POLYMERIC NANOPARTICLE MEDIATED TARGETED DRUG DELIVERY TO CANCER CELLS

2014 ◽  
pp. 1-34 ◽  
Author(s):  
Mohd Abdullah
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticle ◽  
Targeted Drug

scholarly journals Aptamer-modified polymer nanoparticles for targeted drug delivery

2016 ◽  
Vol 17 (1-2) ◽  
Author(s):  
Julia Modrejewski ◽  
Johanna-Gabriela Walter ◽  
Imme Kretschmer ◽  
Evren Kemal ◽  
Mark Green ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Mode Of Delivery ◽  
Delivery Systems ◽  
The Body ◽  
Lung Cancer Cells ◽  
Targeted Drug

AbstractThe purpose of this study was to develop a model system for targeted drug delivery. This system should enable targeted drug release at a certain tissue in the body. In conventional drug delivery systems, drugs are often delivered unspecifically resulting in unwarranted adverse effects. To circumvent this problem, there is an increasing demand for the development of intelligent drug delivery systems allowing a tissue-specific mode of delivery. Within this study, nanoparticles consisting of two biocompatible polymers are used. Because of their small size, nanoparticles are well-suited for effective drug delivery. The small size affects their movement through cell and tissue barriers. Their cellular uptake is easier when compared to larger drug delivery systems. Paclitaxel was encapsulated into the nanoparticles as a model drug, and to achieve specific targeting an aptamer directed against lung cancer cells was coupled to the nanoparticles surface. Nanoparticles were characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR), and nanotracking analysis (NTA). Also their surface charge was characterized from ζ-potential measurements. Their preparation was optimized and subsequently specificity of drug-loaded and aptamer-functionalized nanoparticles was investigated using lung cancer cells.

In vitro study of doxorubicin-loaded thermo- and pH-tunable carriers for targeted drug delivery to liver cancer cells

2021 ◽  
Vol 104 ◽  
pp. 93-105
Author(s):  
Sikhumbuzo Charles Kunene ◽  
Kuen-Song Lin ◽  
Meng-Tzu Weng ◽  
Maria Janina Carrera Espinoza ◽  
Chun-Ming Wu
Keyword(s):  
Drug Delivery ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
In Vitro Study ◽  
Vitro Study ◽  
Liver Cancer Cells ◽  
Targeted Drug

Identification of protein targets and the mechanism of the cytotoxic action of Ipomoea turpethum extract loaded nanoparticles against breast cancer cells

2019 ◽  
Vol 7 (39) ◽  
pp. 6048-6063 ◽  
Author(s):  
Mohd Mughees ◽  
Mohd Samim ◽  
Yadhu Sharma ◽  
Saima Wajid
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Breast Cancer Cells ◽  
Cytotoxic Action ◽  
Protein Targets ◽  
Targeted Drug

The shortcomings of the currently available anti-breast cancer agents compel the development of the safer targeted drug delivery for the treatment of breast cancer.

scholarly journals Galactosylated chitosan-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery

2018 ◽  
Vol 5 (12) ◽  
pp. 181027 ◽  
Author(s):  
Wei Liu ◽  
Yongchao Zhu ◽  
Fan Wang ◽  
Xue Li ◽  
Xiaojing Liu ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Loading Capacity ◽  
Colon Cancer Cells ◽  
Functionalized Mesoporous Silica ◽  
Targeted Drug ◽  
Sw620 Cells

Targeted drug delivery to colon cancer cells can significantly enhance the therapeutic efficiency. Herein, we developed 5-fluorouracil (5-FU)-loaded amino-functionalized mesoporous silica nanoparticle (MSN-NH 2 )-based galactosylated chitosans (GCs), which are galactose receptor-mediated materials for colon-specific drug delivery systems. Both unmodified and functionalized nanoparticles were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, nitrogen sorption and dynamic light scattering. Drug loading capacity and drug release properties were determined by ultraviolet spectrophotometry. 5-FU@MSN-NH 2 /GC showed high loading capacity and possessed much higher cytotoxicity on human colon cancer cells (SW620 cells) than 5-FU@MSN-NH 2 and free 5-FU. But, MSN-NH 2 /GC did not show significant cytotoxicity. Subsequently, 5-FU@MSN-NH 2 /GC anti-cancer activity on SW620 cells in vitro was confirmed by cell apoptosis. These results are consistent with the cellular uptake test in which MSN-NH 2 /GC could specifically recognize and bind to cancer cells by the galectin-receptor recognition. But, it is found that pre-addition of galactose in the medium, leading to competitive binding to the galectin receptor of SW620 cells, resulted in a decrease in the binding of MSN-NH 2 /GC to the galectin receptor. The results demonstrated the inorganic–organic nanocomposite could be used as a promising drug delivery carrier for the targeted delivery of drug into galectin-positive colon cancer cells to improve therapeutic index while reducing side effects.

scholarly journals Drug Delivery: Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles (Adv. Mater. 21/2012)

2012 ◽  
Vol 24 (21) ◽  
pp. 2798-2798
Author(s):  
Xinjian Yang ◽  
Xia Liu ◽  
Zhen Liu ◽  
Fang Pu ◽  
Jinsong Ren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Targeted Drug
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