scholarly journals Acceptance and Intake of COVID-19 Vaccines among Older Germans

2021 ◽  
Vol 10 (7) ◽  
pp. 1388
Author(s):  
Marta Malesza ◽  
Erich Wittmann
Keyword(s):  
Side Effects ◽  
Long Term Effects ◽  
Negative Side ◽  
Factors Influencing ◽  
Vaccination Acceptance ◽  
Negative Side Effects

The main aim of this study was to investigate the various factors influencing COVID-19 vaccination acceptance and actual intake among older Germans aged over 75 years old (n = 1037). We found that the intention to get vaccinated or intake of the COVID-19 vaccine were positively related to the perceptions of becoming infected, perceptions of the severity of the potential long-term effects, the vaccine’s efficacy, and the benefits of vaccination. Meanwhile, the intention to get the vaccine or vaccine intake were decreased by perceptions of the negative side-effects and the general impediments to vaccination.

scholarly journals Acceptance and intake of COVID-19 vaccines among older Germans

2021 ◽  
Author(s):  
Marta Malesza ◽  
Erich Wittmann
Keyword(s):  
Side Effects ◽  
Long Term Effects ◽  
Negative Side ◽  
Factors Influencing ◽  
Vaccination Acceptance ◽  
Negative Side Effects

AbstractThe main aim of this study was to investigate the various factors influencing COVID-19 vaccination acceptance and actual intake among older Germans aged over 75 years old (N = 1037). We found that the intention to get vaccinated or intake of the COVID-19 vaccine were positively related to the perceptions of becoming infected, perceptions of the severity of the potential long-term effects, the vaccine’s efficacy, and the benefits of vaccination. Meanwhile, the intention to get the vaccine or vaccine intake were decreased by perceptions of the negative side-effects and the general impediments to vaccination.

Biological Significance of Reducing Glucose Degradation Products in Peritoneal Dialysis Fluids

2000 ◽  
Vol 20 (5_suppl) ◽  
pp. 23-27 ◽  
Author(s):  
Anders Wieslander ◽  
Torbjörn Linden ◽  
Barbara Musi ◽  
Ola Carlsson ◽  
Reinhold Deppisch
Keyword(s):  
Peritoneal Dialysis ◽  
Side Effects ◽  
Host Defense ◽  
Degradation Products ◽  
Biological Significance ◽  
Peritoneal Membrane ◽  
Negative Side ◽  
Glucose Degradation Products ◽  
Negative Side Effects

Carbohydrates are not stable when exposed to energy; they degrade into new molecules. In peritoneal dialysis (PD) fluids, degradation of glucose occurs during the heat sterilization procedure. The biological consequences of this degradation are side effects such as impaired proliferation and impaired host defense mechanisms, demonstrated in vitro for a great variety of cells. Several highly toxic compounds—such as formaldehyde and 3-deoxyglucosone—have been identified in PD fluids. Carbonyl compounds, apart from being cytotoxic, are also well-known promoters of irreversible advanced glycation end-products (AGEs), which might participate in the long-term remodeling of the peritoneal membrane. Various approaches can be used to reduce the formation of glucose degradation products (GDPs) during heat sterilization. Some examples are shortening the sterilization time, lowering the pH, removing catalyzing substances, and increasing glucose concentration. The latter three factors are employed in the multi-compartment bag with a separate chamber containing pure glucose at high concentration and low pH. Gambrosol trio, a PD fluid produced in this way, shows reduced cytotoxicity, normalized host defense reactions, less AGE formation, and reduced concentrations of formaldehyde and 3-deoxyglucosone. Moreover, in the clinical situation, the fluid turns out to be more biocompatible for the patient, causing less mesothelial cell damage, which in the long term could lead to a more intact peritoneal membrane. Conclusion Glucose degradation products in heat-sterilized fluids for peritoneal dialysis are cytotoxic, promote AGE formation, and cause negative side effects for the patient. Using improved and well-controlled manufacturing processes, it is possible to produce sterile PD fluids with glucose as the osmotic agent but without the negative side effects related to GDPs.

scholarly journals Informal risk-sharing between smallholders may be threatened by formal insurance: Lessons from a stylized agent-based model

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248757
Author(s):  
Meike Will ◽  
Jürgen Groeneveld ◽  
Karin Frank ◽  
Birgit Müller
Keyword(s):  
Side Effects ◽  
Low Income ◽  
Risk Sharing ◽  
Agent Based Model ◽  
Long Term Effects ◽  
Agent Based ◽  
Positive Effects ◽  
Negative Side Effects ◽  
Informal Risk Sharing

