scholarly journals Cytotoxicity of Labruscol, a New Resveratrol Dimer Produced by Grapevine Cell Suspensions, on Human Skin Melanoma Cancer Cell Line HT-144

Molecules ◽  
2017 ◽  
Vol 22 (11) ◽  
pp. 1940 ◽  
Author(s):  
Laetitia Nivelle ◽  
Jane Hubert ◽  
Eric Courot ◽  
Nicolas Borie ◽  
Jean-Hugues Renault ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Skin ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Cell Suspensions ◽  
Skin Melanoma ◽  
Melanoma Cancer

scholarly journals ROS-Mediated Necrosis by Glycolipid Biosurfactants on Lung, Breast, and Skin Melanoma Cells

2021 ◽  
Vol 11 ◽  
Author(s):  
Farazul Haque ◽  
Mohd Sajjad Ahmad Khan ◽  
Naif AlQurashi
Keyword(s):  
Cell Line ◽  
Anticancer Drugs ◽  
Cancer Cell ◽  
Biological Activities ◽  
Mouse Skin ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Skin Melanoma ◽  
Cancer Etiology ◽  
New Anticancer Drugs

Cancer is one of the major leading causes of death worldwide. Designing the new anticancer drugs is remained a challenging task due to ensure complexicity of cancer etiology and continuosly emerging drug resistance. Glycolipid biosurfactants are known to possess various biological activities including antimicrobial, anticancer and antiviral properties. In the present study, we sought to decipher the mechanism of action of the glycolipids (lactonic-sophorolipd, acidic-sophorolipid, glucolipid, and bolalipid) against cancer cells using lung cancer cell line (A549), breast cancer cell line (MDA-MB 231), and mouse skin melanoma cell line (B16F10). Scratch assay and fluorescence microscopy revealed that glycolipids inhibit tumorous cell migration possibly by inhibiting actin filaments. Fluorescence activated cell sorter (FACS) analysis exhibited that lactonic sophorolipid and glucolipid both induced the reactive oxygen species, altered the mitochondrial membrane potential (ΔΨ) and finally led to the cell death by necrosis. Furthermore, combinatorial effect of lactonic-sophorolipd and glucolipid demonstrated synergistic interaction on A549 cell line whereas additive effect on MDA-MB 231 and B16F10 cell lines. Our study has highlighted that lactonic-sophorolipd and glucolipid could be useful for developing new anticancer drugs either alone or in combination.

scholarly journals The Oncolytic Effect of Respiratory Syncytial Virus (RSV) in Human Skin Cancer Cell Line, A431

2013 ◽  
Vol 15 (1) ◽  
pp. 62-7 ◽  
Author(s):  
Vahid Salimi ◽  
Masoumeh Tavakoli Yaraki ◽  
Mahmood Mahmoodi ◽  
Shahram Shahabi ◽  
Mohammad Javad Gharagozlou ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Skin Cancer ◽  
Cell Line ◽  
Human Skin ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Syncytial Virus ◽  
Oncolytic Effect

Photodynamic Therapy Activity of Phthalocyanine-Silver Nanoparticles on Melanoma Cancer Cells

2020 ◽  
Vol 20 (5) ◽  
pp. 3097-3104 ◽  
Author(s):  
Phindile Khoza ◽  
Ivy Ndhundhuma ◽  
Aletta Karsten ◽  
Tebello Nyokong
Keyword(s):  
Silver Nanoparticles ◽  
Photodynamic Therapy ◽  
Cell Line ◽  
Cancer Cell ◽  
Red Light ◽  
Cancer Cell Line ◽  
Melanoma Cancer ◽  
Photodynamic Activity ◽  
High Degree

The synthesis, characterization and photodynamic therapy activity of a novel metal free phthalocyanine (complex 3), with or without silver nanoparticles (AgNPs), are reported. The in vitro photodynamic activity of this complex was investigated using metastatic melanoma cancer cell line. In the presence of different concentrations of complex 3 or 3 in combination with silver nanoparticles, the viability of the cells showed a concentration dependent decrease upon irradiation with red light. The photodynamic activity of complex 3 showed an increase in the presence of the AgNPs. Although complex showed a high degree of aggregation in water, it still demonstrated reasonable potency towards the melanoma cancer cell line.

