scholarly journals The Oncolytic Effect of Respiratory Syncytial Virus (RSV) in Human Skin Cancer Cell Line, A431

2013 ◽  
Vol 15 (1) ◽  
pp. 62-7 ◽  
Author(s):  
Vahid Salimi ◽  
Masoumeh Tavakoli Yaraki ◽  
Mahmood Mahmoodi ◽  
Shahram Shahabi ◽  
Mohammad Javad Gharagozlou ◽  
...  
Molecules ◽  
2017 ◽  
Vol 22 (11) ◽  
pp. 1940 ◽  
Author(s):  
Laetitia Nivelle ◽  
Jane Hubert ◽  
Eric Courot ◽  
Nicolas Borie ◽  
Jean-Hugues Renault ◽  
...  

2021 ◽  
Vol 12 (1) ◽  
pp. 729-733
Author(s):  
Deepa Suruli ◽  
Fathima Bushra Sheriff Mirza ◽  
Gloria Jemmi Christobel R ◽  
Amuthavalli Kottaiswamy ◽  
Shila Samuel ◽  
...  

Naringin is a citrus flavonoid recently studied for anti-inflammatory activity in numerous cancer cells. In this study, the anti-inflammatory properties of naringin along with 5-fluorouracil in human skin cancer cell lines A375 was analyzed. A375 cells were treated with naringin, 5-fluorouracil alone, and combination. MTT assay and cell viability assays was demonstrated to detect the inhibitory effects of naringin or 5-fluorouracil on cell proliferation. mRNA expression of TNFα, IL-6, IL-1β, and NFκB were determined using quantitative RT-PCR.  The effect of naringin and 5-fluorouracil combination significantly inhibited the growth and proliferation of the A375 cells in a concentration dependent manner with the IC50 values of naringin (24.75 μM) 5-fluorouracil (2.5 μM). The combination of naringin+5-fluorouracil on A375 cell lines at a concentration of half IC50 values (12µM+1 μM). Naringin and 5-fluorouracil combination also decreased the level of TNFα, IL-6, IL-1β, and NFκB mRNA in the A375 cell line. Naringin and 5-fluorouracil exerted anti-inflammatory effect through the suppression of NF-kB, IL-1β, TNFα, IL-6 in A375 cells. Taken together, our results suggested that treating A375 with naringin and 5-fluorouracil combination may have future applications in treating skin cancers through its anti-inflammatory effect.


2020 ◽  
Vol 3 (3) ◽  
Author(s):  
Natsumi Uehara ◽  
Naoki Otsuki ◽  
Mie Kubo ◽  
Junko Kitamoto ◽  
Yasutaka Kojima ◽  
...  

2014 ◽  
Vol 3 (1) ◽  
pp. 27-30 ◽  
Author(s):  
Phil-Sang Chung ◽  
Jin-Chul Ahn ◽  
Sang Joon Lee ◽  
Peijie HE ◽  
Jeong Hwan Moon

2001 ◽  
Vol 120 (5) ◽  
pp. A336-A336
Author(s):  
M SHIMADA ◽  
A ANDOH ◽  
Y ARAKI ◽  
Y FUJIYAMA ◽  
T BAMBA

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