Androgens’ Effects across the Lifespan in Men and Animal Models

2021 ◽  
Author(s):  
Cheryl A. Frye ◽  
Jennifer K. Torgersen ◽  
Vincent F. Lembo ◽  
Kelly Drew
Keyword(s):  
Individual Differences ◽  
Side Effects ◽  
Animal Models ◽  
Pleiotropic Effects ◽  
Rodent Models ◽  
Long Term Effects ◽  
Clinical Literature

The clinical literature and recent studies in our laboratory using rodent models demonstrate that there are individual differences in androgens’ pleiotropic effects across the lifespan that need to be better understood. The question to address that challenges the field is that levels of androgens (current and/or prior) may not drive differing responses to androgens. The clinical example of Post-finasteride Syndrome, in which side-effects persist long after treatment is discontinued, supports investigations of this novel question relating to long-term effects of androgen manipulations, independent of existing levels of androgens.

scholarly journals Acceptance and Intake of COVID-19 Vaccines among Older Germans

2021 ◽  
Vol 10 (7) ◽  
pp. 1388
Author(s):  
Marta Malesza ◽  
Erich Wittmann
Keyword(s):  
Side Effects ◽  
Long Term Effects ◽  
Negative Side ◽  
Factors Influencing ◽  
Vaccination Acceptance ◽  
Negative Side Effects

The main aim of this study was to investigate the various factors influencing COVID-19 vaccination acceptance and actual intake among older Germans aged over 75 years old (n = 1037). We found that the intention to get vaccinated or intake of the COVID-19 vaccine were positively related to the perceptions of becoming infected, perceptions of the severity of the potential long-term effects, the vaccine’s efficacy, and the benefits of vaccination. Meanwhile, the intention to get the vaccine or vaccine intake were decreased by perceptions of the negative side-effects and the general impediments to vaccination.

Long term effects of early life stress on HPA circuit in rodent models

2021 ◽  
Vol 521 ◽  
pp. 111125
Author(s):  
Lucy Babicola ◽  
Rossella Ventura ◽  
Sebastian Luca D'Addario ◽  
Donald Ielpo ◽  
Diego Andolina ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Rodent Models ◽  
Long Term Effects

VACCINE HESITANCY TO VACCINE DESPERATION! EXPERIENCES FROM 2 VACCINATION CENTERS IN MUMBAI.

2021 ◽  
pp. 43-45
Author(s):  
Reena J. Wani ◽  
Sanjay Panchal ◽  
Kinjal Chauhan ◽  
Varun J. Wani ◽  
Priya H. Manihar ◽  
...  
Keyword(s):  
Side Effects ◽  
Adverse Events ◽  
Hand Hygiene ◽  
Special Reference ◽  
Vaccine Hesitancy ◽  
Long Term Effects ◽  
Social Distancing ◽  
Roll Out ◽  
Available Resources

Since the beginning of the COVID-19 Pandemic and Lockdown on March 2020 till date, measures like hand hygiene, social distancing and testing have worked only partially to contain the cases and deaths. Cooper and Nair Hospitals were amongst the nodal centres identied in January 2021 to launch the Nationwide Vaccination drive in Mumbai. Aim: To highlight the pattern of vaccination roll-out, procedures in various phases and discuss concerns, challenges and effect on our workforce and workplan. Methodology: We reviewed the patterns, uptake of vaccine, procedures and problems faced by our vaccination centres from January 15 till April 30 (4 months). We also looked into adverse events following immunization (AEFI) reported. th th Results: Over 68,000 vaccine doses have been administrated in Cooper alone by April end, and issues were analysed in detail with special reference to logistics & challenges. AEFI were very few. We found that initially anxiety about side effects, concerns about choice of vaccine and long-term effects were the major impediments to vaccination. Later on, the demand exceeded the supply. Conclusion: Although vaccination is not the nal answer, it is an important tool to improve our response to the pandemic. Reviewing, restructuring available resources is essential in pandemic situations. Proper planning, counselling and choice in the way forward in this crisis.

Three new species of Collembola (Arthropoda: Hexapoda) from Central Brazilian shallow caves: side effects of long term application of environmental law on conservation

Zootaxa ◽  
2018 ◽  
Vol 4500 (1) ◽  
pp. 59 ◽  
Author(s):  
DOUGLAS ZEPPELINI ◽  
RONIERE A. BRITO ◽  
ESTEVAM C. A. LIMA
Keyword(s):  
New Species ◽  
Side Effects ◽  
Environmental Law ◽  
High Impact ◽  
Southeastern Brazil ◽  
Long Term Effects ◽  
The Law ◽  
Three New Species

Three new species of Collembola are described from small shallow caves in Southeastern Brazil: Arrhopalites glabrofasciatus sp. nov., Pseudosinella ambigua sp. nov. and Pseudosinella guanhaensis sp. nov. The species were found in surveys performed as part of the process to accomplish the permits for high impact enterprising. The change in the legislation is discussed and a suggestion is made to improve the process. The long term effects of the law resulted in the discovery of many new species and genera, most of them being (or to be) described. 

