scholarly journals Synergic Influence of Parameters Involved in the Polymeric Nanoparticle Preparation on the Efficacy of Photodynamic Therapy

2020 ◽  
Author(s):  
Barbara Silva Figueiredo ◽  
Julyana Noval de Souza Ferreira ◽  
Vannyla Viktória Viana Vasconcelos ◽  
Priscila Ponate de Souza ◽  
Rafaela Vergna De Angeli ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Research Group ◽  
Polymeric Nanoparticles ◽  
Synergic Effect ◽  
Disease Treatment ◽  
Polymeric Nanoparticle ◽  
Nanoparticle Preparation ◽  
Molecule Aggregation

The challenge was always great for lipophilic photosensitizer use in the photodynamic therapy (PDT) for treatment of internal body diseases. Photosensitizer metabolism in liver, incompatibility of the molecules in the gastric acid, aggregation in the bloodstream, opsonization of molecules and phagocyting process hamper the application of the free lipophilic photosensitizer in disease treatment using PDT. This problem has been partially resolved using the drug delivery system to encapsulate the photosensitizer. Many studies have been reported using polymeric nanoparticles to encapsulate the lipophilic photosensitizer showing excellent results for PDT, but few nanoparticulate formulations are available at the pharmacies. The absence of deep knowledge about the influence of synergic effect of parameters used in the nanoparticle preparation on its properties, the photobleaching process of encapsulated photosensitizer and the molecule aggregation into the nanoparticle can decrease the photodynamic efficacy for the lipophilic photosensitizer. Our research group has studied the influence of many parameters on the nanoparticulate properties of several encapsulated phthalocyanines and porphyrin using factorial design, evaluating the free and encapsulated compound aggregation, efficacy to reduce the viability of cancer cells, the photooxidation of the biomolecules and the influence of photobleaching. This work shows the most important results to be consider in the optimization of the polymeric nanoparticle.

Polymeric Nanoparticles for Brain Drug Delivery - A Review

2020 ◽  
Vol 21 (9) ◽  
pp. 649-660
Author(s):  
Subashini Raman ◽  
Syed Mahmood ◽  
Ayah R. Hilles ◽  
Md Noushad Javed ◽  
Motia Azmana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Preparation Methods ◽  
Brain Drug Delivery ◽  
Polymeric Nanoparticle ◽  
Relationship Of ◽  
The Relationship ◽  
The Brain

Background: Blood-brain barrier (BBB) plays a most hindering role in drug delivery to the brain. Recent research comes out with the nanoparticles approach, is continuously working towards improving the delivery to the brain. Currently, polymeric nanoparticle is extensively involved in many therapies for spatial and temporal targeted areas delivery. Methods: We did a non-systematic review, and the literature was searched in Google, Science Direct and PubMed. An overview is provided for the formulation of polymeric nanoparticles using different methods, effect of surface modification on the nanoparticle properties with types of polymeric nanoparticles and preparation methods. An account of different nanomedicine employed with therapeutic agent to cross the BBB alone with biodistribution of the drugs. Results: We found that various types of polymeric nanoparticle systems are available and they prosper in delivering the therapeutic amount of the drug to the targeted area. The effect of physicochemical properties on nanoformulation includes change in their size, shape, elasticity, surface charge and hydrophobicity. Surface modification of polymers or nanocarriers is also vital in the formulation of nanoparticles to enhance targeting efficiency to the brain. Conclusion: More standardized methods for the preparation of nanoparticles and to assess the relationship of surface modification on drug delivery. While the preparation and its output like drug loading, particle size, and charge, permeation is always conflicted, so it requires more attention for the acceptance of nanoparticles for brain delivery.

Poly-(allylamine hydrochloride)-coated but not poly(acrylic acid)-coated upconversion nanoparticles induce autophagy and apoptosis in human blood cancer cells

2015 ◽  
Vol 3 (28) ◽  
pp. 5769-5776 ◽  
Author(s):  
Jiaxiang Juan ◽  
Liang Cheng ◽  
Min Shi ◽  
Zhuang Liu ◽  
Xinliang Mao
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Acrylic Acid ◽  
Cancer Cells ◽  
Human Blood ◽  
Medical Applications ◽  
Upconversion Nanoparticles ◽  
Blood Cancer ◽  
Allylamine Hydrochloride ◽  
Poly Acrylic Acid

Upconversion nanoparticles (UCNPs) have gained increased attention due to their various medical applications such as drug delivery, detection, imaging, and photodynamic therapy.

Targeted photoresponsive TiO2–coumarin nanoconjugate for efficient combination therapy in MDA-MB-231 breast cancer cells: synergic effect of photodynamic therapy (PDT) and anticancer drug chlorambucil

MedChemComm ◽  
2015 ◽  
Vol 6 (5) ◽  
pp. 769-777 ◽  
Author(s):  
Moumita Gangopadhyay ◽  
Sourav K. Mukhopadhyay ◽  
S. Karthik ◽  
Shrabani Barman ◽  
N. D. Pradeep Singh
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Combination Therapy ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Breast Cancer Cells ◽  
Single Component ◽  
Synergic Effect ◽  
Nanoparticle System ◽  
First Time

We have developed for the first time an excellent targeted metallic single component nanoparticle system for combination of PDT and chemotherapy.

scholarly journals Technology Overview and Current Biomedical Application of Polymeric Nanoparticles

