scholarly journals Effect of Betadine on Lymphocele Formation During Kidney Transplantation Surgery

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Farshad Namdari ◽  
Hossein Dialameh ◽  
Zoha Ali ◽  
Dorreh Farazandeh ◽  
Mahsa Kiani ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Kidney Transplant ◽  
Creatinine Level ◽  
Povidone Iodine ◽  
Control Group ◽  
Case Group ◽  
Random List ◽  
Transplantation Surgery ◽  
Group Control ◽  
Group Control Group

Background: Lymphocele formation post-renal transplantation surgery can cause various complications such as pelvic pain, frequent urination, hydronephrosis, deep vein thrombosis, etc. It is, therefore, necessary to prevent and treat lymphocele. Objectives: This study aimed to evaluate the effect of rinsing the surgical site with betadine (povidone-iodine 2%) on the prevention of lymphocele formation during kidney transplantation surgery. Methods: This case-control study was conducted at Tehran University of Medical Sciences in 2019. The study population consisted of 60 kidney transplant patients referred to Sina Hospital, located in Tehran, who were randomized into two groups of study and control by simple randomization using a computer-generated random list. The surgical site of one group (control group: 30 patients) was washed with povidone-iodine 2%, but this operation was not performed for the patients of the other group (control group: 30 patients). One month after the surgery, patients were monitored for lymphocele via ultrasound, and their sera’s creatinine level was measured to assess renal function. For all statistical interpretations, P < 0.05 value was accepted as being significant. Statistical analyses were performed with statistical software package SPSS version 23. Results: Results: The mean serum creatinine level of patients in the case group was 2.50 ± 1.78, and in the control group was 2.31 ± 1.89. Ultrasound performed one-month post-renal transplant showed the presence of lymphocele in 17 patients out of the total 30 in the study group, while the control group had only 12. Conclusions: It seems that the use of betadine during kidney transplant surgery does not prevent the formation of lymphocele after the surgery

scholarly journals Comparison of clinical outcome of induction immunosuppressive therapy with thymoglobulin and standard therapy in kidney transplantation; a randomized double-blind clinical trial

2019 ◽  
Vol 9 (1) ◽  
pp. e08-e08
Author(s):  
Heshmatollah Shahbazian ◽  
Ali Ghorbani ◽  
Fatemeh Hayati ◽  
Seyed Seifollah Beladi Mousavi ◽  
Leila Sabetnia ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Kidney Transplantation ◽  
Kidney Transplant ◽  
Induction Therapy ◽  
Allograft Rejection ◽  
Control Group ◽  
Case Group ◽  
Transplant Recipients ◽  
Acute Allograft Rejection ◽  
Kidney Transplant Recipients

Introduction: Thymoglobulin is a lymphocyte-depleting polyclonal antibody, administered for induction therapy at the time of kidney transplantation to reduce the risk of acute allograft rejection. The appropriate dosage and duration of therapy is controversial. The higher dosages are associated with infection and malignancy. Objectives: In this study efficacy and safety of lower dosage (in comparison with previous studies) of thymoglobulin in kidney transplant recipients was evaluated. Patients and Methods: In this clinical trial, 106 adult kidney transplant recipients, were randomized before transplantation in two groups (case and control). The case group (53 patients) were received induction therapy with thymoglobulin (1.5 mg/kg/d for 3 days) and the control group (53 patients) were received non-induction regiment. Delayed graft function (DGF), glomerular filtration rate (GFR), acute allograft rejection and thymoglobulin complications were evaluated during the first post-transplantation year. Results: Around 106 kidney transplant recipients were enrolled (71 or 66.98% deceased donor) to the study. No significant statistical differences were found in GFR at the time of discharge from hospital (P=0.399) and at 1 year (P=0.851) and acute allograft rejection (P= 0.304) between two groups. Graft survival (73.5% in case group versus 81.1% in control group, P=0.392) at month 12th was similar among groups. Additionally, no significant differences of acute allograft rejection in recipient from deceased or living donor between two groups were detected. There was a higher incidence of DGF in the control group (26.4%) than the thymoglobulin group (5.8%) and the difference was statistically significant (P= 0.004). Thrombocytopenia (17% versus 49.1%, P<0.001) and leukopenia (11.3% versus 50.9%, P<0.001) were also significantly higher in the case group. Conclusion: While the incidence of DGF was reduced in thymoglobulin group, the short-term acute allograft rejection rate was not reduced compared to the control group. However, our results require further consideration with larger samples

