scholarly journals What Is Vibrational Raman Spectroscopy: A Vibrational or an Electronic Spectroscopic Technique or Both?

2020 ◽  
Author(s):  
Søren Hassing
Keyword(s):  
Raman Spectroscopy ◽  
Spectroscopic Technique

scholarly journals In vivo diagnostics of early abiotic plant stress response via Raman spectroscopy

2017 ◽  
Vol 114 (13) ◽  
pp. 3393-3396 ◽  
Author(s):  
Narangerel Altangerel ◽  
Gombojav O. Ariunbold ◽  
Connor Gorman ◽  
Masfer H. Alkahtani ◽  
Eli J. Borrego ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Stress Response ◽  
High Throughput ◽  
Plant Stress ◽  
Spectroscopic Technique ◽  
Plant Phenotyping ◽  
Plant Stress Response ◽  
Concentration Changes ◽  
Concentration Levels

Development of a phenotyping platform capable of noninvasive biochemical sensing could offer researchers, breeders, and producers a tool for precise response detection. In particular, the ability to measure plant stress in vivo responses is becoming increasingly important. In this work, a Raman spectroscopic technique is developed for high-throughput stress phenotyping of plants. We show the early (within 48 h) in vivo detection of plant stress responses. Coleus (Plectranthus scutellarioides) plants were subjected to four common abiotic stress conditions individually: high soil salinity, drought, chilling exposure, and light saturation. Plants were examined poststress induction in vivo, and changes in the concentration levels of the reactive oxygen-scavenging pigments were observed by Raman microscopic and remote spectroscopic systems. The molecular concentration changes were further validated by commonly accepted chemical extraction (destructive) methods. Raman spectroscopy also allows simultaneous interrogation of various pigments in plants. For example, we found a unique negative correlation in concentration levels of anthocyanins and carotenoids, which clearly indicates that plant stress response is fine-tuned to protect against stress-induced damages. This precision spectroscopic technique holds promise for the future development of high-throughput screening for plant phenotyping and the quantification of biologically or commercially relevant molecules, such as antioxidants and pigments.

scholarly journals Raman Spectroscopy for Clinical Oncology

2011 ◽  
Vol 2011 ◽  
pp. 1-20 ◽  
Author(s):  
Michael B. Fenn ◽  
Petros Xanthopoulos ◽  
Georgios Pyrgiotakis ◽  
Stephen R. Grobmyer ◽  
Panos M. Pardalos ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Clinical Oncology ◽  
Causes Of Death ◽  
Spectroscopic Technique ◽  
Special Focus ◽  
Lung Cancers ◽  
Analysis Techniques ◽  
Real World Application ◽  
The World ◽  
Diagnosis Of Cancer

Cancer is one of the leading causes of death throughout the world. Advancements in early and improved diagnosis could help prevent a significant number of these deaths. Raman spectroscopy is a vibrational spectroscopic technique which has received considerable attention recently with regards to applications in clinical oncology. Raman spectroscopy has the potential not only to improve diagnosis of cancer but also to advance the treatment of cancer. A number of studies have investigated Raman spectroscopy for its potential to improve diagnosis and treatment of a wide variety of cancers. In this paper the most recent advances in dispersive Raman spectroscopy, which have demonstrated promising leads to real world application for clinical oncology are reviewed. The application of Raman spectroscopy to breast, brain, skin, cervical, gastrointestinal, oral, and lung cancers is reviewed as well as a special focus on the data analysis techniques, which have been employed in the studies.

In situ Raman spectroscopic technique for high-pressure studies of mineral and fluid inclusions formation 

2021 ◽  
Author(s):  
Nadezda Chertkova ◽  
Anna Spivak ◽  
Egor Zakharchenko ◽  
Yuriy Litvin ◽  
Oleg Safonov ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Diamond Anvil Cell ◽  
High Pressures ◽  
Rapid Development ◽  
Spectroscopic Technique ◽  
Diamond Growth ◽  
Russian Science ◽  
Geological Processes ◽  
Diamond Anvil

