scholarly journals Dopamine: The Amazing Molecule

2021 ◽  
Author(s):  
Mehveş Ece Genç ◽  
Emine Nur Özdamar
Keyword(s):  
Second Messengers ◽  
Reward System ◽  
Nigrostriatal Pathway ◽  
Metabotropic Receptors ◽  
Hyperactivity Disorder ◽  
Mesolimbic Pathway ◽  
The Central Nervous System ◽  
Psychiatric Conditions ◽  
Mesocortical Pathway ◽  
Motivational Behavior

Dopamine (DA) is a neurotransmitter in the central nervous system (CNS) and has been implicated in the pathogenesis of various diseases of motor functions and psychiatric conditions. Dopamine is also the key modulator for motivational behavior and brain reward system and regulates food intake as well. It has some neuroendocrine function too. It is noteworthy that dopamine has so many diverse roles in the CNS. DA has various pathways such as the Nigrostriatal pathway, Mesolimbic pathway, Mesocortical pathway and Tuberohypophyseal pathway. It has D1, D2, D3, D4 and D5 metabotropic receptors and interacts with cholinergic, GABAergic, opioidergic and glutamatergic systems. DA also activates diverse second messengers and pathways. These complicated interactions partly explain its diverse actions. The aim of the present chapter is to summarize data on the contribution of DA in the pathogenesis of many conditions such as Parkinson’s disease, Schizophrenia, Attention Deficit Hyperactivity Disorder and addiction.

scholarly journals Altered urinary tetrahydroisoquinoline derivatives in patients with Tourette syndrome: reflection of dopaminergic hyperactivity?

2020 ◽  
Author(s):  
Philipp Capetian ◽  
Veit Roessner ◽  
Caroline Korte ◽  
Susanne Walitza ◽  
Franz Riederer ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Diagnostic Value ◽  
Tic Disorders ◽  
Operating Characteristics ◽  
Roc Curve Analysis ◽  
Two Phase ◽  
Dopaminergic Neurotransmission ◽  
Hyperactivity Disorder ◽  
The Central Nervous System ◽  
Chronic Tic Disorders

AbstractTetrahydroisoquinolines (TIQs) such as salsolinol (SAL), norsalsolinol (NSAL) and their methylated derivatives N-methyl-norsalsolinol (NMNSAL) and N-methyl-salsolinol (NMSAL), modulate dopaminergic neurotransmission and metabolism in the central nervous system. Dopaminergic neurotransmission is thought to play an important role in the pathophysiology of chronic tic disorders, such as Tourette syndrome (TS). Therefore, the urinary concentrations of these TIQ derivatives were measured in patients with TS and patients with comorbid attention-deficit/hyperactivity disorder (TS + ADHD) compared with controls. Seventeen patients with TS, 12 with TS and ADHD, and 19 age-matched healthy controls with no medication took part in this study. Free levels of NSAL, NMNSAL, SAL, and NMSAL in urine were measured by a two-phase chromatographic approach. Furthermore, individual TIQ concentrations in TS patients were used in receiver-operating characteristics (ROC) curve analysis to examine the diagnostic value. NSAL concentrations were elevated significantly in TS [434.67 ± 55.4 nmol/l (standard error of mean = S.E.M.), two-way ANOVA, p < 0.0001] and TS + ADHD patients [605.18 ± 170.21 nmol/l (S.E.M.), two-way ANOVA, p < 0.0001] compared with controls [107.02 ± 33.18 nmol/l (S.E.M.), two-way ANOVA, p < 0.0001] and NSAL levels in TS + ADHD patients were elevated significantly in comparison with TS patients (two-way ANOVA, p = 0.017). NSAL demonstrated an AUC of 0.93 ± 0.046 (S.E.M) the highest diagnostic value of all metabolites for the diagnosis of TS. Our results suggest a dopaminergic hyperactivity underlying the pathophysiology of TS and ADHD. In addition, NSAL concentrations in urine may be a potential diagnostic biomarker of TS.

