Oral Ibuprofen versus Intravenous Ibuprofen or Intravenous Indomethacin for the Treatment of Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis

Neonatology ◽  
2012 ◽  
Vol 102 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Roland Neumann ◽  
Sven M. Schulzke ◽  
Christoph Bührer
Keyword(s):  
Systematic Review ◽  
Patent Ductus Arteriosus ◽  
Preterm Infants ◽  
Meta Analysis ◽  
Ductus Arteriosus ◽  
Oral Ibuprofen ◽  
Intravenous Ibuprofen ◽  
Patent Ductus

Use of ibuprofen for the closure of patent ductus arteriosus in preterm infants: a systematic review of meta-analyses

2021 ◽  
Author(s):  
Samaher Al-Shaibi ◽  
Dina Abushanab ◽  
Eilan Alhersh ◽  
Rasha Kaddoura ◽  
Abdul Rouf Pallivalappila ◽  
...  
Keyword(s):  
Systematic Review ◽  
Patent Ductus Arteriosus ◽  
Preterm Infants ◽  
Ductus Arteriosus ◽  
Dosage Forms ◽  
Risk Of Bias ◽  
High Dose ◽  
Oral Ibuprofen ◽  
Meta Analyses ◽  
Patent Ductus

Aim: To systematically review ibuprofen, including versus indomethacin and paracetamol/acetaminophen, for the closure of patent ductus arteriosus (PDA). Methods: Pubmed, Embase, Cochrane and gray literature were searched to summarize ibuprofen outcomes in closure of PDA in published meta-analyses (MAs). Results: Seven MAs were included. Including high dose (HD) use, ibuprofen is equivalent/superior to indomethacin, and inferior/equivalent to paracetamol. Oral ibuprofen had higher efficacy than IV ibuprofen, including compared with indomethacin and paracetamol. Ibuprofen had safety advantages over indomethacin. Indomethacin and paracetamol had safety advantages over IV ibuprofen. HD of ibuprofen increases efficacy, but not toxicity. Conclusion: Evidence on ibuprofen effectiveness and safety, including the dosage forms, is limited by heterogeneity in doses and the levels of methods quality and risk of bias.

scholarly journals Corrigendum: Platelet Counts and Patent Ductus Arteriosus in Preterm Infants: An Updated Systematic Review and Meta-Analysis

2021 ◽  
Vol 9 ◽  
Author(s):  
Gema González-Luis ◽  
Stefano Ghirardello ◽  
Pilar Bas-Suárez ◽  
Giacomo Cavallaro ◽  
Fabio Mosca ◽  
...  
Keyword(s):  
Systematic Review ◽  
Patent Ductus Arteriosus ◽  
Preterm Infants ◽  
Meta Analysis ◽  
Ductus Arteriosus ◽  
Platelet Counts ◽  
Patent Ductus

scholarly journals Platelet Counts and Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis

Neonatology ◽  
2015 ◽  
Vol 108 (2) ◽  
pp. 143-151 ◽  
Author(s):  
Sorina R. Simon ◽  
Lieke van Zogchel ◽  
Maria Pilar Bas-Suárez ◽  
Giacomo Cavallaro ◽  
Ronald I. Clyman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Patent Ductus Arteriosus ◽  
Preterm Infants ◽  
Meta Analysis ◽  
Ductus Arteriosus ◽  
Platelet Counts ◽  
Patent Ductus
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