scholarly journals Inconclusive evidence on systemic treatments for recurrent aphthous stomatitis

2012 ◽  
Vol 13 (4) ◽  
pp. 120-120 ◽  
Author(s):  
Silvia Spivakovsky
Keyword(s):  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Systemic Treatments

scholarly journals Recurrent Aphthous Stomatitis: Treatment and Management

2021 ◽  
pp. e2021099
Author(s):  
Marco Manfredini ◽  
Stefania Guida ◽  
Matteo Giovani ◽  
Nicola Lippolis ◽  
Enrico Spinas ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Current Literature ◽  
Clinical Condition ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Cochrane Library ◽  
Clinical Appearance ◽  
Genital Area ◽  
Systemic Treatments ◽  
Associated Symptoms

Background: Recurrent aphthous stomatitis consists of the presence of abrasions or ulcerations located on mucosae (oral or genital). Objectives: The aim of this article is to review the current literature providing the main causes related to recurrent aphthous stomatitis and insights into treatment and management of this clinical condition Methods: Articles matching terms that correlated with “recurrent aphthous stomatitis” were searched on PubMed, EMBASE, and Cochrane Library and selected according to their pertinence. Results: Several forms of aphthous stomatitis have been described, based on the extent (minor, major), morphology (herpetiform), and associations to other signs (Behçet syndrome or more complex inflammatory syndromes). Topical as well as systemic treatments have been described to obtain a faster remission of the aphthosis or to reduce associated symptoms such as pain. Conclusions: Recurrent aphthous stomatitis can have a mild-to-severe clinical appearance, being mainly localized on the oral mucosa or at the level of the genital area. Different strategies have been described so far for its management and treatment.

scholarly journals Genetic and immunologic findings in children with recurrent aphthous stomatitis with systemic inflammation

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Martina Girardelli ◽  
Erica Valencic ◽  
Valentina Moressa ◽  
Roberta Margagliotta ◽  
Alessandra Tesser ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Systemic Inflammation ◽  
Lupus Erythematosus ◽  
Early Onset ◽  
Disease Onset ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Monogenic Disorders ◽  
Pathogenic Variants ◽  
Targeted Treatments

Abstract Background Recurrent aphthous stomatitis with systemic signs of inflammation can be encountered in inflammatory bowel disease, Behçet’s disease (BD), Systemic Lupus Erythematosus (SLE). In addition, it has been proposed that cases with very early onset in childhood can be underpinned by rare monogenic defects of immunity, which may require targeted treatments. Thus, subjects with early onset recurrent aphthous stomatitis receiving a clinical diagnosis of BD-like or SLE-like disease may deserve a further diagnostic workout, including immunologic and genetic investigations. Objective To investigate how an immunologic, genetic and transcriptomics assessment of interferon inflammation may improve diagnosis and care in children with recurrent aphthous stomatitis with systemic inflammation. Methods Subjects referred to the pediatric rheumatologist for recurrent aphthous stomatitis associated with signs of systemic inflammation from January 2015 to January 2020 were enrolled in the study and underwent analysis of peripheral lymphocyte subsets, sequencing of a 17-genes panel and measure of interferon score. Results We enrolled 15 subjects (12 females, median age at disease onset 4 years). The clinical diagnosis was BD in 8, incomplete BD in 5, BD/SLE overlap in 1, SLE in 1. Pathogenic genetic variants were detected in 3 patients, respectively 2 STAT1 gain of function variants in two patients classified as BD/SLE overlap and SLE, and 1 TNFAIP3 mutation (A20 haploinsufficiency) in patients with BD. Moreover 2 likely pathogenic variants were identified in DNASE1L3 and PTPN22, both in patients with incomplete BD. Interferon score was high in the two patients with STAT1 GOF mutations, in the patient with TNFAIP3 mutation, and in 3 genetic-negative subjects. In two patients, the treatment was modified based on genetic results. Conclusions Although recurrent aphthous stomatitis associated with systemic inflammation may lead to a clinical diagnosis of BD or SLE, subjects with early disease onset in childhood deserve genetic investigation for rare monogenic disorders. A wider genetic panel may help disclosing the genetic background in the subset of children with increased interferon score, who tested negative in this study.

Results of Double-Blind Placebo-Controlled Challenge with Nickel Salts in Patients Affected by Recurrent Aphthous Stomatitis

2003 ◽  
Vol 131 (4) ◽  
pp. 296-300 ◽  
Author(s):  
M.L. Pacor ◽  
G. Di Lorenzo ◽  
N. Martinelli ◽  
G. Lombardo ◽  
A. Di Gregoli ◽  
...  
Keyword(s):  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Double Blind ◽  
Double Blind Placebo

Recurrent aphthous stomatitis (RAS): a preliminary within-subject study of quality of life, oral health impacts and personality profiles

2014 ◽  
Vol 44 (4) ◽  
pp. 278-283 ◽  
Author(s):  
Mahmoud K. AL-Omiri ◽  
Jumana Karasneh ◽  
Mohannad M. Alhijawi ◽  
Abdalwhab M. A. Zwiri ◽  
Crispian Scully ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Health Impacts ◽  
Personality Profiles

scholarly journals Validation of anamnestic diagnostic criteria for recurrent aphthous stomatitis

2012 ◽  
Vol 42 (4) ◽  
pp. 290-294 ◽  
Author(s):  
Lorena Baccaglini ◽  
Douglas W. Theriaque ◽  
Jonathan J. Shuster ◽  
Giselle Serrano ◽  
Rajesh V. Lalla
Keyword(s):  
Diagnostic Criteria ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis
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