Session 2: How Can Parents Help? First Parent/Adolescent Session

2020 ◽  
pp. 29-36
Author(s):  
Susan E. Sprich ◽  
Steven A. Safren
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Reward System ◽  
Joint Meeting ◽  
Hyperactivity Disorder ◽  
Educational Information

In this session, a joint meeting is held with the adolescent client and their parent or parents. The chapter includes educational information for the parents about attention-deficit/hyperactivity disorder (ADHD) and an overview of the treatment for the parents. The primary goal of the session is to ensure that all involved parties are “on the same page.” Parent and adolescent goals are set, and the use of a motivational/reward system is discussed. The chapter concludes with a discussion of the role that parents will play in the adolescent’s treatment.

scholarly journals Physiology of Astroglial Excitability

Function ◽  
2020 ◽  
Vol 1 (2) ◽  
Author(s):  
Alexei Verkhratsky ◽  
Alexey Semyanov ◽  
Robert Zorec
Keyword(s):  
Cyclic Amp ◽  
Second Messengers ◽  
Synaptic Connectivity ◽  
Neural Cells ◽  
Intracellular Signals ◽  
Multiple Receptors ◽  
Concentration Of Ions ◽  
The Central Nervous System ◽  
Evidence Review ◽  
Underlying Mechanisms

Abstract Classic physiology divides all neural cells into excitable neurons and nonexcitable neuroglia. Neuroglial cells, chiefly responsible for homeostasis and defense of the nervous tissue, coordinate their complex homeostatic responses with neuronal activity. This coordination reflects a specific form of glial excitability mediated by complex changes in intracellular concentration of ions and second messengers organized in both space and time. Astrocytes are equipped with multiple molecular cascades, which are central for regulating homeostasis of neurotransmitters, ionostasis, synaptic connectivity, and metabolic support of the central nervous system. Astrocytes are further provisioned with multiple receptors for neurotransmitters and neurohormones, which upon activation trigger intracellular signals mediated by Ca2+, Na+, and cyclic AMP. Calcium signals have distinct organization and underlying mechanisms in different astrocytic compartments thus allowing complex spatiotemporal signaling. Signals mediated by fluctuations in cytosolic Na+ are instrumental for coordination of Na+ dependent astrocytic transporters with tissue state and homeostatic demands. Astroglial ionic excitability may also involve K+, H+, and Cl−. The cyclic AMP signalling system is, in comparison to ions, much slower in targeting astroglial effector mechanisms. This evidence review summarizes the concept of astroglial intracellular excitability.

Transduction mechanisms in airway sensory nerves

2006 ◽  
Vol 101 (3) ◽  
pp. 950-959 ◽  
Author(s):  
Thomas Taylor-Clark ◽  
Bradley J. Undem
Keyword(s):  
Action Potential ◽  
Action Potentials ◽  
Membrane Depolarization ◽  
Sensory Nerves ◽  
Metabotropic Receptors ◽  
Metabotropic Receptor ◽  
Transduction Mechanisms ◽  
The Central Nervous System ◽  
Action Potential Initiation ◽  
Potential Initiation

The induction of action potentials in airway sensory nerves relies on events leading to the opening of cation channels in the nerve terminal membrane and subsequent membrane depolarization. If the membrane depolarization is of sufficient rate and amplitude, action potential initiation will occur. The action potentials are then conducted to the central nervous system, leading to the initiation of various sensations and cardiorespiratory reflexes. Triggering events in airway sensory nerves include mechanical perturbation, inflammatory mediators, pH, temperature, and osmolarity acting through a variety of ionotropic and metabotropic receptors. Action potential initiation can be modulated (positively or negatively) through independent mechanisms caused mainly by autacoids and other metabotropic receptor ligands. Finally, gene expression of sensory nerves can be altered in adult mammals. This neuroplasticity can change the function of sensory nerves and likely involve both neurotrophin and use-dependent mechanisms. Here we provide a brief overview of some of the transduction mechanisms underlying these events.

