scholarly journals Glaucoma and Dry Eye

2021 ◽  
Author(s):  
Mauricio Aguirre Baez ◽  
Rodrigo Castillo Iturria
Keyword(s):  
Chronic Inflammation ◽  
Dry Eye ◽  
Topical Treatment ◽  
Ocular Surface ◽  
Rational Treatment ◽  
Eye Symptoms ◽  
Glaucoma Treatment ◽  
Meibomian Glands ◽  
Preservative Free

Glaucoma treatment is closely related to the appearance or worsening of dry eye symptoms. The current topical treatment produces chronic inflammation that affects globet cells, meibomian glands and cornea, which translates into a decrease in the quantity and quality of the tear. It is characterized by increased osmolarity, which perpetuates damage to the ocular surface. Preservatives currently play a fundamental role in damage the ocular surface. There are numerous studies that have shown their toxic effects on the eye. Currently there are numerous preservative-free formulations and new therapies that allow us to improve the condition of the ocular surface in patients with glaucoma. A rational treatment is proposed using the different approaches available in the literature.

scholarly journals The Functional State of Meibomian Glands and Tear Production in Pregnant Women

2018 ◽  
Vol 15 (2) ◽  
pp. 151-159
Author(s):  
V. N. Trubilin ◽  
E. G. Poluninа ◽  
D. V. Andzhelova ◽  
Yu. V. Evstigneeva ◽  
K. V. Chinenova
Keyword(s):  
Quality Of Life ◽  
Pregnant Women ◽  
Functional State ◽  
Dry Eye ◽  
Ocular Surface ◽  
Contact Lenses ◽  
Dry Eye Syndrome ◽  
Symptom Complex ◽  
Meibomian Glands

Pregnant women are objects of special medical attention due to the fact that the new life — the life of her child — depends on the health  and quality of life of the future mother. Pregnancy is a physiological  load. It makes temporary changes in the functional state of all  organs and systems, including the organ of vision. This study was  aimed at identifying risk factors for the occurrence of disturbances in the tear-producing system — dysfunction of the Meibomian glands  and/or dry eye syndrome (SSH), as well as to develop recommendations for compensating of disturbance. The  study showed that physiological pregnancy does not affect to the  condition of the ocular surface in case of absence of dry eye  syndrome manifestations and Meibomian gland dysfunction before  pregnancy. However, there is a predisposition for the development of the symptom complex of dry eye syndrome — a reliable decrease  Schirmer test indicators of the test of in the group of pregnant  women, it requires preventive control, — reduction in the mode of  wearing contact lenses, which are a risk factor for the development  of dry eye syndrome. It was determined that in vitro fertilization  (IVF) affects to the condition of the ocular surface, namely, on the  occurrence of dysfunction of Meibomian glands and dry eye  syndrome, and is accompanied by corresponding complaints. There  is a direct correlation between the duration of gestation, age  indicators, the severity of complaints and their relationship to  pregnancy. A direct was established, with a noticeable tightness of  communication, between taking thyrotrophic drugs and complaints  on dryness and discomfort. Therefore, special attention should be  given to pregnant patients taking thyrotrophic medications and using contact lenses, since both of these factors provoke the development  of the dry eye symptom complex. Patients with IVF pregnancy and  accompanied by taking thyrotrophic drugs are recommended to limit  the mode of wearing contact lenses, in case of complaints on  dryness, discomfort, it is necessary to conduct therapeutic and  prophylactic effects in the form of non-conserved tear-replacement  therapy and eyelid hygiene. Timely diagnosis and subsequent  prevention of Meibomian glands and dry eye syndrome in pregnant  women will improve the quality of life of this patients group and  prevent the development of complications related to this condition.

scholarly journals How Ocular Surface Disease Impacts the Glaucoma Treatment Outcome

