Large-cell variant of small cell carcinoma of the ovary with hypercalcaemia

2000 ◽  
Vol 264 (3) ◽  
pp. 157-158 ◽  
Author(s):  
G. Di Vagno ◽  
G. A. Melilli ◽  
G. Cormio ◽  
D. Piscitelli ◽  
A. Ciampolillo ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Cell Variant ◽  
Carcinoma Of The Ovary

Small cell carcinoma of the ovary: A case report of large cell variant

1997 ◽  
Vol 47 (4) ◽  
pp. 250-255 ◽  
Author(s):  
Masaharu Fukunaga ◽  
Yasuhiko Endo ◽  
Kouichi Nomura ◽  
Shinchiro Ushigome
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Cell Variant ◽  
Carcinoma Of The Ovary

Cytological Features of the Large Cell Variant of Small Cell Ovarian Carcinoma in Young Patients with Hypercalcemia: Histological Findings and Review of the Literature

2017 ◽  
Vol 61 (6) ◽  
pp. 462-468 ◽  
Author(s):  
Helen J. Trichia ◽  
Paraskevi Tziakou ◽  
Dimitrios C. Papatheodorou ◽  
Joanna Lekka
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Frozen Section ◽  
Young Patients ◽  
Large Cell ◽  
Small Cell ◽  
Eosinophilic Cytoplasm ◽  
Cytological Features ◽  
Cell Variant ◽  
Carcinoma Of The Ovary

Objective: To present the cytological features of a very rare and lethal ovarian neoplasm occurring in the young. Study Design: We reviewed the cytological findings as they presented in touch imprints obtained from an ovarian mass sent to our department for frozen section investigation. Results: Smears were highly cellular. The cells were of intermediate size with a moderate amount of microvacuolated, pale, or eosinophilic cytoplasm with indistinct cell borders. The nuclei were of round or oval shape with mild to moderate atypia and indistinct nucleoli. Conclusions: The diagnosis of small cell carcinoma of the ovary can be challenging even histologically. Cytology can be an invaluable adjunct to hematoxylin-eosin sections both pre- or intraoperatively. Although it is a very rare occurrence and cytological results are almost absent in the literature, our case can make cytopathologists more acquainted with the cytological features of this rare tumor entity especially in association with a characteristic clinical profile. Furthermore, the cytological features of small cell carcinoma of the ovary, large cell variant, have only rarely been described in the literature.

Large cell variant of small cell carcinoma, hypercalcemic type, of primary peritoneal origin

2005 ◽  
Vol 96 (1) ◽  
pp. 249-253 ◽  
Author(s):  
Dorota A. Popiolek ◽  
Asok R. Kumar ◽  
Khush Mittal
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Cell Variant

Large Cell Variant Ovarian Small Cell Carcinoma: Case Report

2008 ◽  
Vol 32 (5) ◽  
pp. 206-210 ◽  
Author(s):  
Giuseppe Donato ◽  
Francesco Conforti ◽  
Valeria Zuccalà ◽  
Carmen Cosco ◽  
Costanza Laratta ◽  
...  
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Cell Variant

Small Cell Carcinoma of the Ovary, Hypercalcemic Type, in a 12-Month-Old Girl

2021 ◽  
pp. 109352662110212
Author(s):  
Doaa Atwi ◽  
Michael R Quinton ◽  
Ryan M Kiser ◽  
Hanumantha R Pokala ◽  
Laura M Rooms ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Abdominal Mass ◽  
Large Cell ◽  
Small Cell ◽  
Molecular Signature ◽  
Mild Anemia ◽  
Pathogenic Variants ◽  
Patient Reported ◽  
Carcinoma Of The Ovary

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a highly aggressive malignant tumor affecting predominantly young adults and adolescents with an average age of 23.9 at time of diagnosis. Up to two thirds of patients have paraneoplastic hypercalcemia. The molecular signature of these tumors is SMARCA4 mutations, with somatic and germline pathogenic variants previously described. We report a case of a previously healthy one-year-old girl who was noticed to have mild anemia and an abdominal mass during a well-child visit. Further laboratory testing revealed hypercalcemia. A computerized tomography scan showed a left-sided ovarian mass (9.3 x 7.3 x 7 cm). The resection specimen showed a large ovarian tumor with solid tan-yellow cut surfaces and small foci of necrosis. Microscopically, the tumor was composed of sheets of small, hyperchromatic epithelioid cells with focal rhabdoid large cell morphology. The tumor cells were strongly and diffusely positive for WT1 (N-terminal antibodies) with focal EMA and Pan-keratin positivity. Absent SMARCA4 (BRG1) protein expression by immunohistochemistry ultimately established the diagnosis of small cell carcinoma of the ovary, hypercalcemic type. To our knowledge, this is the youngest patient reported in the literature.