Microinsurance is promoted as a valuable instrument for low-income households to buffer financial losses due to health or climate-related risks. However, apart from direct positive effects, such formal insurance schemes can have unintended side effects when insured households lower their contribution to traditional informal arrangements where risk is shared through private monetary support. Using a stylized agent-based model, we assess impacts of microinsurance on the resilience of those smallholders in a social network who cannot afford this financial instrument. We explicitly include the decision behavior regarding informal transfers. We find that the introduction of formal insurance can have negative side effects even if insured households are willing to contribute to informal risk arrangements. However, when many households are simultaneously affected by a shock, e.g. by droughts or floods, formal insurance is a valuable addition to informal risk-sharing. By explicitly taking into account long-term effects of short-term transfer decisions, our study allows to complement existing empirical research. The model results underline that new insurance programs have to be developed in close alignment with established risk-coping instruments. Only then can they be effective without weakening functioning aspects of informal risk management, which could lead to increased poverty.

Receptor research for the development of new drug therapies for stimulant addiction

Impact ◽  
2021 ◽  
Vol 2021 (6) ◽  
pp. 43-45
Author(s):  
Kyoji Okita
Keyword(s):  
Side Effects ◽  
Drug Addiction ◽  
Drug Users ◽  
Long Term Effects ◽  
Imaging Center ◽  
Positron Emission ◽  
Negative Side Effects ◽  
Receptor Research ◽  
Methamphetamine Use Disorder

Drug addiction is associated with a range of medical and social problems, not least the negative side effects experienced by those who take drugs. The long-term effects are particularly concerning and can be difficult to treat. Changes in the behaviour of long-term drug users can include impulsivity and irrationality, which can negatively impact on society. Dr Kyoji Okita, Integrative Brain Imaging Center (IBIC), National Center of Neurology and Psychiatry, Japan, is working to shed light on the neurological biochemistry behind drug addiction, as this aspect is little understood. In his work, he is collaborating with experts and he intends to apply the knowledge he and his collaborators uncover to real-world treatments. A particular focus for Okita is the use of positron emission tomography (PET) to explore the dynamics behind psychological and addiction biology. Currently, he is investigating the potential of a drug called Istradefylline as a treatment for methamphetamine use disorder. The drug is currently used as part of the treatment for Parkinson's disease and Okita wants to decipher if administering Istradefylline to people addicted to methamphetamines can help increase their dopamine sensitivity and, in the process, reduce their reliance on the drug, as well as the psychological side effects. If found to be effective, Istradefylline could form a key part of a treatment programme for addiction.

Scam Alert 2022 !! Best Health Keto UK Reviews – Negative Side Effects or Safe Diet Pills? Is £39.76 Worthy for “Best Health Keto United Kingdom” Customers? Read This Before Buy v1

2022 ◽  
Author(s):  
health not provided
Keyword(s):  
Weight Loss ◽  
United Kingdom ◽  
Side Effects ◽  
Fat Cells ◽  
Promote Weight Loss ◽  
Negative Side ◽  
Negative Side Effects ◽  
Official Site ◽  
Diet Pills ◽  
Loss Formula

Best Health Keto UK Reviews is an all-natural weight loss formula and it works in an efficient way to promote weight loss and burn off stubborn fat cells. Best Health Keto works by allowing your body to enter into the ketosis process. Must See: Visit the Official Site of Best Health Keto [Up to 70% Discount Available Here]

Essential CBD Extract Gummies [Australia] AU Reviews – Hidden Negative Side Effects Or Real Benefits? v1

2021 ◽  
Author(s):  
hengstla not provided
Keyword(s):  
Side Effects ◽  
Negative Side ◽  
Negative Side Effects ◽  
Money Back Guarantee

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VACCINE HESITANCY TO VACCINE DESPERATION! EXPERIENCES FROM 2 VACCINATION CENTERS IN MUMBAI.

2021 ◽  
pp. 43-45
Author(s):  
Reena J. Wani ◽  
Sanjay Panchal ◽  
Kinjal Chauhan ◽  
Varun J. Wani ◽  
Priya H. Manihar ◽  
...  
Keyword(s):  
Side Effects ◽  
Adverse Events ◽  
Hand Hygiene ◽  
Special Reference ◽  
Vaccine Hesitancy ◽  
Long Term Effects ◽  
Social Distancing ◽  
Roll Out ◽  
Available Resources