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Snježana Kaštelan ◽  
Martina Tomić ◽  
Kata Metež Soldo ◽  
Jasminka Salopek-Rabatić
Keyword(s):  
Ocular Surface ◽  
Microbial Contamination ◽  
Standard Form ◽  
Ocular Surface Disease ◽  
Treatment Goals ◽  
Corneal Epithelial ◽  
Glaucoma Treatment ◽  
Preservative Free

The treatment goals for glaucoma are lowering the intraocular pressure and preservation of vision. Topical hypotensive drops are the standard form of therapy which is often associated with some symptoms of toxicity, ocular inflammation, allergy, or ocular surface disease (OSD). OSD is a common comorbidity in glaucoma patients, and its prevalence with glaucoma increases with age. Use of topical treatment could additionally increase symptoms of OSD mostly due to preservatives added to multidose medication bottles used to reduce the risk of microbial contamination. This toxicity has been particularly associated with BAK, the most commonly used preservative which damages conjunctival and corneal epithelial cells and significantly aggravates OSD symptoms. OSD adversely affects patients’ quality of life causing discomfort and problems with vision which in turn may result in noncompliance, lack of adherence, and eventually visual impairment. In the management of glaucoma patients OSD symptoms should not be overlooked. If they are present, topical glaucoma treatment should be adapted by decreasing the amount of drops instilled daily, using BAK-free or preservative-free medication and lubricants if necessary. Awareness of the presence and importance of OSD will in turn improve patients' adherence and compliance and thus ultimately the preservation of long-term vision.

Effect of changing from preserved prostaglandins to preservative-free tafluprost in patients with glaucoma on tear film thickness

2018 ◽  
Vol 28 (4) ◽  
pp. 385-392 ◽  
Author(s):  
Anton Hommer ◽  
Doreen Schmidl ◽  
Martina Kromus ◽  
Ahmed M Bata ◽  
Klemens Fondi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Film Thickness ◽  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Eye Drops ◽  
Life Score ◽  
Related Quality ◽  
Preservative Free

Purpose: Long-term glaucoma therapy with preservative-containing eye drops may impact ocular surface health. This study was performed to investigate whether a switch from preserved topical prostaglandin therapy to preservative-free tafluprost therapy improves precorneal tear film thickness in patients with glaucoma or ocular hypertension. Methods: A total of 30 patients who were under topical preservative-containing prostaglandin monotherapy for at least 6 months were included. Patients were then switched from preserved prostaglandin therapy to unpreserved tafluprost drops once daily. Tear film thickness was measured at baseline and 4 and 12 weeks after therapy change with an ultrahigh-resolution optical coherence tomography system. Furthermore, clinical measures of ocular surface disease were determined and symptoms were assessed using the Dry Eye–Related Quality-of-Life Score. Results: After switching to unpreserved tafluprost, tear film thickness significantly increased from 4.7 ± 0.5 to 5.0 ± 0.6 µm 4 weeks after therapy change and still tended to be increased after 12 weeks (4.8 ± 0.7 µm). Breakup time significantly increased from 5.1 ± 2.3 to 7.2 ± 3.4 s and to 10.1 ± 3.6 s after therapy change. In addition, a significant decrease in corneal staining score from 1.8 ± 0.7 to 1.4 ± 0.8 after 4 weeks and to 0.7 ± 0.7 after 12 weeks treatment was observed. Switching to preservative-free drops reduced Dry Eye–Related Quality-of-Life Score from 11.4 ± 11.0 to 5.7 ± 6.4 and to 4.7 ± 7.5. Conclusion: Our data show that switching to preservative-free tafluprost leads to an increase in tear film thickness, breakup time, and an improvement of Dry Eye–Related Quality-of-Life Score. Our results therefore indicate that a switch to unpreserved tafluprost is beneficial for ocular surface health in patients under long-term preserved prostaglandin eye drops.

scholarly journals Autoimmune Epithelitis and Chronic Inflammation in Sjögren’s Syndrome-Related Dry Eye Disease

