scholarly journals Human Health Consequences of Endocrine-Disrupting Chemicals

2020 ◽  
Author(s):  
Hassan M. Heshmati
Keyword(s):  
Human Health ◽  
Endocrine Disrupting Chemicals ◽  
Economic Consequences ◽  
Future Generations ◽  
Long Term Effects ◽  
Adult Disease ◽  
Endocrine Disrupting ◽  
Global Threat ◽  
Fetus And Neonate

Daily use of chemicals is an essential part of modern life. Endocrine-disrupting chemicals (EDCs) are a heterogeneous group of exogenous chemicals or chemical mixtures that interfere with the action of hormones and consequently cause adverse effects to humans and wildlife. The number of EDCs has markedly increased over the past 60 years. Humans are constantly exposed to hundreds of EDCs mainly through air, water, and food. Exposure to EDCs (in utero or lifetime) may be a significant component of the environmental origin of several medical conditions. The developing fetus and neonate are more sensitive than adults to perturbation by EDCs. The prenatal damage can cause adverse consequences later in life (developmental origins of adult disease). In many cases, the damage is irreversible. There is also a possibility of transgenerational effects. By interfering with hormonal functions, EDCs can contribute to a variety of dysfunctions and diseases including obesity, diabetes, reproductive disorders, and cancers. Information on long-term effects of chronic, low-dose exposure to EDCs is relatively limited. EDCs represent a global threat for human health and cause a high cost for the society. Promoting public knowledge and initiating preventive measures will help minimizing the health and economic consequences of EDCs for future generations.

Explosions and Human Health: The Long-Term Effects of Blast Injury

2012 ◽  
Vol 27 (4) ◽  
pp. 385-391 ◽  
Author(s):  
Sarah E. Finlay ◽  
Michelle Earby ◽  
David J. Baker ◽  
Virginia S.G. Murray
Keyword(s):  
Human Health ◽  
Well Being ◽  
Blast Injury ◽  
Mass Casualties ◽  
Long Term Effects ◽  
Structured Interviews ◽  
National Guidelines ◽  
Emergency Responders ◽  
Response Strategies

AbstractThe immediate patterns of injury from explosions are well documented, from both military and civil experience. However, few studies have focused on less immediately apparent health consequences and latent effects of explosions in survivors, emergency responders and the surrounding community. This review aimed to analyze the risks to health following an explosion in a civil setting.A comprehensive review of the open literature was conducted, and data on 10 relevant military, civilian and industrial events were collected. Events were selected according to availability of published studies and involvement of large numbers of people injured. In addition, structured interviews with experts in the field were conducted, and existing national guidelines reviewed.The review revealed significant and potentially long-term health implications affecting various body systems and psychological well-being following exposure to an explosion. An awareness of the short- and long-term health effects of explosions is essential in screening for blast injuries, and identifying latent pathologies that could otherwise be overlooked in stressful situations with other visually distracting injuries and, often, mass casualties. Such knowledge would guide responsible medical staff in implementing early appropriate interventions to reduce the burden of long-term sequelae. Effective planning and response strategies would ensure accessibility of appropriate health care resources and evidence-based information in the aftermath of an explosion.Finlay SE, Earby M, Baker DJ, Murray VSG. Explosions and human health: the long-term effects of blast injury. Prehosp Disaster Med. 2012;27(4):1-7.

scholarly journals Epidemiological Approaches to the Effects of Endocrine Disrupting Chemicals on Human Health

2000 ◽  
Vol 21 (6) ◽  
pp. 361-367 ◽  
Author(s):  
MASAHARU YAMAMOTO ◽  
HIROTO NAKADAIRA ◽  
KAZUTOSHI NAKAMURA ◽  
KAZUO ENDOH
Keyword(s):  
Human Health ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting

scholarly journals Phenotypical antimicrobial resistance data of clinical and non-clinical Escherichia coli from poultry in Germany between 2014 and 2017

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243772
Author(s):  
Octavio Mesa-Varona ◽  
Heike Kaspar ◽  
Mirjam Grobbel ◽  
Bernd-Alois Tenhagen
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Resistance ◽  
Clinical Isolates ◽  
Long Term Effects ◽  
Time Intervals ◽  
Explanatory Factors ◽  
Global Threat ◽  
Changes Over Time ◽  
Resistance Data

Antimicrobial resistance (AMR) is a global threat in humans and animals, and antimicrobial usage (AMU) has been identified as a main trigger of AMR. The purpose of this work was to compare data on AMR in clinical and non-clinical isolates of Escherichia coli in German broilers and turkeys between 2014 and 2017. Furthermore, we investigated AMR changes over time and the association of changes in AMU with changes in AMR. Data on clinical and non-clinical isolates together with data on therapy frequency of broilers and turkeys were collected from German monitoring systems. Logistic regression analyses were performed to assess the association between the explanatory factors (AMU, year and isolate type) and the dependent variable (AMR). In broilers, the analysis showed lower resistance proportions of clinical isolates of E. coli to ampicillin and colistin (ampicillin: Odds ratio (OR) and 95% confidence interval (CI) = 0.44 (0.3–0.64), p<0.001; colistin: OR and 95% CI = 0.75 (0.73–0.76), p<0.001) but higher proportions for cefotaxime (OR and 95% CI = 4.58 (1.56–15.1), p = 0.007). Resistance to ampicillin, gentamicin and tetracycline was less frequent in clinical isolates in turkeys (ampicillin: OR and 95% CI = 0.4 (0.29–0.53), p<0.001; gentamicin: OR and 95% CI = 0.5 (0.26–0.94), p = 0.035; tetracycline: OR and 95% CI = 0.4 (0.29–0.55), p<0.001). The analysis found decreasing associations of AMU with resistance to tetracycline in turkeys and to colistin in broilers. Year was associated with a decrease in resistance to colistin in broilers and to tetracycline in turkeys. Differences in resistance found in this study between clinical and non-clinical isolates might play an important role in resistance prevalence. This study indicated that further data analyses over longer time intervals are required to clarify the differences found between clinical and non-clinical isolates and to assess the long-term effects of changes in AMU on the prevalence of AMR.

