent aphthous stomatitis in Crohn’s disease (main group), mean age 31.8 + 2.3 was performed. The comparison group consisted of 50 patients with chronic recurrent aphthous stomatitis not associated with Crohn’s disease (mean age 34.7 + 1.8). Patients in both groups were studied for clinical manifestations, morphological and immunohistochemical studies the aphthae on the oral mucosa were performed. Results: An objective evaluation of the oral mucosa showed that the aphthae on the oral mucosa in patients of both groups did not differ visually. In the morphological study, the patients in the main group had granulomatous inflammation of the oral mucosa, characteristic of Crohn’s disease, while the patients in the comparison group had fibrinous inflammation. Immunohistochemical study of the cell infiltrate phenotype in the area of the lesion revealed that the patients in the main group there prevailed CD68+macrophages, the appearance of both intraepithelial and cell infiltrates of T-lymphocyte suppressors, which is characteristic of Crohn’s disease. Conclusions: Diagnosis of chronic recurrent aphthous stomatitis in Crohn’s disease is based on biopsy of the aphthae on the oral mucosa and their morphological examination, the results of which confirm the presence of granulomatous inflammation, with a large number of macrophages, the presence of T-lymphocytes, characteristic of Crohn’s disease, while recurrent aphthous stomatitis of another genesis morphologically detect fibrinous inflammation. The choice of therapeutic tactics for chronic recurrent aphthous stomatitis depends on the results of the morphological study. When granulomatous inflammation is detected in patients with chronic recurrent aphthous stomatitis, which is characteristic of Crohn’s disease, in addition to topical treatment of the oral mucosa, specific therapy with mesalazine drugs is prescribed.

scholarly journals Treatment of recurrent aphthous stomatitis by laser therapy: A systematic review of the literature

2015 ◽  
Vol 72 (8) ◽  
pp. 722-728 ◽  
Author(s):  
Verica Pavlic ◽  
Vesna Vujic-Aleksic ◽  
Akira Aoki ◽  
Lana Nezic
Keyword(s):  
Laser Therapy ◽  
Treatment Options ◽  
Healing Process ◽  
Cochrane Collaboration ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Cochrane Library ◽  
Original Research ◽  
Treatment Protocols ◽  
Efficient Treatment

Background/Aim. Recurrent aphthous stomatitis (RAS) is defined as multifactor immunologic inflammatory lesions in the oral cavity, characterized by painful, recurrent single/multiple, shallow, round or ovoid ulcerations of mucosal tissues. To date, a considerable number of RAS treatment protocols have been suggested, but since the etiology of RAS is idiopathic, these treatment options have symptomatic rather than curative or preventive effect. Recently, it has been suggested that laser therapy could be successfully used as an efficient treatment approach in therapy of RAS. Therefore, the aim of this review was to estimate the effects of laser therapy in treatment of RAS analyzing results of clinical studies published in peer reviewed journals. Methods. The studies published until 31 December 2013 were obtained from the Medline/PubMed, Science Direct and Cochrane Library of the Cochrane Collaboration (CENTRAL) online databases, using following search terms and key words: ?laser? AND ?recurrent aphthous stomatitis?, ?laser? AND ?aphthous?, and ?laser? AND ?aphthae?. In total 4 original research articles met the all required inclusion/exclusion criteria, and were used for this review. The main outcome measures assessed were: a reduction of pain associated with RAS and a reduction in episode duration (faster RAS healing). Results. The assessed literature demonstrates the benefits of laser therapy mainly due to immediate analgesia and ability to speed up a RAS healing process. Conclusion. Even though the assessed literature suggests beneficial outcomes of laser therapy in treatment of RAS, these results should be interpreted with caution. The issues related to the study designs and different sets of laser irradiation parameters of a limited number of available studies with the same treatment outcomes prevent us from making definite conclusions.

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