scholarly journals BIOLOGICAL MARKERS OF NON-CARCEROGENIC NEGATIVE IMPACTS ON THE CENTRAL NERVOUS SYSTEM OF CHILDREN IN THE AREA WITH EXPOSURE TO ALUMINUM PRODUCTION EMISSIONS

2018 ◽  
Vol 97 (5) ◽  
pp. 461-469
Author(s):  
I. G. Zhdanova-Zaplesvichko ◽  
Marina A. Zemlyanova ◽  
Yu. V. Koldibekova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Aluminum Content ◽  
Negative Impact ◽  
Neuron Specific Enolase ◽  
Aluminum Production ◽  
Atmospheric Air ◽  
Hyperactivity Disorder ◽  
The Central Nervous System

Introduction. The priority indicator of the influence of chemical factors of the environment on the health of the population of Russia is the pollution of atmospheric air, the composition of which is largely determined by regional features of production. Material and methods. A comparative hygienic assessment of the quality of the atmospheric air of the territory with the placement of aluminum production and the territory without similar sources of emissions was conducted; a chemical-analytical and clinical laboratory examination of 135 children was carried out, with an assessment of the negative effects from the nervous system in the case of aerogenic exposure to aluminum and manganese. Results. In the conditions of the existing quality of atmospheric air in the residential area in the zone of influence of aluminum production which forms an aerogenic exposure of substances (aluminum and manganese), possessing of the unidirectional negative impact on the central nervous system, at the level of 0.0015g/(kg∙day) the share of aluminum is 93.3%, which indicates its primary impact on the population. Children of the observation group 1 showed urine aluminum content by 3.1 times more than in comparison to observation subgroup 2 and 6.9 times in relation to the comparison group (p = 0.0001). The concentration of aluminum as a marker of inhalation exposure is substantiated, and its value more than 0.053 mg/dm3 in urine may indicate an increased risk of neurotoxic exposure. An increased prevalence (1.6-5.5 times) of the negative impact on the CNS in the form of the asthenic autonomous syndrome, as a predictor of attention deficit and hyperactivity disorder, has been shown to be associated with the aerogenic exposure to aluminum. In children with an elevated aluminum content in urine comparing to the reference level, revealed laboratory abnormalities and indices were proved to be associated with an elevated concentration of aluminum in the urine relative to the children of the comparison group: an increase in the level of neuron-specific enolase in the serum indicating an increase in the activity of damage to the blood-brain barrier; an increase in the glutamic acid content by 1.3 times, characterizing the imbalance of the neurotransmitters of the central nervous system; reduction in serum phosphorus, reflecting the antagonistic effect of aluminum, followed by an increase in the level of ionized calcium in the blood. The contribution of aluminum to the biochemical and functional indices deviation from the physiological norm accounted for from 10% to 58%. On the basis of a consistent chain of reliable dependencies, a complex of biomarkers of the asthenic autonomous syndrome and attention deficit and hyperactivity disorder associated with an elevated aluminum content in urine, including glutamic acid, neuron-specific enolase, and phosphorus is substantiated.

scholarly journals The general impact of haploinsufficiency on brain connectivity underlies the pleiotropic effect of neuropsychiatric CNVs

2020 ◽  
Author(s):  
Clara Moreau ◽  
Guillaume Huguet ◽  
Sebastian Urchs ◽  
Elise Douard ◽  
Hanad Sharmarke ◽  
...  
Keyword(s):  
Brain Connectivity ◽  
Copy Number Variants ◽  
Neuropsychiatric Disorders ◽  
Pleiotropic Effect ◽  
Autism Spectrum ◽  
Hyperactivity Disorder ◽  
Severity Scores ◽  
Psychiatric Conditions ◽  
The Mean ◽  
Neutral Effect