scholarly journals Clinical prediction and diagnosis of neurosyphilis in HIV-negative patients: a case-control study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yong Lu ◽  
Wujian Ke ◽  
Ligang Yang ◽  
Zhenyu Wang ◽  
Ping Lv ◽  
...  
Keyword(s):  
Roc Analysis ◽  
Treponema Pallidum ◽  
Neurological Symptoms ◽  
Control Group ◽  
Case Group ◽  
Alternative Test ◽  
And Gender ◽  
Group Control Group ◽  
No Gold Standard ◽  
Higher Sensitivity

Abstract Background Early diagnosis and treatment of neurosyphilis is of great significance for regression. There is no gold standard for the diagnosis of neurosyphilis. We did this study to explore the factors associated with the clinical diagnosis of neurosyphilis and assess their accuracy for the diagnosis of neurosyphilis. Methods We retrospectively reviewed 100 cases of syphilis patients who underwent lumbar puncture at a major dermatology hospital in Guangzhou, China between April 2013 and November 2016. Fifty patients who were clinically diagnosed with neurosyphilis were selected as case group. Control group consisted of 50 general syphilis patients who were matched with age and gender. The records of patients were reviewed to collect data of socio-demographic information, clinical symptom, and laboratory indicators. Multivariable logistic regression was used to explore diagnostic indictors, and ROC analysis was used to assess diagnostic accuracy. Results Neurological symptoms (odds ratio (OR) = 59.281, 95% CI:5.215–662.910, P = 0.001), cerebrospinal fluid (CSF) Treponema pallidum particle agglutination (TPPA) titer (OR = 1.004, 95% CI:1.002–1.006, P < 0.001), CSF protein (OR = 1.005, 95% CI:1.000–1.009, P = 0.041), and CSF white blood cell (WBC) (OR = 1.120, 95% CI:1.017–1.233, P = 0.021) were found to be statistically associated with neurosyphilis. In ROC analysis, CSF TPPA titer had a sensitivity of 90%, a specificity of 84%, and an area under curve (AUC) of 0.941. Conclusion CSF TPPA can potentially be considered as an alternative test for diagnosis of neurosyphilis. Combining with neurological symptoms, CSF protein, CSF WBC, the diagnosis would have a higher sensitivity.

scholarly journals A study on the use of henna plant (Lawsonia inermis Linn) for the treatment of fungal disease (Trichophypton verrucosum) in calves

2021 ◽  
Vol 71 (4) ◽  
pp. 2483
Author(s):  
H. HIZLI
Keyword(s):  
Clinical Examination ◽  
Treatment Process ◽  
Fungal Disease ◽  
Repeated Measurement ◽  
Control Group ◽  
Lawsonia Inermis ◽  
Group Control ◽  
Animal Material ◽  
Holstein Calves ◽  
Group Control Group

The aim of this study was to investigate the usability of henna plant (Lawsonia inermis Linn) in the treatment of dermatophytosis lesions (Trichophypton verrucosum) in cattle. The animal material of the trial consisted of 50 holstein calves between the ages of 4 and 6 months, who were found to have a dermatophytosis lesion on their face and neck in their clinical examination. The experiment was organized on a three-group repeated measurement trial plan. I. Group: Trichlorfon (Neguvon 75%, Bayer) ointment, II. Group: Henna applied, and III. Group: Control Group, no treatment, and 20 (10 females, 10 males), 20 (10 females, 10 males), and 10 (5 females, 5 males) totally 50 calves used, respectively. The research was continued for 14 days until the lesions were completely healed. I. and II. Groups were observed the best healing in the calves, respectively. In the III. Group without any treatment, there was no improvement and the lesions were enlarged. In addition, the effect of gender in the treatment process of dermatophytosis lesions was insignificant. As a result of this study, it is thought that henna plant can be used in the treatment of dermatophytosis.

