scholarly journals A case of small cell carcinoma of the lung differentiated toward large cell carcinoma and adenocarcinoma during treatment.

1991 ◽  
Vol 30 (3) ◽  
pp. 507-511
Author(s):  
Hitoshi HIRATA ◽  
Yutaka MIZUSHIMA ◽  
Saburo YANO ◽  
Mikio KITASAWA ◽  
Ken FUKUMURA ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Small Cell

Neuro-endocrine tumours of the head and neck

1990 ◽  
Vol 104 (6) ◽  
pp. 504-507 ◽  
Author(s):  
A. C. Soussi ◽  
A. Benghiat ◽  
C. S. Holgate ◽  
B. Majumdar
Keyword(s):  
Cell Carcinoma ◽  
Head And Neck ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Differential Response ◽  
Small Cell ◽  
Endocrine Tumours ◽  
Carcinoma Of The Larynx

AbstractWe report two types of neuroendocrine carcinoma of the head and neck, small cell carcinoma of the ethmoid and large cell carcinoma of the larynx, demonstrating a differential response to radiotherapy.

The role of surgery in the management of selected patients with small-cell carcinoma of the lung.

1987 ◽  
Vol 5 (5) ◽  
pp. 697-702 ◽  
Author(s):  
R R Baker ◽  
D S Ettinger ◽  
J D Ruckdeschel ◽  
J C Eggleston ◽  
M F McKneally ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Primary Tumor ◽  
Residual Disease ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Operative Specimen

This study was designed to evaluate the efficacy of surgical resection of the primary tumor and lymph nodes in patients with localized small-cell carcinoma who had responded to induction chemotherapy. The study was performed in 37 patients who received two cycles of chemotherapy consisting of cyclophosphamide, doxorubicin, and etoposide. Those patients who achieved a complete or partial (greater than 50%) response were evaluated for thoracotomy and the primary tumor and regional lymph nodes excised when feasible. Postoperatively, the patients received prophylactic cranial irradiation and were maintained on the same chemotherapy for an average of 11 months. Twelve patients were resected and found to have residual small-cell carcinoma in the operative specimen (ten) or no residual disease (two). Seven of these patients (58%) are alive without evidence of disease (median follow-up, 24 months). Seven other patients who were resected proved to have either residual foci or small-cell carcinoma mixed with adenocarcinoma or large-cell carcinoma (four) or only focal areas of adenocarcinoma, large-cell carcinoma, or squamous-cell carcinoma with no evidence of residual small-cell carcinoma. Five of these patients (71%) are alive without evidence of disease (median follow-up, 36 months). Two of the 16 patients who were not resected but treated with chemotherapy and radiation are alive at 15 and 31 months without evidence of disease, the other 14 are dead of disease.

Large-cell variant of small cell carcinoma of the ovary with hypercalcaemia

2000 ◽  
Vol 264 (3) ◽  
pp. 157-158 ◽  
Author(s):  
G. Di Vagno ◽  
G. A. Melilli ◽  
G. Cormio ◽  
D. Piscitelli ◽  
A. Ciampolillo ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Cell Variant ◽  
Carcinoma Of The Ovary

scholarly journals The cytomorphologic spectrum of small-cell carcinoma and large-cell neuroendocrine carcinoma in body cavity effusions: A study of 68 cases

CytoJournal ◽  
2011 ◽  
Vol 8 ◽  
pp. 18 ◽  
Author(s):  
Walid E. Khalbuss ◽  
Huaitao Yang ◽  
Qian Lian ◽  
Abdelmonem Elhosseiny ◽  
Liron Pantanowitz ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Single Cell ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Body Cavity ◽  
Small Cell ◽  
Cell Clusters ◽  
Cell Pattern ◽  
Ancillary Studies

Background: Small-cell carcinoma (SCC) and large-cell neuroendocrine carcinoma (LCNEC) are uncommon in serous body cavity effusions. The purpose of this study is to examine the cytomorphological spectrum of SCC and LCNEC in body cavity serous fluids. Materials and Methods: We have 68 cases from 53 patients who had metastatic SCC or LCNEC diagnoses. All cytology slides and the available clinical data, histological follow-up, and ancillary studies were reviewed. Results: A total of 68 cases (60 pleural, 5 peritoneal, and 3 pericardial effusions) from 53 patients with an average age of 73 years (age range 43-92 years) were reported as diagnostic or suspicious of SCC (52 cases) or LCNEC (16 cases). The primary site was lung in 56 cases, pancreas in 6 cases, and 2 cases each from cervix, colon, and the head and neck region. Of the 68 cases, 48 cases had no history of malignancy of the same type. Ancillary studies were used in 46 cases (68%) including flow cytometric studies in 5 cases. There were three predominant cytomorphological patterns observed including small-cell clusters with prominent nuclear molding (33 cases, 49%), large-cell clusters mimicking non-small-cell carcinoma (18 cases, 26%), and single-cell pattern mimicking lymphoma (17 cases, 25%). Significant apoptosis was seen in 22 cases (33%) and marked tumor cell cannibalism was seen in 11 cases (16%). Nucleoli were prominent in 16 cases (24%). The most frequent neuroendocrine markers performed were synaptophysin and chromogranin. Conclusions: The most common cytomorphologic patterns seen in body cavity effusions of SCC and LCNEC were small-cell clusters with nuclear molding. However, in 51% of the cases either a predominant single-cell pattern mimicking lymphoma or large-cell clusters mimicking non-small carcinoma were noted. In our experience, effusions were the first manifestation of disease in the majority of patients diagnosed with neuroendocrine carcinoma. Therefore, familiarity with the cytomorphological spectrum of neuroendocrine carcinomas in fluid cytology may help in rapidly establishing an accurate diagnosis and in directing appropriate management.

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