scholarly journals The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome

2021 ◽  
Vol 118 (6) ◽  
pp. e2010217118
Author(s):  
B. Brett Finlay ◽  
Katherine R. Amato ◽  
Meghan Azad ◽  
Martin J. Blaser ◽  
Thomas C. G. Bosch ◽  
...  
Keyword(s):  
Human Health ◽  
Human Microbiome ◽  
Risk Groups ◽  
Hygiene Hypothesis ◽  
Control Measures ◽  
Prevention Measures ◽  
Long Term Effects ◽  
Substantial Impact ◽  
Future Challenges

The COVID-19 pandemic has the potential to affect the human microbiome in infected and uninfected individuals, having a substantial impact on human health over the long term. This pandemic intersects with a decades-long decline in microbial diversity and ancestral microbes due to hygiene, antibiotics, and urban living (the hygiene hypothesis). High-risk groups succumbing to COVID-19 include those with preexisting conditions, such as diabetes and obesity, which are also associated with microbiome abnormalities. Current pandemic control measures and practices will have broad, uneven, and potentially long-term effects for the human microbiome across the planet, given the implementation of physical separation, extensive hygiene, travel barriers, and other measures that influence overall microbial loss and inability for reinoculation. Although much remains uncertain or unknown about the virus and its consequences, implementing pandemic control practices could significantly affect the microbiome. In this Perspective, we explore many facets of COVID-19−induced societal changes and their possible effects on the microbiome, and discuss current and future challenges regarding the interplay between this pandemic and the microbiome. Recent recognition of the microbiome’s influence on human health makes it critical to consider both how the microbiome, shaped by biosocial processes, affects susceptibility to the coronavirus and, conversely, how COVID-19 disease and prevention measures may affect the microbiome. This knowledge may prove key in prevention and treatment, and long-term biological and social outcomes of this pandemic.

Empirical studies of effects of EDC on reproductive physiology (particularly in females)

2001 ◽  
Vol 2001 ◽  
pp. 231-231
Author(s):  
H M Picton
Keyword(s):  
Empirical Studies ◽  
Reproductive Function ◽  
Endocrine Disrupting Compounds ◽  
Female Offspring ◽  
Long Term Effects ◽  
Endocrine Disrupting ◽  
Ovarian Morphology ◽  
Wildlife Populations ◽  
Male Reproductive Health

Over recent years increasing evidence suggests that xeno-oestrogens including alkylphenols, such as nonylphenol and octlyphenol (OP), may represent a threat to the health and reproductive function of humans, domestic animals and wildlife populations. To date most attention has focused on the effect of these endocrine disrupting compounds (EDCs) on male reproductive health. In contrast, hardly any attention has been paid to the potential adverse effects that these compounds may exert in females, where the end points are easier to measure than in males, and where oestrogen modulated diseases such as breast cancer, are of such importance to humans. This is also despite evidence from a number of species, including humans, that exposure in utero to the potent synthetic oestrogen diethylstilbestrol (DES) has profound and long-term effects on ovarian morphology, folliculogenesis, fertility, and pregnancy outcome of female offspring.

Acute physical activity and sports injuries in children

2008 ◽  
Vol 33 (2) ◽  
pp. 393-401 ◽  
Author(s):  
Dorine C.M. Collard ◽  
Evert A.L.M. Verhagen ◽  
Marijke J.M. Chin A Paw ◽  
Willem van Mechelen
Keyword(s):  
Physical Activity ◽  
Sports Injuries ◽  
Controlled Trial ◽  
Economic Consequences ◽  
Long Term Effects ◽  
Injury Mechanisms ◽  
Prevention Model ◽  
Important Challenge ◽  
Short And Long Term

An increase in the physical activity of individuals has many health benefits, but a drawback of an increase in physical activity is the risk of related injuries. To reduce the short- and long-term effects in terms of social and economic consequences, prevention of physical activity injuries is an important challenge. A sequence of prevention model has been proposed that aims to prevent physical activity injuries in different steps. The model includes (i) identification of the problem in terms of incidence and severity of physical activity injuries, (ii) identification of the risk factors and injury mechanisms that play a role in the occurrence of physical activity injuries, (iii) introduction of measures that are likely to reduce the future risk and (or) severity of physical activity injuries, and (iv) evaluation of the effectiveness of the measures by conducting a randomized controlled trial (RCT). This review describes what is currently known about all of the various aspects of the sequence of prevention in children (steps i–iv).

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