scholarly journals The Teratogenic Mechanism of Echinochrome as a Hypoglycemic Agent on Wistar Rats

2019 ◽  
Vol 9 (1) ◽  
pp. 79-83
Author(s):  
Ayman S. Mohamed ◽  
Eman Y. Salah EL Din ◽  
Neveen A. Farag ◽  
Abdel Rahman A. Tawfik
Keyword(s):  
Wistar Rats ◽  
Low Dose ◽  
Body Weight Gain ◽  
Control Group ◽  
High Dose ◽  
Teratogenic Effects ◽  
Pregnant Rats ◽  
Hypoglycemic Agent ◽  
Group Control ◽  
Group Control Group

Background: Echinochrome (Ech) is the active ingredient in the Histochrome drug, which possesses strong antioxidant, hypolipidemic and hypoglycemic activity. Objective: The present work aimed to characterize the malformations induced by moderate and high dose of Ech during pregnancy. Methods: In this study, eighteen (18) female pregnant rats were assigned into 3 groups (6 rats/ group); control group, low dose Ech (0.1 mg/kg) and high dose Ech (1 mg/kg). Results: The high dose of Ech caused a significant decrease in the number of embryos, uteri weight, body weight gain, placenta weight, and embryo weight and length. Also, the high dose led to a significant increase in serum AST, ALT, ALP, urea and uric acid of mothers. Conclusion: Our findings revealed the first teratogenic effects of high dose Ech. The teratogenic mechanism of Ech works through induction of the hypoglycemic condition in pregnant rats.

scholarly journals Electroacupuncture at PC6 or ST36 Influences the Effect of Tacrine on the Motility of Esophagus

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Chi Wang ◽  
Xin Chen ◽  
Peng-Yan Xie
Keyword(s):  
The Other ◽  
Control Group ◽  
Group Model ◽  
Model Group ◽  
Gastric Distention ◽  
Group Control ◽  
Gastrointestinal Side Effects ◽  
Esophageal Sphincter ◽  
Group Control Group ◽  
Common Cavity

Aim.To investigate the mechanisms of gastrointestinal side effects of tacrine, and find treatment methods with electroacupuncture (EA).Methods. Twenty-five healthy cats were randomly divided into 5 groups: gastric-distention group (model group), tacrine group (cholinesterase inhibitor), tacrine + sham acupoint group (control group), tacrine + PC6 (neiguan) group, and tacrine + ST36 (zusanli) group, with 5 cats in each group. Saline 2 mL i.p. was given 30 min before gastric distention in model group. Tacrine 5.6 mg/kg i.p. was given 30 minutes before gastric distention in the other groups. Tacrine + sham acupoint group (control group), tacrine + PC6 group, and tacrine + ST36 group received EA at corresponding acupoints during gastric distention. The frequency of TLESRs and LESP were recorded by using a perfused sleeve assembly.Results. Compared with the model group, tacrine significantly increased the frequency of gastric distention-induced TLESR (P<0.05) but did not influence the rate of common cavity during TLESR. Tacrine significantly increased the LESP, which could not remain during gastric distention. EA at PC6 could decrease the frequency of TLESR and maintain the increase of LESP, but EA at ST36 did not have these effects.Conclusion. Tacrine can significantly increase the gastric distention-induced transient lower esophageal sphincter relaxations (TLESRs). Electroacupuncture (EA) at PC6 may reverse the above side effect.

scholarly journals Fat absorption after total gastrectomy in rats submitted to Roux-en-Y or Rosanov-like double-transit technique

2006 ◽  
Vol 21 (6) ◽  
pp. 380-384 ◽  
Author(s):  
Gustavo Sevá-Pereira ◽  
Luiz Roberto Lopes ◽  
Nelson Ary Brandalise ◽  
Nelson Adami Andreollo
Keyword(s):  
Total Gastrectomy ◽  
The Other ◽  
Control Group ◽  
Fat Absorption ◽  
Group Control ◽  
Fat Malabsorption ◽  
Group Control Group