2021 ◽  
Vol 22 (21) ◽  
pp. 11820
Author(s):  
Yoko Ogawa ◽  
Tsutomu Takeuchi ◽  
Kazuo Tsubota
Keyword(s):  
Chronic Inflammation ◽  
Dry Eye ◽  
Ocular Surface ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Lacrimal Glands ◽  
Meibomian Glands ◽  
Sjögren‘S Syndrome

Autoimmune epithelitis and chronic inflammation are one of the characteristic features of the immune pathogenesis of Sjögren’s syndrome (SS)-related dry eye disease. Autoimmune epithelitis can cause the dysfunction of the excretion of tear fluid and mucin from the lacrimal glands and conjunctival epithelia and meibum from the meibomian glands. The lacrimal gland and conjunctival epithelia express major histocompatibility complex class II or human leukocyte antigen-DR and costimulatory molecules, acting as nonprofessional antigen-presenting cells for T cell and B cell activation in SS. Ocular surface epithelium dysfunction can lead to dry eye disease in SS. Considering the mechanisms underlying SS-related dry eye disease, this review highlights autoimmune epithelitis of the ocular surface, chronic inflammation, and several other molecules in the tear film, cornea, conjunctiva, lacrimal glands, and meibomian glands that represent potential targets in the treatment of SS-related dry eye disease.

Assessment Of Dry Eye Symptoms And Quality Of Sleep In Engineering Students During The Covid-19 Pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1202-1207
Author(s):  
Pavithra S ◽  
Dheepak Sundar M
Keyword(s):  
Sleep Quality ◽  
Dry Eye ◽  
Screen Time ◽  
Engineering Students ◽  
Statistical Tests ◽  
Quality Of Sleep ◽  
Cross Sectional ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

To assess dry eye symptoms (DES) and quality of sleep in engineering students during the Covid19 pandemic lockdown and also to assess the association between DES and sleep quality. A cross-sectional questionnaire-based study was carried out among 396 engineering students studying in Saveetha engineering college. The study tool used was a semi-structured google form questionnaire designed for assessing digital device usage, symptoms of dry eye disease and sleep pattern. Responses were analyzed using appropriate statistical tests. Overall 64.1% attained a score of more than 10, indicating the presence of DES. 70.2% of the study population used digital screens for more than 13 hours. A statistically significant association was found between increased screen time and presence of DES(p<0.05). 64.9% had a score of >18 indicating reduced sleep quality. About 77.1% of the students with DES had reduced sleep quality, and a significant association (p<0.01) was observed between the two. During the Covid19 pandemic lockdown, there appears to be rising prevalence of DES in student population, one of the reasons being increased screen time. The sleep quality was also found to be reduced, and a significant association was found between DES and sleep quality.

Dry Eye Syndrome-Related Quality of Life in Glaucoma Patients

2009 ◽  
Vol 19 (4) ◽  
pp. 572-579 ◽  
Author(s):  
Gemma Caterina Maria Rossi ◽  
Carmine Tinelli ◽  
Gian Maria Pasinetti ◽  
Giovanni Milano ◽  
Paolo Emilio Bianchi
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Ocular Surface ◽  
Cross Sectional Study ◽  
Dry Eye Syndrome ◽  
Control Group ◽  
Ocular Surface Disease Index ◽  
Symptom Scale ◽  
Cross Sectional

