scholarly journals The Impact of Obstructive Sleep Apnea-Hypopnea Syndrome on T-Lymphocyte Subgroups and Natural Killer Cell Activity in the Peripheral Blood of Children

2020 ◽  
Vol 30 (6) ◽  
Author(s):  
Lili Huang ◽  
Yimin Chen ◽  
Jiarong Wang ◽  
Liansheng Qiu
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
T Lymphocyte ◽  
Cellular Immunity ◽  
Peripheral Blood ◽  
Nk Cell ◽  
Cell Activity ◽  
Nk Cell Activity ◽  
Obstructive Sleep ◽  
Hypopnea Syndrome

Background: Obstructive sleep apnea-hypopnea syndrome (OSAHS) can impact multiple organ systems in children. Objectives: To investigate the effects of OSAHS on T-lymphocyte subgroups and natural killer (NK) cell activity in the peripheral blood of affected children. Methods: A total of 85 children with OSAHS were enrolled into an experimental group (OSAHS) and 76 healthy children were placed in a control group (CON) to compare peripheral blood levels of CD3+, CD4+, CD8+, and NK cell activity using flow cytometry. Meanwhile, their polysomnography results were monitored to analyze the correlation between T-lymphocyte subgroups/NK cell activity and lowest pulse oxygen saturation (LSaO2)/apnea-hypopnea index (AHI). Results: Compared to the CON group, the CD3+ percentage in the OSAHS group showed no significant difference (65.98 ± 6.54 vs 64.36 ± 5.32; P > 0.05), but the CD4+ percentage, CD4+/CD8+ ratio, and NK cell activity decreased markedly (33.52 ± 3.04 vs 35.26 ± 3.68,1.29 ± 0.14 vs 1.43 ± 0.26, and 11.47 ± 4.58 vs 12.69 ± 2.36, respectively; P < 0.05). In addition, the CD8+ percentage increased significantly (26.18 ± 4.76 vs 24.36 ± 2.32; P < 0.05). Linear regression analysis indicated that the CD3+ percentage was not related to LSaO2/AHI (P > 0.05), but the CD4+ and CD8+ percentages, CD4+/CD8+ ratio, and NK cell activity were linearly related to LSaO2 and AHI (P < 0.05). Conclusions: OSAHS can affect the cellular immunity of children. The AHI and LSaO2 may be involved in cellular immunity function.

scholarly journals OSAHS in adolescents: clinical presentation and differential diagnosis

2018 ◽  
Vol 21 (1) ◽  
pp. 106
Author(s):  
N. Beydon
Keyword(s):  
Obstructive Sleep Apnea ◽  
Differential Diagnosis ◽  
Sleep Apnea ◽  
Clinical Presentation ◽  
Transitional Period ◽  
Alternative Diagnosis ◽  
Obstructive Sleep ◽  
Hypopnea Syndrome

Adolescent experiment widespread changes as he/ she goes through this transitional period from childhood to adulthood. Sleep is no exception to this changeover with, as consequences, modifications of the clinical pre- sentation of subjects with Obstructive Sleep Apnea- Hypopnea Syndrome (OSAHS) and potential different alternative diagnosis.

scholarly journals Comparisons of Thyroid Hormone, Intelligence, Attention, and Quality of Life in Children with Obstructive Sleep Apnea Hypopnea Syndrome before and after Endoscopic Adenoidectomy

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Hui-Wei Feng ◽  
Tao Jiang ◽  
Hong-Ping Zhang ◽  
Zhe Wang ◽  
Hai-Ling Zhang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Thyroid Hormone ◽  
Intelligence Quotient ◽  
Obstructive Sleep ◽  
Significant Difference ◽  
Before And After ◽  
Hypopnea Syndrome

Objective. The aim of this study was to compare the differences in thyroid hormone, intelligence, attention, and quality of life (QoL) of children with obstructive sleep apnea hypopnea syndrome (OSAHS) before and after endoscopic adenoidectomy.Method. A total of 35 OSAHS children (21 males and 14 females with a mean age of6.81±1.08years) were included in this study for analyzing the levels of thyroid hormone, intelligence, attention, and QoL. There were 22 children underwent endoscopic adenoidectomy with bilateral tonsillectomy (BT), while the other 13 children who underwent endoscopic adenoidectomy without bilateral tonsillectomy without BT.Results. Our results revealed no significant difference in serum free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels in OSAHS children before and after endoscopic adenoidectomy (allP>0.05). However, there were significant differences in full-scale intelligence quotient (FIQ) (92.45±5.88versus106.23±7.39,P<0.001), verbal intelligence quotient (VIQ) (94.17±15.01versus103.91±9.74,P=0.006), and performance intelligence quotient (PIQ) (94.12±11.04versus104.31±10.05,P=0.001), attention (98.48±8.74versus106.87±8.58,P<0.001), and total OSA-18 scores (87.62±17.15versus46.61±10.15,P<0.001) between before and after endoscopic adenoidectomy in OSAHS children.Conclusion. Our findings provided evidence that the intelligence, attention, and QoL of OSAHS children may be significantly improved after endoscopic adenoidectomy.

Endothelial Function of Patients with Morbid Obesity Submitted to Roux-en-Y Gastric Bypass With and Without Obstructive Sleep Apnea-Hypopnea Syndrome

2018 ◽  
Vol 28 (11) ◽  
pp. 3595-3603 ◽  
Author(s):  
Ana Cristina de Assunção Machado ◽  
Antonio Marcos Vargas da Silva ◽  
Luis Ulisses Signori ◽  
Glauco da Costa Alvarez ◽  
Claudio Corá Mottin
Keyword(s):  
Morbid Obesity ◽  
Obstructive Sleep Apnea ◽  
Gastric Bypass ◽  
Sleep Apnea ◽  
Endothelial Function ◽  
Obstructive Sleep ◽  
Hypopnea Syndrome

Association of prepro-orexin polymorphism with obstructive sleep apnea/hypopnea syndrome

2012 ◽  
Vol 33 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Weihu Chen ◽  
Jingying Ye ◽  
Demin Han ◽  
Guoping Yin ◽  
Boxuan Wang ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep ◽  
Hypopnea Syndrome
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