scholarly journals Therapeutic Effect of Glypican-3 Gene Silencing Using siRNA for Ovarian Cancer in a Murine Peritoneal Dissemination Model

2020 ◽  
Author(s):  
Mai Hazekawa ◽  
Takuya Nishinakagawa ◽  
Tomoyo Kawakubo-Yasukochi ◽  
Manabu Nakashima
Keyword(s):  
Ovarian Cancer ◽  
Gene Silencing ◽  
Therapeutic Effect ◽  
Peritoneal Dissemination

scholarly journals Glypican-3 gene silencing for ovarian cancer using siRNA-PLGA hybrid micelles in a murine peritoneal dissemination model

2019 ◽  
Vol 139 (3) ◽  
pp. 231-239 ◽  
Author(s):  
Mai Hazekawa ◽  
Takuya Nishinakagawa ◽  
Tomoyo Kawakubo-Yasukochi ◽  
Manabu Nakashima
Keyword(s):  
Ovarian Cancer ◽  
Gene Silencing ◽  
Peritoneal Dissemination

scholarly journals Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Akira Yokoi ◽  
Yusuke Yoshioka ◽  
Yusuke Yamamoto ◽  
Mitsuya Ishikawa ◽  
Shun-ichi Ikeda ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Extracellular Vesicles ◽  
Peritoneal Dissemination

scholarly journals Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: Implications for therapy

2007 ◽  
Vol 6 (5) ◽  
pp. 795-801 ◽  
Author(s):  
Dineo Khabele ◽  
Deok-Soo Son ◽  
Angelika K. Parl ◽  
Gary L. Goldberg ◽  
Leonard H. Augenlicht ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Growth ◽  
Gene Silencing ◽  
Cancer Cell ◽  
Histone Deacetylases ◽  
Ovarian Cancer Cell ◽  
Class I ◽  
Cancer Cell Growth ◽  
Drug Induced ◽  
Or Gene

scholarly journals Heterotypic CAF-tumor spheroids promote early peritoneal metastasis of ovarian cancer

2019 ◽  
Vol 216 (3) ◽  
pp. 688-703 ◽  
Author(s):  
Qinglei Gao ◽  
Zongyuan Yang ◽  
Sen Xu ◽  
Xiaoting Li ◽  
Xin Yang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Peritoneal Dissemination ◽  
Tumor Stroma ◽  
Stromal Fibroblast ◽  
Low Grade ◽  
Cancer Associated Fibroblasts ◽  
Serous Ovarian Cancer ◽  
Active Involvement ◽  
Essential Components ◽  
Metastatic Capacity

High-grade serous ovarian cancer (HGSOC) is hallmarked by early onset of peritoneal dissemination, which distinguishes it from low-grade serous ovarian cancer (LGSOC). Here, we describe the aggressive nature of HGSOC ascitic tumor cells (ATCs) characterized by integrin α5high (ITGA5high) ATCs, which are prone to forming heterotypic spheroids with fibroblasts. We term these aggregates as metastatic units (MUs) in HGSOC for their advantageous metastatic capacity and active involvement in early peritoneal dissemination. Intriguingly, fibroblasts inside MUs support ATC survival and guide their peritoneal invasion before becoming essential components of the tumor stroma in newly formed metastases. Cancer-associated fibroblasts (CAFs) recruit ITGA5high ATCs to form MUs, which further sustain ATC ITGA5 expression by EGF secretion. Notably, LGSOC is largely devoid of CAFs and the resultant MUs, which might explain its metastatic delay. These findings identify a specialized MU architecture that amplifies the tumor–stroma interaction and promotes transcoelomic metastasis in HGSOC, providing the basis for stromal fibroblast-oriented interventions in hampering OC peritoneal propagation.

scholarly journals Regulation of invasion and peritoneal dissemination of ovarian cancer by mesothelin manipulation

Oncogenesis ◽  
2020 ◽  
Vol 9 (6) ◽  
Author(s):  
Ricardo Coelho ◽  
Sara Ricardo ◽  
Ana Luísa Amaral ◽  
Yen-Lin Huang ◽  
Mariana Nunes ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Peritoneal Dissemination

scholarly journals Withaferin A Synergizes the Therapeutic Effect of Doxorubicin through ROS-Mediated Autophagy in Ovarian Cancer

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e42265 ◽  
Author(s):  
Miranda Y. Fong ◽  
Shunying Jin ◽  
Madhavi Rane ◽  
Raj K. Singh ◽  
Ramesh Gupta ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Therapeutic Effect ◽  
Withaferin A

scholarly journals Combination of KRAS gene silencing and PI3K inhibition for ovarian cancer treatment

2020 ◽  
Vol 318 ◽  
pp. 98-108 ◽  
Author(s):  
Min Ju Kim ◽  
So Jin Lee ◽  
Ju Hee Ryu ◽  
Sun Hwa Kim ◽  
Ick Chan Kwon ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Gene Silencing ◽  
Cancer Treatment ◽  
Kras Gene ◽  
Pi3k Inhibition
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