scholarly journals Comparison of Intravenous Ibuprofen with Intravenous Ketorolac in Renal Colic Pain Management; A Clinical Trial

2019 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Mohammad Mehdi Forouzanfar ◽  
Khaghan Mohammadi ◽  
Behrouz Hashemi ◽  
Saeed Safari
Keyword(s):  
Clinical Trial ◽  
Pain Management ◽  
Renal Colic ◽  
Intravenous Ibuprofen ◽  
Intravenous Ketorolac

scholarly journals Comparing the efficacy of intravenous ketorolac versus intravenous ibuprofen in relieving renal colic pain; a randomized clinical trial

2018 ◽  
Vol 7 (2) ◽  
pp. 122-125
Author(s):  
Seyed Hossein Shaker ◽  
Seyed Ahmad Borghei
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Renal Colic ◽  
Epigastric Pain ◽  
Renal Stones ◽  
Pain Severity ◽  
Gastrointestinal Complications ◽  
Significant Difference ◽  
Intravenous Ibuprofen ◽  
Intravenous Ketorolac

Introduction: Various therapies have been used to relieve or improve the urinary colic pain, but many of these treatments have been limited due to side effects associated with the drugs. In this regard, opioid drugs and nonsteroidal anti-inflammatory drugs (NSAIDs) have a higher priority than other treatments. Objectives: The aim of the present study was to compare the level of pain relief from renal stones after the administration of two types of NSAIDs, including intravenous ibuprofen versus intravenous ketorolac. Patients and Methods: In this clinical trial (identifier: IRCT20180108038276N1), 70 patients with renal colic pain were randomly treated with intravenous ketorolac (30 mg, n = 35) or with intravenous ibuprofen (800 mg, n = 35). The patient’s pain severity was assessed by the visual analogue scaling (VAS) method before and 20 and also 60 minutes after interventions. Results: Although pain severity considerably reduced within 60 minutes of prescribing ibuprofen and ketorolac, the trend of the change in pin score was not different between the two groups (P = 0.734). We found no significant difference in appearance of some side effects including nausea and vomiting, requiring use of ondansetron, need to prescribe additional analgesics. However epigastric pain and need to administrating H2 blockers were not revealed in the group receiving ketorolac, but these complications were found in 25.7% of the patients received ibuprofen indicating a significant difference (P = 0.002). Conclusion: A single dose administration of both intravenous ketorolac and ibuprofen is associated with significant improvement in renal colic pain within one hour after administration. However, due to the lower incidence of gastrointestinal complications in the administration of ketorolac compared to ibuprofen, the use of ketorolac in treatment and relief of renal colic pains is preferable.

scholarly journals Intranasal Ketamine Versus Intravenous Ketorolac for Pain Control in the Renal Colic: A Randomized Clinical Trial Study

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Ali Khavanin ◽  
Meisam Moezzi ◽  
Hassan Motamed ◽  
Samaneh Parozan ◽  
Abdolreza Hosseini
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Pain Control ◽  
Renal Colic ◽  
Intervention Group ◽  
Vital Signs ◽  
Control Group ◽  
Post Dose ◽  
Patients Satisfaction ◽  
Intravenous Ketorolac