Small cell carcinoma of the ovary: A rapidly lethal tumor occurring in the young

1985 ◽  
Vol 22 (2) ◽  
pp. 233-239 ◽  
Author(s):  
Bruce Patsner ◽  
M.Steven Piver ◽  
Shashikant B. Lele ◽  
Yoshiaka Tsukada ◽  
Kenneth Bielat ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Carcinoma Of The Ovary

Small cell carcinoma of the ovary: clinical and biological study

2008 ◽  
Vol 13 (2) ◽  
pp. 161-165 ◽  
Author(s):  
Seiji Isonishi ◽  
Hiroshi Nishii ◽  
Motoaki Saitou ◽  
Makoto Yasuda ◽  
Takako Kiyokawa ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Biological Study ◽  
Carcinoma Of The Ovary

scholarly journals A case of small cell carcinoma of the lung differentiated toward large cell carcinoma and adenocarcinoma during treatment.

1991 ◽  
Vol 30 (3) ◽  
pp. 507-511
Author(s):  
Hitoshi HIRATA ◽  
Yutaka MIZUSHIMA ◽  
Saburo YANO ◽  
Mikio KITASAWA ◽  
Ken FUKUMURA ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Small Cell

scholarly journals The cytomorphologic spectrum of small-cell carcinoma and large-cell neuroendocrine carcinoma in body cavity effusions: A study of 68 cases

CytoJournal ◽  
2011 ◽  
Vol 8 ◽  
pp. 18 ◽  
Author(s):  
Walid E. Khalbuss ◽  
Huaitao Yang ◽  
Qian Lian ◽  
Abdelmonem Elhosseiny ◽  
Liron Pantanowitz ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Single Cell ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Body Cavity ◽  
Small Cell ◽  
Cell Clusters ◽  
Cell Pattern ◽  
Ancillary Studies

Background: Small-cell carcinoma (SCC) and large-cell neuroendocrine carcinoma (LCNEC) are uncommon in serous body cavity effusions. The purpose of this study is to examine the cytomorphological spectrum of SCC and LCNEC in body cavity serous fluids. Materials and Methods: We have 68 cases from 53 patients who had metastatic SCC or LCNEC diagnoses. All cytology slides and the available clinical data, histological follow-up, and ancillary studies were reviewed. Results: A total of 68 cases (60 pleural, 5 peritoneal, and 3 pericardial effusions) from 53 patients with an average age of 73 years (age range 43-92 years) were reported as diagnostic or suspicious of SCC (52 cases) or LCNEC (16 cases). The primary site was lung in 56 cases, pancreas in 6 cases, and 2 cases each from cervix, colon, and the head and neck region. Of the 68 cases, 48 cases had no history of malignancy of the same type. Ancillary studies were used in 46 cases (68%) including flow cytometric studies in 5 cases. There were three predominant cytomorphological patterns observed including small-cell clusters with prominent nuclear molding (33 cases, 49%), large-cell clusters mimicking non-small-cell carcinoma (18 cases, 26%), and single-cell pattern mimicking lymphoma (17 cases, 25%). Significant apoptosis was seen in 22 cases (33%) and marked tumor cell cannibalism was seen in 11 cases (16%). Nucleoli were prominent in 16 cases (24%). The most frequent neuroendocrine markers performed were synaptophysin and chromogranin. Conclusions: The most common cytomorphologic patterns seen in body cavity effusions of SCC and LCNEC were small-cell clusters with nuclear molding. However, in 51% of the cases either a predominant single-cell pattern mimicking lymphoma or large-cell clusters mimicking non-small carcinoma were noted. In our experience, effusions were the first manifestation of disease in the majority of patients diagnosed with neuroendocrine carcinoma. Therefore, familiarity with the cytomorphological spectrum of neuroendocrine carcinomas in fluid cytology may help in rapidly establishing an accurate diagnosis and in directing appropriate management.

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