scholarly journals Cloning and Expression of HP0242 Hypothetical Gene as a DNA Vaccine Candidate for Helicobacter pylori and Study of Its Immunoreactivity

2018 ◽  
Vol 13 (1) ◽  
Author(s):  
Zahra Bagheri ◽  
Abdolmajid Ghasemian ◽  
Seyyed Khalil Shokouhi Mostafavi ◽  
Abbas Doosti
Keyword(s):  
Helicobacter Pylori ◽  
Dna Vaccine ◽  
Vaccine Candidate ◽  
Cloning And Expression ◽  
Hypothetical Gene

Cloning and expression of nlpA gene as DNA vaccine candidate against Acinetobacter baumannii

2018 ◽  
Vol 45 (4) ◽  
pp. 395-401 ◽  
Author(s):  
Rassoul Hashemzehi ◽  
Abbas Doosti ◽  
Mohammad Kargar ◽  
Mojtaba Jaafarinia
Keyword(s):  
Acinetobacter Baumannii ◽  
Dna Vaccine ◽  
Vaccine Candidate ◽  
Cloning And Expression

Development and Evaluation of a DNA Vaccine Based on Helicobacter pylori urease B: Failure to Prevent Experimental Infection in the Mouse Model

Helicobacter ◽  
2006 ◽  
Vol 11 (6) ◽  
pp. 517-522 ◽  
Author(s):  
Livania Zavala-Spinetti ◽  
Mary B. Breslin ◽  
Hernán Correa ◽  
Rodolfo E. Bégué
Keyword(s):  
Helicobacter Pylori ◽  
Mouse Model ◽  
Dna Vaccine ◽  
Experimental Infection

scholarly journals Immunogenicity and Protective Efficiency in Mice of a Smallpox DNA Vaccine Candidate

2017 ◽  
Vol 08 (01) ◽  
Author(s):  
Na Young Kim ◽  
Dong Suk Chang ◽  
Gyeung Haeng Hur ◽  
Taek Yeol Lee ◽  
Jai Myung Yang ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Vaccine Candidate ◽  
Protective Efficiency

scholarly journals One or two dose regimen of the SARS-CoV-2 synthetic DNA vaccine INO-4800 protects against respiratory tract disease burden in nonhuman primate challenge model

2021 ◽  
Author(s):  
Karen Gooch ◽  
Trevor Smith ◽  
Francisco Salguero ◽  
Susan Fotheringham ◽  
Robert Watson ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Dose Regimen ◽  
Neutralizing Antibodies ◽  
Vaccine Candidate ◽  
Histopathological Examination ◽  
Macaque Model ◽  
Synthetic Dna ◽  
Intradermal Delivery ◽  
Viral Dose ◽  
Tract Disease

Abstract Safe and effective vaccines will provide essential medical countermeasures to tackle the COVID-19 pandemic. Here, we evaluate the safety, immunogenicity and efficacy of the intradermal delivery of INO-4800, a synthetic DNA vaccine candidate encoding the SARS-CoV-2 spike protein in the rhesus macaque model. Single and 2 dose vaccination regimens were evaluated. Vaccination induces both binding and neutralizing antibodies, along with IFN-γ-producing T cells against SARS-CoV-2. Upon administration of a high viral dose (5 x 106 pfu) via the intranasal and intratracheal routes we observe significantly reduced virus load in the lung and throat, in the vaccinated animals compared to controls. 2 doses of INO-4800 is associated with more robust vaccine-induced immune responses and improved viral protection. Importantly, histopathological examination of lung tissue provides no indication of vaccine-enhanced disease following SARS-CoV-2 challenge in INO-4800 immunized animals. This vaccine candidate is currently under clinical evaluation as a 2 dose regimen.

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