Aspects of Long-Term Treatment with Neuroleptics Historical and Literature Review—Personal Experience with Fluspirilene and Penfluridol

1975 ◽  
Vol 3 (2) ◽  
pp. 114-124 ◽  
Author(s):  
Lucian Floru
Keyword(s):  
Side Effects ◽  
Literature Review ◽  
Personal Experience ◽  
Term Treatment ◽  
Term Therapy ◽  
Tabular Form ◽  
Long Term Effects ◽  
Long Term Treatment ◽  
Long Term Therapy

The literature on neuroleptics with substance-specific long-term effects (fluspirilene, penfluridol) is reviewed in tabular form. This is followed by a report of personal investigations on 76 schizophrenics who were treated with fluspirilene initially within the hospital and later on an out-patient basis, on 86 patients who were treated with it exclusively at the out-patients' department, as well as on 123 schizophrenic psychoses treated with penfluridol in the out-patients' department. The side-effects caused by the two substances are compared. Pre-requisites for effective long-term therapy with a few complications are discussed.

Long-term effects of cancer therapy on dental development: a case report

2004 ◽  
Vol 28 (4) ◽  
pp. 351-353 ◽  
Author(s):  
Sedat Cetiner ◽  
Cansu Alpaslan
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Cancer Therapy ◽  
Dental Development ◽  
Long Term Effects ◽  
Antineoplastic Treatment ◽  
Malignant Condition

As the prognosis of malignant conditions in children improve by cancer therapy, long-term side effects due to antineoplastic treatment may be encountered. This case report demonstrates the long-term alterations on dental development in patient who had been treated for malignant condition. Alterations were observed during radiographic control 8 years after the therapy and included short, blunted, tapered and V-shaped root malformations as well as delayed and ectopic eruptions.

Long-Term Effects of Cografts of Pretransected Peripheral Nerve with Adrenal Medulla in Animal Models of Parkinsonʼs Disease

Neurosurgery ◽  
1993 ◽  
Vol 33 (4) ◽  
pp. 685-690 ◽  
Author(s):  
Isao Date ◽  
Yusuke Yoshimoto ◽  
Yuji Gohda ◽  
Tomohisa Furuta ◽  
Shoji Asari ◽  
...  
Keyword(s):  
Animal Models ◽  
Peripheral Nerve ◽  
Adrenal Medulla ◽  
Long Term Effects

scholarly journals No Additional Evidence that Proximity to the July 4th Holiday Affects Affective Polarization

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Mark J. Brandt ◽  
Felicity M. Turner-Zwinkels
Keyword(s):  
Individual Differences ◽  
Social Distance ◽  
Longitudinal Design ◽  
American Identity ◽  
Long Term Effects ◽  
Short Term ◽  
Future Studies ◽  
Close Proximity ◽  
Within Subjects

One promising approach for reducing affective polarization is priming a shared American identity and one promising event to prime that identity is the 4th of July. Prior work showed that proximity to the 4th of July reduced affective polarization. We conceptually replicated this study using a 9-wave longitudinal design in 2019. We found no short-term or long-term effects of the 4th of July on social distance from partisan and ideological ingroups or outgroups. Notably, our within-subjects design was able to identify the existence of individual differences in social distance trajectories across time, but there were not individual differences in short-terms changes in social distance in close proximity to the 4th of July. Additional analyses, did not find consistent predictors of these individual differences, suggesting a clear gap for future studies. Although priming a shared American identity may be effective, these findings suggest that the salutary effects of the 4th of July holiday do not emerge in 2019.

Slow-Release Terbutaline and Theophylline for the Long-Term Therapy of Children With Asthma: A Latin Square and Factorial Study of Drug Effects and Interactions

PEDIATRICS ◽  
1989 ◽  
Vol 84 (1) ◽  
pp. 119-125
Author(s):  
Olivia Kit Wun Chow ◽  
Kam Pui Fung
Keyword(s):  
Side Effects ◽  
Slow Release ◽  
Clinical Symptoms ◽  
Combined Therapy ◽  
Latin Square ◽  
Term Therapy ◽  
Long Term Effects ◽  
Long Term Treatment ◽  
Children With Asthma

To evaluate the long-term effects of slow-release formulations of theophylline and terbutaline on pulmonary function, clinical symptoms, and side effects, 24 children with stable and moderately severe perennial asthma participated in a prospective double-blind crossover study. The patients and the treatments were randomized according to the Latin square design to eliminate all possible period/climate biases throughout the protracted study period. The treatments consisted of terbutaline, 5 mg, theophylline, 200 mg, the combination, and placebo, given twice daily orally and crossing over every 28 days. The two drugs, administered alone or in combination, improved lung function and symptoms when compared with placebo. The interaction of theophylline and terbutaline was quantitatively shown by 2 x 2 factorial statistical design to be essentially additive rather than synergistic in the control of asthma. No increase in side effects was noted when the combined therapy was used. These findings suggest therapeutic advantages to combining submaximal oral doses of sustained-release theophylline and terbutaline for the long-term treatment of children with asthma.

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