scholarly journals Amitriptyline Dependence and Its Associations: A Case Report and Literature Review

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
T. Umaharan ◽  
S. Sivayokan ◽  
S. Sivansuthan

Amitriptyline, the second antidepressant invented next to imipramine, is indicated in many psychiatric conditions as well as for some organic disorders. The drug acts by increasing the availability of monoamines in the central nervous system postsynaptic clefts. Amitriptyline has long been suspected for abusive potential based on a few case reports, and the reports add evidence in favor of the hypothesis. This case report brings such material to the arena of evidence and discusses the probable mechanisms by which patients turn to abusing and be addicted to the drug. The article also argues matters associated with drug dispensing that might raise the risk of misuse of the drug, especially in countries where strict legislation for accessibility of prescribed drugs is not in practice.

2017 ◽  
Vol 79 (01) ◽  
pp. 096-100 ◽  
Author(s):  
Uwe Mauer ◽  
René Mathieu ◽  
Carsten Hackenbroch ◽  
Janine Knupfer ◽  
Chris Schulz ◽  
...  

AbstractPrimary malignant melanomas of the central nervous system (CNS) are rarely seen entities in the clinical routine. Primary amelanotic melanomas are even rarer. In our literature review, we found only six case reports of primary amelanotic CNS melanomas. Our case report describes the course of a 71-year-old man with a primary amelanotic CNS melanoma with secondary spread to the spine.


2021 ◽  
pp. 157-165
Author(s):  
Hosna Saad Elshony ◽  
Abdelrahman Idris ◽  
Abdulaziz Al-Ghamdi ◽  
Rabia Muddassir

Neuromyelitis optica (NMO) is an autoimmune demyelinating disorder of the central nervous system which is characterized by attacks of optic neuritis and transverse myelitis. An association between NMO and intracerebral hemorrhage (ICH) has been rarely recognized, having been reported only 3 times before. Here we report on a patient with NMO who eventually developed subarachnoid hemorrhage, in order to emphasize that the association between NMO and ICH is mostly not incidental and that the pathological basis for this association should be investigated thoroughly.


2017 ◽  
Vol 12 (1) ◽  
pp. 10-16
Author(s):  
K. A. Komratova ◽  
Yu. G. Abugova ◽  
S. S. Ozerov ◽  
D. S. Abramov ◽  
G. V. Tereshchenko ◽  
...  

2019 ◽  
Vol 39 (6) ◽  
pp. 479-488 ◽  
Author(s):  
Chao He ◽  
Yunxia Wang ◽  
Leyi Zhang ◽  
Chenglong Lu ◽  
Wei Ge ◽  
...  

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