Since the beginning of the COVID-19 Pandemic and Lockdown on March 2020 till date, measures like hand hygiene, social distancing and testing have worked only partially to contain the cases and deaths. Cooper and Nair Hospitals were amongst the nodal centres identied in January 2021 to launch the Nationwide Vaccination drive in Mumbai. Aim: To highlight the pattern of vaccination roll-out, procedures in various phases and discuss concerns, challenges and effect on our workforce and workplan. Methodology: We reviewed the patterns, uptake of vaccine, procedures and problems faced by our vaccination centres from January 15 till April 30 (4 months). We also looked into adverse events following immunization (AEFI) reported. th th Results: Over 68,000 vaccine doses have been administrated in Cooper alone by April end, and issues were analysed in detail with special reference to logistics & challenges. AEFI were very few. We found that initially anxiety about side effects, concerns about choice of vaccine and long-term effects were the major impediments to vaccination. Later on, the demand exceeded the supply. Conclusion: Although vaccination is not the nal answer, it is an important tool to improve our response to the pandemic. Reviewing, restructuring available resources is essential in pandemic situations. Proper planning, counselling and choice in the way forward in this crisis.

Three new species of Collembola (Arthropoda: Hexapoda) from Central Brazilian shallow caves: side effects of long term application of environmental law on conservation

Zootaxa ◽  
2018 ◽  
Vol 4500 (1) ◽  
pp. 59 ◽  
Author(s):  
DOUGLAS ZEPPELINI ◽  
RONIERE A. BRITO ◽  
ESTEVAM C. A. LIMA
Keyword(s):  
New Species ◽  
Side Effects ◽  
Environmental Law ◽  
High Impact ◽  
Southeastern Brazil ◽  
Long Term Effects ◽  
The Law ◽  
Three New Species

Three new species of Collembola are described from small shallow caves in Southeastern Brazil: Arrhopalites glabrofasciatus sp. nov., Pseudosinella ambigua sp. nov. and Pseudosinella guanhaensis sp. nov. The species were found in surveys performed as part of the process to accomplish the permits for high impact enterprising. The change in the legislation is discussed and a suggestion is made to improve the process. The long term effects of the law resulted in the discovery of many new species and genera, most of them being (or to be) described. 

scholarly journals Antioxidative and antimicrobial potentials of Parmelia saxatilis and Pseudoevernia furfuracea

2016 ◽  
pp. 9-18
Author(s):  
Jasmina Cilerdzic ◽  
Mirjana Stajic ◽  
Jelena Vukojevic
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Side Effects ◽  
Klebsiella Pneumoniae ◽  
Bacterial Species ◽  
Phenol Content ◽  
Negative Side Effects ◽  
Highly Correlated ◽  
Ethanol Extracts

Even though numerous lichen species possess significant medical potentials they are still unexplored, and particularly species and strains originating from Serbia. Therefore, the aim of this study was to evaluate the antioxidative and antimicrobial potential of ethanol extracts of Parmelia saxatilis and Pseudoevernia furfuracea collected in Serbia. The tested extracts were good scavengers of DPPH radicals, with capacities ranging from 14.76% to 79.76% in P. saxatilis and from 21.39% to 90.04% in P. furfuracea. In P. saxatilis level of DPPH? neutralisation was highly correlated with phenol content (r2 = 0.9981) and in P. furfuracea with amount of total flavonoides (r2 = 0.9641). The extract of P. furfuracea inhibited the growth of all tested microorganisms with exception of Aspergillus flavus, while P. saxatilis extract affected only growth of bacterial species. Among tested microorganisms, Staphylococcus aureus and Klebsiella pneumoniae were the most sensitive, while Enterococcus faecalis, Pseudomonas aeruginosa as well as micromycetes were the least sensitive to tested extracts. Because of these potentials and the fact that their long term usage does not have any negative side effects on organism and development of microbial resistance, the extracts could be included in conventional therapy.

scholarly journals A Multi-Objective Approach to Mitigate Negative Side Effects

2020 ◽  
Author(s):  
Sandhya Saisubramanian ◽  
Ece Kamar ◽  
Shlomo Zilberstein
Keyword(s):  
Side Effects ◽  
Empirical Evaluation ◽  
Primary Objective ◽  
Maximum Deviation ◽  
Negative Side ◽  
Multi Objective ◽  
Markov Decision ◽  
Secondary Objective ◽  
Negative Side Effects ◽  
The Impact

Agents operating in unstructured environments often create negative side effects (NSE) that may not be easy to identify at design time. We examine how various forms of human feedback or autonomous exploration can be used to learn a penalty function associated with NSE during system deployment. We formulate the problem of mitigating the impact of NSE as a multi-objective Markov decision process with lexicographic reward preferences and slack. The slack denotes the maximum deviation from an optimal policy with respect to the agent's primary objective allowed in order to mitigate NSE as a secondary objective. Empirical evaluation of our approach shows that the proposed framework can successfully mitigate NSE and that different feedback mechanisms introduce different biases, which influence the identification of NSE.

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