AbstractCopy number variants (CNVs) are among the most highly penetrant genetic risk factors for neuropsychiatric disorders. Their impact on brain connectivity remains mostly unstudied. Because they confer risk for overlapping conditions, we hypothesized that they may converge on shared connectivity patterns.We performed connectome-wide analyses using resting-state functional MRI data from 436 carriers of neuropsychiatric CNVs at the 1q21.1, 15q11.2, 16p11.2, 22q11.2 loci, 4 “neutral effect” CNVs, 66 carriers of scarcer neuropsychiatric CNVs, 756 individuals with idiopathic autism spectrum disorder (ASD), schizophrenia, attention deficit hyperactivity disorder, and 5,377 controls. Neuropsychiatric CNVs showed global shifts of mean connectivity. The effect size of CNVs on relative connectivity (adjusted for the mean) was correlated with the known level of neuropsychiatric risk conferred by CNVs. Individuals with idiopathic schizophrenia and ASD had similarities in connectivity with neuropsychiatric CNVs. We reported a linear relationship between connectivity and intolerance to haploinsufficiency measured for all genes encompassed by CNVs across 18 loci. This profile involved the thalamus, the basal ganglia, somatomotor and frontoparietal networks and was correlated with lower general intelligence and higher autism severity scores. An exploratory factor analysis confirmed the contribution of these regions to three latent components shared across CNVs and neuropsychiatric disorders.We posit that deleting genes intolerant to haploinsufficiency reorganize connectivity along general dimensions irrespective of where deletions occur in the genome. This haploinsufficiency brain signature opens new avenues to understand polygenicity in psychiatric conditions and the pleiotropic effect of CNVs on cognition and risk for neuropsychiatric disorders.One sentence summaryNeuropsychiatric CNVs across the genome reorganize brain connectivity architecture along dominant patterns contributing to complex idiopathic conditions.

scholarly journals PrPC as a Transducer of Physiological and Pathological Signals

2021 ◽  
Vol 14 ◽  
Author(s):  
Jessica D. Panes ◽  
Paulina Saavedra ◽  
Benjamin Pineda ◽  
Kathleen Escobar ◽  
Magdalena E. Cuevas ◽  
...  
Keyword(s):  
Neuronal Excitability ◽  
Physiological Role ◽  
Cellular Prion Protein ◽  
Amyloid Peptide ◽  
Metabotropic Receptors ◽  
Cellular Analysis ◽  
The Central Nervous System ◽  
Health And Disease ◽  
Β Amyloid Peptide

After the discovery of prion phenomenon, the physiological role of the cellular prion protein (PrPC) remained elusive. In the past decades, molecular and cellular analysis has shed some light regarding interactions and functions of PrPC in health and disease. PrPC, which is located mainly at the plasma membrane of neuronal cells attached by a glycosylphosphatidylinositol (GPI) anchor, can act as a receptor or transducer from external signaling. Although the precise role of PrPC remains elusive, a variety of functions have been proposed for this protein, namely, neuronal excitability and viability. Although many issues must be solved to clearly define the role of PrPC, its connection to the central nervous system (CNS) and to several misfolding-associated diseases makes PrPC an interesting pharmacological target. In a physiological context, several reports have proposed that PrPC modulates synaptic transmission, interacting with various proteins, namely, ion pumps, channels, and metabotropic receptors. PrPC has also been implicated in the pathophysiological cell signaling induced by β-amyloid peptide that leads to synaptic dysfunction in the context of Alzheimer’s disease (AD), as a mediator of Aβ-induced cell toxicity. Additionally, it has been implicated in other proteinopathies as well. In this review, we aimed to analyze the role of PrPC as a transducer of physiological and pathological signaling.

scholarly journals Amitriptyline Dependence and Its Associations: A Case Report and Literature Review