Benzo[d]imidazol-5-yl)-5-(substituted)-1,3,4-Oxadiazoles: Synthesis, Anticancer, Antimicrobial and In Silico Studies

2019 ◽  
Vol 16 (9) ◽  
pp. 994-1005 ◽  
Author(s):  
Naveen Kumar ◽  
Swamy Sreenivasa ◽  
Bhuvanesh Sukhlal Kalal ◽  
Vasantha Kumar ◽  
Bantwal Shivarama Holla ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cell Line ◽  
Cancer Cell ◽  
In Silico ◽  
Cancer Cell Line ◽  
Diffusion Method ◽  
Future Research ◽  
Melanoma Cancer ◽  
In Silico Studies ◽  
A375 Melanoma

Background: Cancer is a fatal disease for mankind; continuous research is still going on for the invention of potent anticancer drugs. In this view, 1, 3, 4-Oxadiazoles are privileged molecules which attracted medicinal chemists towards their anticancer properties. Methods: A new series of benzo[d]imidazol-5-yl)-5-(substituted)-1,3,4-oxadiazole derivatives was synthesized in an efficient ‘one-pot’ nitro reductive cyclization using sodium dithionite as a cyclizing agent by a conventional method with good yield. All the structures of the synthesized molecules were characterized by IR, 1H NMR, HRMS and Mass spectral analysis. Anticancer activity screening against A375 melanoma cancer cell line and MDA-MB-231 breast cancer cell line along with antimicrobial activity were carried out using agar well diffusion method. Results: Compounds 8a and 8j of the series emerged as potent anticancer agents against A375 melanoma cancer cell line with IC50 47.06 µM and 36.76 µM, respectively. In silico studies also revealed that compounds 8a and 8j showed highest interaction with 2OH4 protein of VEGFR-2 tyrosine kinase. Substantial antibacterial and antifungal activities against the tested microorganism were observed for compounds 8j and 8g. Conclusion: Potent anticancer property has been observed with 1,3,4-Oxadiazole linked tetrafluro substituted benzene ring 8j indicating that future research on these type of molecules can be continued to improve the anticancer activity.

scholarly journals Investigating the effect of near infrared photo thermal therapy folic acid conjugated gold nano shell on melanoma cancer cell line A375

2019 ◽  
Vol 47 (1) ◽  
pp. 2161-2170 ◽  
Author(s):  
Fateme Sadat Majidi ◽  
Elham Mohammadi ◽  
Bita Mehravi ◽  
Samira Nouri ◽  
Khadije Ashtari ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cell Line ◽  
Cancer Cell ◽  
Near Infrared ◽  
Cancer Cell Line ◽  
Thermal Therapy ◽  
Melanoma Cancer

Ligation of fas antigen stimulates chemoline secretion in pancreatic cancer cell line PANC-1

2001 ◽  
Vol 120 (5) ◽  
pp. A336-A336
Author(s):  
M SHIMADA ◽  
A ANDOH ◽  
Y ARAKI ◽  
Y FUJIYAMA ◽  
T BAMBA
Keyword(s):  
Pancreatic Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Pancreatic Cancer Cell Line ◽  
Cancer Cell Line ◽  
Fas Antigen

624: Usefulness of Cancer Vaccine Therapy Using Bladder Cancer Cell Line Introduced with Interleukin 21 Gene

2006 ◽  
Vol 175 (4S) ◽  
pp. 201-201 ◽  
Author(s):  
Isao Hara ◽  
Junya Furukawa ◽  
Kazuki Yamanaka ◽  
Yuji Yamada ◽  
Masato Fujisawa
Keyword(s):  
Bladder Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Vaccine ◽  
Cancer Cell Line ◽  
Bladder Cancer Cell ◽  
Vaccine Therapy ◽  
Bladder Cancer Cell Line ◽  
Interleukin 21
Sign in / Sign up

Export Citation Format

Share Document