PURPOSE: Steatorrhea is one of the most common complications in reconstruction after total gastrectomy. Many reconstruction techniques after total gastrectomy have been developed in order to avoid these undesirable effects, but each one of them has some inconvenience. In this experiment, a modified Rosanov technique that keeps duodenal transit, evaluation of fat absorption after gastrectomy was tested. METHODS: Three groups of rats with the same characteristics were used. Total gastrectomy was performed in two groups: one was operated on and transit was reestablished by the Roux-en-Y technique (group Y), while the other was submitted to the modified Rosanov technique (group R). Following surgery, a handmade hyper fatty diet (11% of fat) was offered. A third group (control - group C) was not operated but was submitted to the same conditions of the other groups, and used for reference steatocrit values. The animals underwent laparotomy 14 days after surgery and had their feces collected from cecum to determine their steatocrit by analysis of their values. RESULTS: Steatocrit values for groups R and C (mean 5.16% and 4.15% respectively) were similar (p > 0.1), while group Y had significantly higher values (mean = 28.18%, p = 0.0001 - p < 0,05). This was attributed to the fact that group R animals had their duodenal transit patent, decreasing the complications expected in the Roux-en-Y reconstruction. CONCLUSIONS: Steatorrhea in the modified Rosanov technique was similar to the control group, while Roux-en-Y reconstruction presented higher steatorrhea and fat malabsorption.

scholarly journals Risk Factor Analysis of Dengue Shock Syndrome Occuring to Children in RSD dr. Soebandi Jember Regency

2017 ◽  
Vol 3 (1) ◽  
pp. 56
Author(s):  
Oessi Salsabila ◽  
Muhammad Ali Shodikin ◽  
Dwita Aryadina Rachmawati
Keyword(s):  
Nutritional Status ◽  
Dengue Shock Syndrome ◽  
Emergency Situation ◽  
Medical Emergency ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Retrospective Case ◽  
Chi Square ◽  
Group Control Group

Dengue Shock Syndrome is a medical emergency situation caused by shocking DHF. Some factors that can influence the DSS. The purpose of this research know some risk factors that might cause DSS. Those are age, nutritional status, gender, and amount of platelet and hematocrit. This research was retrospective case control doing in dr. Soebandi Hospital Jember. The sample were divided into 2 groups. Those were DSS (case group) and non-DSS group (control group). Data analysis was done by Chi-Square test using SPSS 21 version. These were 136 patients which were divided into 94 patients of control group and 42 patients of case group. In this research, there were p-value for ages, nutritional status, gender, amount of platelet and hematocrit on each 0,450; 0,490; 0,198; 0,001; 0,007 respectively. In this search, it could be concluded that age, nutritional status, and gender were not significantly related to DSS case although amount of platelet and hematocrit were significantly related to DSS case.Keywords:dengue shock syndrome, age, nutritional status, gender, hematocrit, platelet.

scholarly journals SINGLE BULB GARLIC (Allium sativum) EXTRACT IMPROVE SPERM QUALITY IN HYPERLIPIDEMIA MALE MICE MODEL

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Nosi Qadariah ◽  
Sri Rahayu Lestari ◽  
Fatchur Rohman
Keyword(s):  
High Fat Diet ◽  
Sperm Quality ◽  
Sperm Count ◽  
Garlic Extract ◽  
Control Group ◽  
Male Mice ◽  
Mice Model ◽  
High Fat ◽  
Group Control ◽  
Group Control Group

The aim of this research was to find out the influence of single bulb garlic on sperm quality improvement in hyperlipidemia model of male mice. Male mice (Balb-C, 12 weeks, bw 21±5 g) were given high fat diet for 45 days until their body weight achieved 45±5 g. The mice were then divided into six groups. The mice in the first group (control group (N)) was fed with 7 g higrow pokphan 551 per day. The mice in the second group (control negative group) was fed with 7 g high fat diet (HFD), while the mice in the third group (control positive group) were treated with statin at  dose of 0.91 mg. The mice in groups 4, 5, and 6 were treated with single bulb garlic extract at dose of 125 mg/kg bw, 250 mg/kg bw, and 500 mg/kg bw, respectively. On the 31st day, the male were dissected and cauda epididymis was taken and chopped in a sterile phosphat buffer saline (PBS) and observation conducted on sperm quality consisted of sperm count, sperm motility and sperm normality. The results indicated a significant increase in sperm count, motility and normality in mice treated with single bulb garlic extract at dose of 250 mg/kg bw.