Purpose To verify the presence of dry eye syndrome (DES) in treated patients with glaucoma and to analyze DES's impact on the patients' quality of life (QOL) versus the control group. Methods In this observational cross-sectional study, 61 patients were enrolled at a clinical practice. Patients were divided into three groups by number of glaucoma drops instilled per day (G1=1 drop/day, G2=2 drops/day, G3=3 drops/day). A control group of 20 subjects was also selected (G0). All subjects were submitted to a complete ocular examination (including tear function and ocular surface status) and completed the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ), Glaucoma Symptom Scale (GSS) questionnaire, and Ocular Surface Disease Index (OSDI). DES was defined as presence of punctate keratitis and decreased break-up time. Statistical analysis was performed applying the Kruskal-Wallis analysis of variance and Mann-Whitney U tests (to compare median values between groups) as well as the χ2 and Fisher test (to verify significant differences). Results A total of 40% of G3 and 39% of G2 patients presented DES versus 11% of G1 and 5% of G0 (p=0.01). QOL was significantly influenced and altered (NEI-VFQ 25 total mean and GSS total mean and symptoms average: p=0.0085, p=0.006, and p=0.03, respectively). OSDI pointed out differences by group: 26% of G2 and 15% of G3 presented moderate OSDI and 15% of G3 and 8.7% of G2 severe OSDI (p>0.05). Conclusions Patients with topically treated glaucoma present DES more often than a similar control group (p=0.01). The presence of DES negatively influences the patient's QOL. The patients with glaucoma's ocular surface status should be evaluated regularly to ensure the timely detection and treatment of pathologic signs on the ocular surface.

Optimum | Tangible Hydra-PEG™ – Gaining Momentum in the Industry

The Eye ◽  
2021 ◽  
Vol 23 (4) ◽  
pp. 31-34
Author(s):  
M. Conway
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Surface Coating ◽  
Clinical Case ◽  
Contact Lenses ◽  
Ocular Surface Disease ◽  
Corneal Ectasia ◽  
Corneal Lens ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

The issue of hydrophilicity of the surface of gas permeable contact lenses remains one of the persistent problems. Tangible Hydra-PEG™ surface coating is applied to gas permeable contact lenses to significantly improve wettability and wearing comfort. Although it is mainly used to alleviate dry eye symptoms in scleral and corneal lens users, particularly for those patients with corneal ectasia and/or Ocular Surface Disease (OSD), it can be used in other modalities. This article describes the development of the product and describes the benefits of its use in a clinical case.

Updated definition and classification of dry eye disease: Renewed proposals using the nominal group and Delphi techniques

2020 ◽  
pp. 112067212096058
Author(s):  
Stefano Barabino ◽  
Pasquale Aragona ◽  
Antonio di Zazzo ◽  
Maurizio Rolando ◽  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Dry Eye Disease ◽  
Nominal Group ◽  
Eye Disease ◽  
Type I ◽  
Disease Definition ◽  
Quality Of Vision

The aim of our research was to obtain expert consensus for updated definition and classification of dry eye disease using formal methodology. The nominal group technique (NGT) involved a steering committee of four ophthalmologists began with collection of ideas followed by group discussion. The ideas were collated, refined, and voted upon. The main characteristics considered, each with different degrees of severity in types I, II, and III, were the ability or not of the ocular surface to re-equilibrate itself, frequency of symptoms, presence of inflammation, epithelial alterations, and possible alterations in the quality of vision. This was followed by three rounds of a “mini-Delphi” involving an expert panel of 13 ophthalmologists, with the last round including all 17 ophthalmologists. Consensus in the final round of voting (⩾75% of votes) was reached on the definition of dry eye disease and on criteria for its classification in three forms. Type I is a transient and reversible form with subclinical inflammation, possible epithelial alterations, and occasional alterations in vision. Type II is a recurrent form characterized by a reduced ability to re-equilibrate the ocular surface, frequent symptoms and alterations in vision with clinically-evident inflammation, and clear evidence of epithelial alterations. Type III is a chronic form with inability to re-equilibrate the ocular surface and accompanied by clinically-evident and chronic inflammation, persistent epithelial alterations, and frequent alterations in quality of vision. The vast majority of patients with dry eye disease can be easily classified into one of these three forms. Dry eye disease definition was updated accordingly.

Effects of Muller’s muscle-conjunctival resection for ptosis on ocular surface scores and dry eye symptoms

Orbit ◽  
2016 ◽  
Vol 36 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Bruna L. Rymer ◽  
Diane R. Marinho ◽  
Cristina Cagliari ◽  
Samara B. Marafon ◽  
Fernando Procianoy
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Eye Symptoms ◽  
Müller’S Muscle ◽  
Dry Eye Symptoms
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