scholarly journals The Role of Hypoxia in Normal Pregnancy and Pregnancy Complications

2018 ◽  
Vol 5 (2) ◽  
Author(s):  
Nadia Sheibak
Keyword(s):  
Pregnancy Complications ◽  
Normal Pregnancy

scholarly journals The physiologic and therapeutic role of Heparin in implantation and placentation

2014 ◽  
Author(s):  
Michela Quaranta ◽  
Offer Erez ◽  
Salvatore Andrea Mastrolia ◽  
Arie Koifman ◽  
Elad Leron ◽  
...  
Keyword(s):  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Preterm Labor ◽  
Normal Pregnancy ◽  
Fetal Demise ◽  
Therapeutic Role ◽  
Intrauterine Growth ◽  
Treatment And Prevention ◽  
Normal Gestation

Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications named the great obstetrical syndromes (preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture or membranes, preterm labor, and recurrent pregnancy loss). There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review we will summarize the properties and the physiological contribute of heparins to the success of implantation and placentation and normal pregnancy.

scholarly journals The physiologic and therapeutic role of Heparin in implantation and placentation

2014 ◽  
Author(s):  
Michela Quaranta ◽  
Offer Erez ◽  
Salvatore Andrea Mastrolia ◽  
Arie Koifman ◽  
Elad Leron ◽  
...  
Keyword(s):  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Preterm Labor ◽  
Normal Pregnancy ◽  
Fetal Demise ◽  
Therapeutic Role ◽  
Intrauterine Growth ◽  
Treatment And Prevention ◽  
Normal Gestation

Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications named the great obstetrical syndromes (preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture or membranes, preterm labor, and recurrent pregnancy loss). There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review we will summarize the properties and the physiological contribute of heparins to the success of implantation and placentation and normal pregnancy.

scholarly journals Hypoxia and Mitochondrial Dysfunction in Pregnancy Complications

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 405 ◽  
Author(s):  
Xiang-Qun Hu ◽  
Lubo Zhang
Keyword(s):  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Animal Studies ◽  
Major Effect ◽  
Causative Role ◽  
Therapeutic Approaches ◽  
Maternal Complications ◽  
Mitochondrial Ros ◽  
Subsequent Risk

Hypoxia is a common and severe stress to an organism’s homeostatic mechanisms, and hypoxia during gestation is associated with significantly increased incidence of maternal complications of preeclampsia, adversely impacting on the fetal development and subsequent risk for cardiovascular and metabolic disease. Human and animal studies have revealed a causative role of increased uterine vascular resistance and placental hypoxia in preeclampsia and fetal/intrauterine growth restriction (FGR/IUGR) associated with gestational hypoxia. Gestational hypoxia has a major effect on mitochondria of uteroplacental cells to overproduce reactive oxygen species (ROS), leading to oxidative stress. Excess mitochondrial ROS in turn cause uteroplacental dysfunction by damaging cellular macromolecules, which underlies the pathogenesis of preeclampsia and FGR. In this article, we review the current understanding of hypoxia-induced mitochondrial ROS and their role in placental dysfunction and the pathogenesis of pregnancy complications. In addition, therapeutic approaches selectively targeting mitochondrial ROS in the placental cells are discussed.

Deoxyribonuclease activity negative correlates with extracellular DNA in uncomplicated singleton pregnancies in the third trimester

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Barbora Vlková ◽  
Ľubica Janovičová ◽  
Petra Pšenková ◽  
Lívia Melníková ◽  
Barbora Balažovjechová ◽  
...  
Keyword(s):  
Pregnancy Complications ◽  
Extracellular Dna ◽  
Dnase Activity ◽  
Diffusion Method ◽  
Third Trimester ◽  
The Third ◽  
Healthy Women ◽  
Mitochondrial Origin ◽  
Singleton Pregnancies

Abstract Objectives It is not clear, which factors affect extracellular DNA (ecDNA) concentrations in healthy women with singleton uncomplicated pregnancies, although deoxyribonucleases (DNases) are hypothesized to be responsible for the cleavage of plasma ecDNA. The aim of this study was to analyze potential determinants of total ecDNA including plasma DNase activity. Methods Plasma samples were collected from 48 healthy women with singleton uncomplicated pregnancies in the third trimester (gestation week 37). DNA was isolated and quantified using fluorometry and real time PCR. DNase activity was assessed using the single radial enzyme-diffusion method. Results Neither ecDNA, nor DNase activity were affected by maternal age or BMI. DNase activity negatively correlated with total plasma ecDNA (r=−0.40, p=0.007). Similar associations were found for ecDNA of nuclear and mitochondrial origin, but not with fetal DNA quantified using Y-targeted PCR in male fetus-bearing pregnancies. Conclusions The role of plasma ecDNA of fetal and maternal origin is studied in the pathogenesis of pregnancy-complications. The results indicate that plasma DNase activity could negatively regulate ecDNA concentrations and should, thus, be analyzed in preeclampsia, preterm birth and other ecDNA-related pregnancy complications.

Toll-like Receptors at the Maternal-Fetal Interface in Normal Pregnancy and Pregnancy Complications

2014 ◽  
Vol 72 (2) ◽  
pp. 192-205 ◽  
Author(s):  
Kaori Koga ◽  
Gentaro Izumi ◽  
Gil Mor ◽  
Tomoyuki Fujii ◽  
Yutaka Osuga
Keyword(s):  
Pregnancy Complications ◽  
Normal Pregnancy ◽  
Toll Like Receptors ◽  
Maternal Fetal Interface

scholarly journals A STUDY TO ASSESS PREDICTIVE ROLE OF C-REACTIVE PROTEIN IN EARLY PREGNANCY AMONG WOMEN

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Neeti Mahla ◽  
Mukesh Choudhary
Keyword(s):  
Early Pregnancy ◽  
Quantitative Estimation ◽  
First Trimester ◽  
Normal Pregnancy ◽  
P Value ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Predictive Role ◽  
The Difference

Background: To Assess Predictive Role of C-Reactive Protein In Early Pregnancy among Women Methods: Hospital based comparative analysis was conducted on Women with early pregnancy upto 14 weeks with either abdominal pain or vaginal bleeding or suspected extrauterine pregnancy. C-reactive protein (CRP) quantitative estimation is done by turbi-diametric method. Collected samples were sent to a designated lab of our hospital. Results: The mean c-reactive protein level in cases 2.31 with min-max value ranging from 0.80-3.91mg/dl while in controls mean c-reactive protein value came to be 9.12 with min-max range from 3.21-24.16 mg/dl. The difference between the two groups is significant as p value is less than 0.001. Conclusion: Our results of significantly increased CRP levels in normal pregnancy and a clear association between CRP and normal pregnancy, support the clinical application of this diagnostic tool in early pregnancy, especially as a predictor of abnormal first trimester pregnancies. Keywords: CRP, Pregnancy, Women

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