scholarly journals Development of an In-House TaqMan Real Time RT-PCR Assay to Quantify Hepatitis C Virus RNA in Serum and Peripheral Blood Mononuclear Cells in Patients With Chronic Hepatitis C Virus Infection

2015 ◽  
Vol 15 (8) ◽  
Author(s):  
Bahman Khalvati Fahlyani ◽  
Abbas Behzad-Behbahani ◽  
Seiied Alireza Taghavi ◽  
Ali Farhadi ◽  
Saeede Salehi ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Mononuclear Cells ◽  
Hepatitis C Virus Infection ◽  
Rt Pcr ◽  
Hepatitis C Virus Rna ◽  
Pcr Assay ◽  
Peripheral Blood Mononuclear ◽  
Virus Rna ◽  
Chronic Hepatitis C Virus

scholarly journals Delayed Viral Clearance after 6-Week Treatment with Peginterferon Plus Ribavirin in a Patient with Chronic Hepatitis C Virus Genotype 1b

2016 ◽  
Vol 10 (2) ◽  
pp. 417-422 ◽  
Author(s):  
Akira Sato ◽  
Toshiya Ishii ◽  
Kayo Adachi ◽  
Hideaki Takahashi ◽  
Fumiaki Sano ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Viral Clearance ◽  
Hepatitis C Virus Infection ◽  
Hepatitis C Virus Rna ◽  
Virus Genotype ◽  
Virus Rna ◽  
Chronic Hepatitis C Virus

Following interferon-based therapy for chronic hepatitis C, the negativity of hepatitis C virus RNA is essential to achieve viral clearance at the end of treatment. We report a case of clearance of chronic hepatitis C virus infection following early discontinuation (at 6 weeks) of peginterferon plus ribavirin therapy, without negativity for hepatitis C virus RNA during the treatment period. The patient was a 76-year-old Japanese male infected with hepatitis C virus genotype 1b and TT of IL28B rs8099917. Hepatitis C virus RNA remained positive at persistently low levels for more than 2 months after the cessation of therapy and became negative at 7 months after the discontinuation of therapy. Spontaneous clearance of hepatitis C virus RNA can occur following antiviral failure in patients with persistently low viral loads, and virological follow-up is therefore necessary in chronic hepatitis C virus infection, even after antiviral failure.

Sign in / Sign up

Export Citation Format

Share Document