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
T. Umaharan ◽  
S. Sivayokan ◽  
S. Sivansuthan
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Literature Review ◽  
Case Reports ◽  
Drug Dispensing ◽  
The Central Nervous System ◽  
Psychiatric Conditions

Amitriptyline, the second antidepressant invented next to imipramine, is indicated in many psychiatric conditions as well as for some organic disorders. The drug acts by increasing the availability of monoamines in the central nervous system postsynaptic clefts. Amitriptyline has long been suspected for abusive potential based on a few case reports, and the reports add evidence in favor of the hypothesis. This case report brings such material to the arena of evidence and discusses the probable mechanisms by which patients turn to abusing and be addicted to the drug. The article also argues matters associated with drug dispensing that might raise the risk of misuse of the drug, especially in countries where strict legislation for accessibility of prescribed drugs is not in practice.

Safety of paracetamol during pregnancy: literature review

2020 ◽  
Vol 19 (6) ◽  
pp. 96-101
Author(s):  
M.V. Lukina ◽  
◽  
T.B. Andrushchishina ◽  
I.A. Dronov ◽  
O.A. Vartanova ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Autism Spectrum ◽  
Functional Disorders ◽  
Hyperactivity Disorder ◽  
Drug Of Choice ◽  
Key Words Acetaminophen ◽  
The Central Nervous System ◽  
Clinical Conditions

Paracetamol (acetaminophen) is the drug of choice in pregnant women as an antipyretic and analgesic agent for various clinical conditions. However, long-term paracetamol administration during pregnancy was found to be associated with disorders in children, such as attention deficit hyperactivity disorder (RR = 1.32, 95% CI 1.18–1.45, I2 = 61%); autism spectrum disorders (RR = 1.23, 95% CI 1.13–1.32, I2 = 17%); hyperactivity disorder (RR = 1.24, 95% CI 1.02–1.46, I2 = 95%), and behavioral disorders (RR = 1.28, 95% CI 1.05–1.52, I2 = 94%). Studies conducted so far failed to identify the effect of paracetamol dose in different trimesters of pregnancy on the development of long-term functional disorders of the central nervous system in children. Further studies are needed to assess the importance of social factors and the environment and their contribution to the development of functional disorders of the central nervous system in children. Key words: acetaminophen, safety, pregnancy, neuropsychiatric development of children, paracetamol

Microglial activation in the neurodevelopment: A narrative review

2021 ◽  
Vol 21 ◽  
Author(s):  
Airam Barbosa de Moura ◽  
Morgana Sonza Abitante ◽  
Ritele Hernandez Silva ◽  
João Quevedo ◽  
Gislaine Zilli Réus
Keyword(s):  
Gut Microbiota ◽  
Glial Cells ◽  
Adult Life ◽  
Ethanol Exposure ◽  
Neuron Morphology ◽  
Cellular Debris ◽  
Phases Of Development ◽  
The Central Nervous System ◽  
Psychiatric Conditions ◽  
As Stress

: Microglia are immune cells found in the central nervous system (CNS) involved in infection combat and cellular debris clean. These glial cells are involved in synaptogenesis during brain development by their interactions with neurons and other glial cells. These relations are associated with the secretion of signaling molecules, such as chemokines and neurotrophic factors. Microglia cells influence synapsis and neuron morphology during different phases of development. Also, other systems, for example, gut microbiota indirectly affect microglial functions and morphology. Several factors that can occur in different development periods, including intrauterine through adult life, could impact microglia. Impairment in these cells could be associated with the development of some psychiatric conditions, such as schizophrenia, autistic spectrum disorder (ASD), and depression. This review is focusing on describing microglia functions in the maintenance of CNS and how they are associated with other systems, as the gut-microbiota brain axis and environmental stressors, such as stress, maternal deprivation, sleep deprivation, immune activation, and ethanol exposure, that can influence the function of the microglia during neurodevelopment.

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