scholarly journals Evaluation of Nitric Oxide Concentrations in Preeclampsia and Normal Pregnancy

2020 ◽  
Vol 32 (2) ◽  
pp. 60-66
Author(s):  
Salma Akter ◽  
Firoza Begum ◽  
Sharmin Abbasi
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
Normal Pregnancy ◽  
Control Group ◽  
Case Group ◽  
Nitrite Level ◽  
The Mean

During pregnancy Nitric oxide is one of the most important relaxing factors for myometrium and also in the control of blood flow in uterus and placenta. Nitric oxide is generated by endothelial type II nitric oxide synthase (NOS) and acts as a vasodilator. Objective:To investigate the level of nitric oxide (NO) production in pregnancies complicated by preeclampsia and in normal pregnancy. Materials and Methods: A case control study was undertaken in Department of Gynaecology and Obstetrics of Bangabandhu Sheikh Mujib Medical University (BSMMU), from january to july 2014. The study population was pregnant women having preeclampsia and normal pregnancy who attended the OPD Department of Obstetrics and Gynecology in BSMMU between 29 to 40 weeks of gestation. As because of transient and volatile nature of nitric oxide, it was unsuitable to measure the nitric oxide level by conventional method. However, two stable break down product, nitrate (NO3 -) and nitrate (NO2 -) could be easily detected by sprectophototric means. Nitrate (NO2 -) was first converted to Nitrite (NO3 -) by reduction process using cadmium. Then concentration was measured by using Griess reagent in UV sprectophototric machine. This procedure was done in the Biochemistry Department, Dhaka University. Results: The mean nitrite level was found 18.37}3.64 mol/L in case group and 25.57}2.11mol/ L in control group, which was significantly (p<0.05) higher in control group. The mean serum creatinine level was found 1.19}0.28 mg/dl in case group and 0.65}0.1 mg/dl in control group. The mean serum creatinine level was significantly (p<0.05) higher in case groups. Nitrite level had no correlation with onset of hypertension (r=-0.006; p=0.966), onset of proteinuria (r=0.071; p=0.623), systolic blood pressure (r=0.012; p=0.933), diastolic blood pressure (r=-0.159; p=0.269) and urine protein (r=0.047, p=0.748). Conclusion: As pregnancy progressed there was a decrease in plasma nitric oxide levels in preeclampsia. Urine uric acid to creatinine ratio increased with the decrease in nitric oxide levels and can be used as a marker for preeclampsia. Bangladesh J Obstet Gynaecol, 2017; Vol. 32(2) : 60-66

scholarly journals Hubungan antara Berat Badan Berlebih dengan Terjadinya Sindrom Syok Dengue pada Anak di RSD dr. Soebandi, Jember

2020 ◽  
Vol 7 (1) ◽  
pp. 35
Author(s):  
Hana Nabilah ◽  
M. Ali Shadikin ◽  
Rony Prasetyo
Keyword(s):  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Retrospective Case ◽  
Chi Square ◽  
Chi Square Test ◽  
Group Control Group ◽  
Chi Square Analysis

Dengue Shock Syndrome (DSS) is shock syndrome that happened in dengue hemorrhagic fever patients. There are risk factors that cause DSS. One of them is overweight in children. This study aimed to determine the relationship between overweight and the occurence of DSS. This retrospective case control study conducted at the dr. Soebandi Hospital Jember. Sampels were divided into DSS group (case group) and non-DSS group (control group). To analyze the data, Chi-Square test was performed using SPSS version 21. Aa many as 191 patients were included in this study which consisted of 132 patients as the control group and 59 patients as the case group. Chi-square analysis showed the p-value was 0,649. In conclusion, overweight was not significantly associated as a risk factor of DSS in children at the dr. Soebandi hospital.

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