scholarly journals The Relationship of Serum Heat Shock Protein 70 Antibody Levels with the Inflammatory Factors and Serum Uric Acid Levels in Hemodialysis Patients

2019 ◽  
Vol 21 (6) ◽  
Author(s):  
Neda Haghighat ◽  
Majid Mohammadshahi ◽  
Shokouh Shayanpour
Keyword(s):  
Uric Acid ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Serum Uric Acid ◽  
Heat Shock Protein 70 ◽  
Hemodialysis Patients ◽  
Inflammatory Factors ◽  
Antibody Levels ◽  
Relationship Of ◽  
The Relationship

Relationship between heat shock protein 70 and B amyloids in patients with alzheimer disease and vascular dementia

2011 ◽  
Vol 26 (S2) ◽  
pp. 505-505
Author(s):  
Y. Fu ◽  
S. Xiao
Keyword(s):  
Heat Shock ◽  
Alzheimer Disease ◽  
Heat Shock Protein ◽  
Vascular Dementia ◽  
Heat Shock Protein 70 ◽  
High Plasma ◽  
Enzyme Linked Immunosorbent Assay ◽  
Statistical Manual ◽  
The Relationship ◽  
Normal Controls

AimsExplore the relationship between levels of plasma Aβ1–40, Aβ1–42 and heat shock protein 70 (HSP70) in patients with Alzheimer disease (AD) and vascular dementia (VD) and in elderly non-demented controls.Methods23 patients with AD and 21 patients with VD who meet diagnostic criteria of the Diagnostic Statistical Manual 4th edition and 20 control subjects were enrolled, administered the Mini-Mental State Exam (MMSE) and the Activity of Daily Living (ADL) inventory and their levels of plasma Aβ1–40, Aβ1–42 and HSP70 were measured by sandwich enzyme-linked immunosorbent assay.ResultsThe levels of plasma Aβ1–40, Aβ1–42 and the Aβ1–40/Aβ1–42 ratio were not significantly different across groups, but levels of plasma HSP70 in VD patients was significantly higher than in AD patients and in normal controls (3.19 vs 1.91 vs 1.43ng/ml, respectively; F=6.464, P=0.003). In the AD group MMSE scores were inversely correlated with ADL scores (r=-0.617, P=0.002) and with levels of plasma HSP70 (r=-0.437, P=0.037); but HSP70 levels were positively correlated with age (r=0.616, P=0.002) and with plasma Aβ1–40 (r=0.497, P=0.016) in AD group. In the VD group levels of plasma HSP70 were positively correlated with plasma Aβ1–40 (r=0.436, P=0.048).ConclusionsOur findings provide further evidence that high plasma HSP70 levels may play a role in the diagnosis and differential diagnosis of AD. HSP70 levels in AD patients is inversely associated with cognitive performance and positively correlated with plasma Aβ1–40. Plasma HSP70 in VD patients is significantly elevated and positively correlated with plasma Aβ1–40.

scholarly journals Heat Shock Protein 70 and Anti-heat Shock Protein 70 Antibodies in Nasal Secretions of Patients with Chronic Rhinosinusitis

2016 ◽  
Vol 7 (1) ◽  
pp. ar.2016.7.0149 ◽  
Author(s):  
Namjil N. Tsybikov ◽  
Elena V. Egorova ◽  
Boris I. Kuznik ◽  
Elena V. Fefelova ◽  
Eli Magen
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Chronic Rhinosinusitis ◽  
Heat Shock Protein 70 ◽  
Nasal Polyps ◽  
Immunoglobulin E ◽  
Clinical Severity ◽  
Secretory Iga ◽  
Enzyme Linked Immunosorbent Assay ◽  
Antibody Levels

