scholarly journals Current Status, Perspectives, and Future Directions of Multivessel Disease and Left Main Coronary Disease: Its Treatment by PCI or Surgery

2020 ◽  
Author(s):  
Juan Mieres ◽  
Alfredo E. Rodríguez
Keyword(s):  
Coronary Disease ◽  
Multivessel Disease ◽  
Current Status ◽  
Left Main ◽  
Future Directions

The Setting of Coronary Angioplasty in Multivessel Disease: Current Status and Future Directions

1989 ◽  
Vol 7 (4) ◽  
pp. 771-782 ◽  
Author(s):  
Simon H. Stertzer ◽  
Richard E. Shaw ◽  
Richard K. Myler ◽  
Michael J. O'Donnell
Keyword(s):  
Coronary Angioplasty ◽  
Multivessel Disease ◽  
Current Status ◽  
Future Directions

Current Status and Future Directions of Nanoparticulate Strategy for Cancer Immunotherapy

2016 ◽  
Vol 17 (8) ◽  
pp. 755-762 ◽  
Author(s):  
Xu Zhou ◽  
Renhe Liu ◽  
Shuo Qin ◽  
Ruilian Yu ◽  
Yao Fu
Keyword(s):  
Cancer Immunotherapy ◽  
Current Status ◽  
Future Directions

scholarly journals New Approaches for the Treatment of Chronic Graft-Versus-Host Disease: Current Status and Future Directions

2020 ◽  
Vol 11 ◽  
Author(s):  
Nathaniel Edward Bennett Saidu ◽  
Chiara Bonini ◽  
Anne Dickinson ◽  
Magdalena Grce ◽  
Marit Inngjerdingen ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Current Status ◽  
Future Directions ◽  
Host Disease ◽  
Graft Versus Host ◽  
New Approaches

scholarly journals Current Status of Human Papillomavirus-Related Head and Neck Cancer: From Viral Genome to Patient Care

2021 ◽  
Author(s):  
Haoru Dong ◽  
Xinhua Shu ◽  
Qiang Xu ◽  
Chen Zhu ◽  
Andreas M. Kaufmann ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Head And Neck ◽  
Treatment Strategies ◽  
Hpv Infection ◽  
Immune Checkpoint Blockade ◽  
Current Status ◽  
Future Directions ◽  
Sequencing Technologies ◽  
E6 And E7 ◽  
The Continuum

AbstractHuman papillomavirus (HPV) infection identified as a definitive human carcinogen is increasingly being recognized for its role in carcinogenesis of human cancers. Up to 38%–80% of head and neck squamous cell carcinoma (HNSCC) in oropharyngeal location (OPSCC) and nearly all cervical cancers contain the HPV genome which is implicated in causing cancer through its oncoproteins E6 and E7. Given by the biologically distinct HPV-related OPSCC and a more favorable prognosis compared to HPV-negative tumors, clinical trials on de-escalation treatment strategies for these patients have been studied. It is therefore raised the questions for the patient stratification if treatment de-escalation is feasible. Moreover, understanding the crosstalk of HPV-mediated malignancy and immunity with clinical insights from the proportional response rate to immune checkpoint blockade treatments in patients with HNSCC is of importance to substantially improve the treatment efficacy. This review discusses the biology of HPV-related HNSCC as well as successful clinically findings with promising candidates in the pipeline for future directions. With the advent of various sequencing technologies, further biomolecules associated with HPV-related HNSCC progression are currently being identified to be used as potential biomarkers or targets for clinical decisions throughout the continuum of cancer care.

scholarly journals Understanding and assessing flood risk in Vietnam: Current status, persisting gaps, and future directions

2021 ◽  
Author(s):  
Minh Tu Nguyen ◽  
Zita Sebesvari ◽  
Maxime Souvignet ◽  
Felix Bachofer ◽  
Andreas Braun ◽  
...  
Keyword(s):  
Flood Risk ◽  
Current Status ◽  
Future Directions
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