2018 ◽  
Vol 8 (6) ◽  
pp. 285-295
Author(s):  
Gurpreet Singh ◽  
Abdul Faruk ◽  
Preet Mohinder Singh Bedi
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Polymeric Nanoparticles ◽  
Preparation Methods ◽  
Polymeric Nanoparticle ◽  
Potential Applications ◽  
Dialysis Method ◽  
Novel Drug ◽  
Current Potential

Polymeric nanoparticle are of great importance in the treatment of various diseases, due to the flexibility in the  modification of their structures. Recent advances in the field of nanotechnology facilitate the engineering of multifunctional polymeric nanoparticles. All the scientific efforts of the pharmaceuticals companies are mainly focusing on two basic aspects, one is to discover new molecules of potential therapeutic interest and second is to develop of a new drug delivery system. In the last few decades,  research and development (R&D) scientists has directed their efforts toward formulating novel drug delivery systems that includes sustained and controlled release, modified release and targeted drug release dosage forms. Application of nanoscience and nanotechnology has opened several new possibilities in development of formulation This review compiles the different preparation methods of polymeric nanoparticles and then briefly explained their current potential applications. Keywords: Polymeric nanoparticles, PLGA, Biomedical applications, Biodegradable, Dialysis method

Curcumin intercalated layered double hydroxide nanohybrid as a potential drug delivery system for effective photodynamic therapy in human breast cancer cells

RSC Advances ◽  
2015 ◽  
Vol 5 (114) ◽  
pp. 93987-93994 ◽  
Author(s):  
Khatereh Khorsandi ◽  
Reza Hosseinzadeh ◽  
Mohsen Fateh
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Potential Drug ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Double Hydroxide

Curcumin intercalated layered double hydroxide nanohybrid as a potential drug delivery system has been used for effective photodynamic therapy (PDT) in human breast cancer cells.

scholarly journals Encapsulation of Essential Oils via Nanoprecipitation Process: Overview, Progress, Challenges and Prospects

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 431 ◽  
Author(s):  
Narimane Lammari ◽  
Ouahida Louaer ◽  
Abdeslam Hassen Meniai ◽  
Abdelhamid Elaissari
Keyword(s):  
Chemical Composition ◽  
Essential Oils ◽  
Water Solubility ◽  
Polymeric Nanoparticles ◽  
Volatile Components ◽  
Effective Protection ◽  
Polymeric Nanoparticle ◽  
Nanoprecipitation Method ◽  
Nanoparticle Preparation ◽  
Targeted Release

Essential oils are of paramount importance in pharmaceutical, cosmetic, agricultural, and food areas thanks to their crucial properties. However, stability and bioactivity determine the effectiveness of essential oils. Polymeric nanoencapsulation is a well-established approach for the preservation of essential oils. It offers a plethora of benefits, including improved water solubility, effective protection against degradation, prevention of volatile components evaporation and controlled and targeted release. Among the several techniques used for the design of polymeric nanoparticles, nanoprecipitation has attracted great attention. This review focuses on the most outstanding contributions of nanotechnology in essential oils encapsulation via nanoprecipitation method. We emphasize the chemical composition of essential oils, the principle of polymeric nanoparticle preparation, the physicochemical properties of essential oils loaded nanoparticles and their current applications.

Surface-modified polymeric nanoparticles for drug delivery to cancer cells

2020 ◽  
Vol 18 (1) ◽  
pp. 1-24
Author(s):  
Arsalan Ahmed ◽  
Shumaila Sarwar ◽  
Yong Hu ◽  
Muhammad Usman Munir ◽  
Muhammad Farrukh Nisar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Polymeric Nanoparticles ◽  
Surface Modified

scholarly journals Polymeric Nanoparticles: Exploring the Current Drug Development and Therapeutic Insight of Breast Cancer Treatment and Recommendations

Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4400
Author(s):  
Ali Sartaj ◽  
Zufika Qamar ◽  
Farheen Fatima Qizilbash ◽  
Annu ◽  
Shadab Md ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Side Effects ◽  
Cancer Treatment ◽  
Polymeric Nanoparticles ◽  
Breast Cancer Treatment ◽  
Chemotherapeutic Agents ◽  
First Line ◽  
Chemotherapy Drugs ◽  
Polymeric Nanoparticle

This manuscript aims to provide the latest update on polymeric nanoparticle drug delivery system for breast cancer treatment after 2015 and how research-oriented it is based on the available research data. Therefore, the authors have chosen breast cancer which is the most frequent and common reason for mortality in women worldwide. The first-line treatment for breast cancer treatment is chemotherapy, apart from surgery, radiation and hormonal therapy. Chemotherapy is associated with lesser therapeutics and undesirable side effects and hence. In addition, drug resistance affects the therapeutic dose to the target site. Although various nano-based formulations have been developed for effective treatment, the polymeric nanoparticles effectively avoid the lacunae of conventional chemotherapy. There has been an effort made to understand the chemotherapy drugs and their conventional formulation-related problems for better targeting and effective drug delivery for breast cancer treatment. Thus, the polymeric nanoparticles as a strategy overcome the associated problems with resulting dose reduction, enhanced bioavailability, reduced side effects, etc. This present review has compiled the research reports published from 2015 to 2021 from different databases, such as PubMed, Google Scholar, ScienceDirect, which are related to breast cancer treatment in which the drug delivery of numerous chemotherapeutic agents alone or in combination, including phytoconstituents formulated into various polymer-based nanoparticles.

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