Background: Renal colic is one of the most common complaints among patients referring to the emergency department (ED). Non-steroidal anti-inflammatory drugs (NSAIDs) and opioids are gold standards to relieve pain. Objectives: The aim of this study was to evaluate the effects of intranasal Ketamine on pain control versus Ketorolac. Methods: In this randomized clinical trial (RCT), the patients were randomly assigned into two groups. While Ketorolac 30 mg was given intravenously to all patients in the control group, the patients in intervention group received 1 mg/kg drops of Ketamine intranasally. Pain severity, vital signs, and adverse events (AEs) were recorded after 60 min post-dose. Results: A total of 100 patients were enrolled in this study. The mean visual analog scale (VAS) score after the first 5 min was lower in the intranasal Ketamine group compared to control (5 ± 2.26 vs. 8.62 ± 0.49, respectively; P < 0.001), which remained significant at the end of 60th min (P < 0.001). Moreover, additional analgesics administration was higher in intravenous Ketorolac than intranasal Ketamine (22 vs 0%), which was significantly different (P = 0.001). Patients' satisfaction was higher in the intranasal Ketamine group compared to control (3.56 ± 0.35 vs. 1.82 ± 0.98, respectively; P < 0.001). Conclusions: Intranasal Ketamine was beneficial in controlling renal colic-induced pain, which could be prescribed as a treatment instead of normal treatment. It can rapidly improve pain relief in the short term, has lower AEs, and increases the patients' satisfaction.

scholarly journals Intravenous acetaminophen versus morphine sulfate in pain management of acute renal colic: a randomized clinical trial

2017 ◽  
Vol 4 (1) ◽  
pp. 39-43
Author(s):  
Seyyed Hosein Montazer ◽  
Behzad Feizzadeh ◽  
Farzad Bozorgi ◽  
Seyed Mohammad Hosseininejad ◽  
Ayyoub Barzegarnezhad ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Pain Management ◽  
Randomized Clinical Trial ◽  
Renal Colic ◽  
Morphine Sulfate ◽  
Intravenous Acetaminophen ◽  
Acute Renal Colic

Comparing Intradermal Sterile Water with Intravenous Morphine in Reducing Pain in Patients with Renal Colic: A Double-Blind Randomized Clinical Trial

2020 ◽  
Vol 15 (1) ◽  
pp. 76-82
Author(s):  
Javad Mozafari ◽  
Mohammadreza Maleki Verki ◽  
Fatemeh Tirandaz ◽  
Reza Mahjouri
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Renal Colic ◽  
Therapeutic Effects ◽  
Sterile Water ◽  
Morphine Group ◽  
Double Blind ◽  
Water Group ◽  
Intravenous Morphine ◽  
Painful Area

Objective: The present study was conducted to investigate the effect of intradermal administration of sterile water compared to intravenous morphine on patients with renal colic. Methods: This double-blind, randomized clinical trial study was conducted in 2017 to compare the therapeutic effects of intradermal sterile water with those of intravenous morphine on patients with renal colic presenting to the emergency departments (ED) of Imam Khomeini and Golestan Hospitals in Ahvaz, Iran. The first group received 0.5 ml of intradermal sterile water, and the second group 0.1mg/kg of intravenous morphine plus 0.5 ml of intradermal sterile water in the most painful area or the center of the painful area in the flank. The pain severity was measured using a visual analogue scale (VAS), and the medication side-effects were recorded at the beginning of the study and minutes 15, 30,45 and 60. Result: A total of 94 patients were studied in two groups. The mean severity of pain was 2.97 ± 1.51 in the sterile water group and 2.34 ± 1.89 in the morphine group at minute 30 (P=0.042), 2.58 ± 1.43 in the sterile water group and 1 ± 1.23 in the morphine group at minute 45 (p<0.001), and 1.89 ± 1.7 in the sterile water group and 0.52 ± 0.79 in the morphine group at minute 60 (p<0.001). Conclusion: Morphine reduces pain faster and more effectively than intradermal sterile water; nevertheless, treatment with intradermal sterile water can be used as an appropriate surrogate or adjunct therapy for pain control, particularly in special patients or in case of medication scarcity.

Single-dose intramuscular ketorolac versus diclofenac for pain management in renal colic

1996 ◽  
Vol 14 (4) ◽  
pp. 385-387 ◽  
Author(s):  
A Stein ◽  
D.Ben Dov ◽  
B Finkel ◽  
Y Mecz ◽  
R Kitzes ◽  
...  
Keyword(s):  
Single Dose ◽  
Pain Management ◽  
Renal Colic ◽  
Intramuscular Ketorolac
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