Background The issue of heat shock protein (HSP) 70 and anti-HSP70 antibodies in chronic rhinosinusitis (CRS) has never been explored. Objective To determine the nasal secretion (NS) levels of HSP70 and anti-HSP70 antibodies in patients with CRS with nasal polyps (CRSwNP) and patients with CRS without nasal polyps (CRSsNP), and to evaluate their associations with CRS clinical severity and correlation with NS interleukin (IL), IL-5 and interferon λ. Methods CRS severity was determined by Lund-Mackay scores. Levels of immunoglobulin E (IgE), IL-4, IL-5, interferon A, HSP70, and anti-HSP70 antibody levels in NS were measured by enzyme-linked immunosorbent assay. Results Forty-six patients with CRSsNP (25 women [543%] and 21 men [45.7%], mean [standard deviation {SD}]) age, 34.1 ± 123 years; 54 patients with CRSwNP (24 women [44.4%] and 30 men [55.6%], mean [SD] age, 37.9 ± 17.5 years). A group of 40 healthy subjects served as controls. Compared with the controls (with a mean [SD] NS HSP70 level of 0.05 ± 0.03 μg/mL), mean [SD]NS HSP70 levels in both the CRSsNP group (0.16 ± 0.07 ixg/mL) and CRSwNP group (0.21 ± 0.10 μg/mL) were increased (p < 0.001). Similarly, the mean (SD) NS anti-HSP70 antibody levels were significantly higher in patients with CRSwNP (0.25 ± 0.09 optical density value [ODV]) compared with CRSsNP (0.13 ± 0.04 ODV) (p < 0.001) and healthy controls (0.14 ± 0.02 ODV) (p < 0.001). NS HSP70 in subjects with CRSwNP showed a significant positive correlation with the Lund-Mackay score (r = 0.31; p < 0.05). NS levels of either HSP70 or anti-HSP70 antibodies were strongly correlated with NS IL-4 in the CRSwNP group (r = 0.62, p < 0.001; and r = 0.69, p < 0.001, respectively). Conclusion NS concentrations of HSP70 and secretory IgA anti HSP70 antibodies are increased in CRSwNP (but not in CRSsNP) and correlate positively with the Lund-Mackay score, NS IL-4, and NS IL-5.

The Relationship of the Hypertension, Insulin Resistance, and Metabolic Syndrome in the Serum Uric Acid Level

2004 ◽  
Vol 34 (9) ◽  
pp. 874 ◽  
Author(s):  
Tae Woo Yoo ◽  
Ki Chul Sung ◽  
Young Choon Kim ◽  
Sang Tai Hwang ◽  
Se Yong Oh ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Relationship Of ◽  
The Relationship

THE RELATIONSHIP OF SERUM URIC ACID TO SUBCLINICAL BLOOD LEAD

Rheumatology ◽  
1981 ◽  
Vol 20 (4) ◽  
pp. 208-210 ◽  
Author(s):  
MICHAEL D. BAKER ◽  
JOHN R. JOHNSTON ◽  
ALLAN E. MACLATCHY ◽  
BASIL N. BEZUIDENHOUT
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Blood Lead ◽  
Relationship Of ◽  
The Relationship

Relationship Between Serum Uric Acid Levels and Non-alcoholic Fatty Liver Disease in the Non-Obese Chinese Population: A Secondary Analysis Based on A Cross-Sectional Study

2021 ◽  
Author(s):  
Shengqiang Gao ◽  
Kuvaneshan Ramen ◽  
Shian Yu ◽  
Jiansheng Luo
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Chinese Population ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Relationship Of ◽  
The Relationship ◽  
Alcoholic Fatty Liver Disease

Abstract Background: Non-alcoholic fatty liver disease (NAFLD) is linked to some metabolic disorders. Herein, we explored the relationship of levels of serum uric acid （SUA）with NAFLD in a population of non-obese Chinese. Methods: This was a cross-sectional study that involved 183,903 Chinese men and women with an average age of 40.98 years who underwent physical examinations at a health screening center at Wenzhou People’s Hospital. We defined NAFLD by ultrasound detection of steatosis. We employed univariate analysis along with multivariate Cox proportional hazards analyses to investigate the relationship of SUA level with NAFLD. Moreover, we employed the receiver operating characteristic curve to establish the SUA cutoffs of estimating NAFLD. Results: Overall, 25,501 participants (13.9%) had NAFLD. The NAFLD ORs were 1.47 (95% CI 1.35 to 1.59), 2.01 (95% CI 1.85 to 2.18) and 2.77 (95% CI 2.55 to 3.02) compared with Q1.AUC values for SUA ratios was 0.728. The optimal SUA level cut-off value for identification of NAFLD was 287.5, with a specificity and a sensitivity of 60.7% and 73.9%, respectively.Conclusion: High Serum uric acid levels shows positive correlation with NAFLD. SUA constitutes a cheap, simple, non-invasive, as well as a beneficial biomarker that could be utilized to forecast NAFLD in the non-obese Chinese population.

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