<p>Rapid development of <em>in situ</em> experimental techniques provides researchers with new opportunities to model geological processes, which take place deep in the Earth’s interior. Raman spectroscopy is considered a powerful analytical tool for investigation of the samples subjected to high pressures in a diamond anvil cell, since in such experiments phase assemblages can be determined in real time using measured Raman spectra.</p><p>In this study, we describe experimental methods for <em>in situ</em> observation and spectroscopic analysis of fluids and minerals, which constitute environment for diamond growth, at the upper mantle pressure conditions. Experiments were conducted in the externally heated, “piston-cylinder” type diamond anvil cell at pressures exceeding 6 GPa and temperatures up to 600 degree C. Phase relationships and fluid speciation were monitored during experiments to reconstruct the environment and mechanism of inclusions formation. Compared to other analytical tools, commonly used in combination with diamond anvil cell apparatus, Raman spectroscopy offers several advantages, such as short sample preparation time, non-destructive characterization of the phases observed in the sample chamber and relatively short measurement time.</p><p>This work was supported by grant No. 20-77-00079 from the Russian Science Foundation.</p>

Raman Spectroscopy and the Study of Ceramic Manufacture

2016 ◽  
pp. 530-543
Author(s):  
Peter Vandenabeele ◽  
Jolien Van Pevenage
Keyword(s):  
Raman Spectroscopy ◽  
Spectroscopic Technique ◽  
Ceramic Ware ◽  
Weak Effect ◽  
Qualitative Information ◽  
Destructive Analysis ◽  
Ceramic Manufacture ◽  
Non Destructive

This chapter discusses how Raman spectroscopy is used to study ceramic manufactures. Raman spectroscopy is a spectroscopic technique that allows non-destructive analysis, to obtain qualitative information about the investigated samples. It is used to study the mineralogy of the clay bodies and the glassy phases of glazed ceramics. Although the technique is widely known and used, investigation of ceramics with Raman spectroscopy is a challenge due to its weak effect and the heterogeneity of the ceramic ware. Improvements and developments concerning analysis of ceramics with Raman spectroscopy are still possible, for example, in the post-analysis of the obtained Raman data.

scholarly journals Novel Surface-Enhanced Raman Spectroscopy Techniques for DNA, Protein and Drug Detection

Sensors ◽  
2019 ◽  
Vol 19 (7) ◽  
pp. 1712 ◽  
Author(s):  
Chuanpin Chen ◽  
Wenfang Liu ◽  
Sanping Tian ◽  
Tingting Hong
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Spectroscopic Technique ◽  
Machine Learning Techniques ◽  
Drug Detection ◽  
Learning Techniques ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Scattering Signal

Surface-enhanced Raman spectroscopy (SERS) is a vibrational spectroscopic technique in which the Raman scattering signal strength of molecules, absorbed by rough metals or the surface of nanoparticles, experiences an exponential growth (103–106 times and even 1014–1015 times) because of electromagnetic or chemical enhancements. Nowadays, SERS has attracted tremendous attention in the field of analytical chemistry due to its specific advantages, including high selectivity, rich informative spectral properties, nondestructive testing, and the prominent multiplexing capabilities of Raman spectroscopy. In this review, we present the applications of state-of-the-art SERS for the detection of DNA, proteins and drugs. Moreover, we focus on highlighting the merits and mechanisms of achieving enhanced SERS signals for food safety and clinical treatment. The machine learning techniques, combined with SERS detection, are also indicated herein. This review concludes with recommendations for future studies on the development of SERS.

scholarly journals Raman Spectral Analysis for Quality Determination of Grignard Reagent

2020 ◽  
Vol 10 (10) ◽  
pp. 3545
Author(s):  
Rahul Joshi ◽  
Ritu Joshi ◽  
Changyeun Mo ◽  
Mohammad Akbar Faqeerzada ◽  
Hanim Z. Amanah ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Grignard Reagent ◽  
Rapid Determination ◽  
Spectroscopic Method ◽  
Spectroscopic Technique ◽  
Partial Least Square ◽  
Least Square ◽  
Partial Least Square Regression ◽  
Toluene Concentration

Grignard reagent is one of the most popular materials in chemical and pharmaceutical reaction processes, and requires high quality with minimal adulteration. In this study, Raman spectroscopic technique was investigated for the rapid determination of toluene content, which is one of the common adulterants in Grignard reagent. Raman spectroscopy is the most suitable spectroscopic method to mitigate moisture and CO2 interference in the molecules of Grignard reagent. Raman spectra for the mixtures of toluene and Grignard reagent with different concentrations were analyzed with a partial least square regression (PLSR) method. The combination of spectral wavebands in the prediction model was optimized with a variables selection method of variable importance in projection (VIP). The results obtained from the VIP-based PLSR model showed the reliable performance of Raman spectroscopy for predicting the toluene concentration present in Grignard reagent with a correlation coefficient value of 0.97 and a standard error of prediction (SEP) of 0.71%. The results showed that Raman spectroscopy combined with multivariate analysis could be an effective analytical tool for rapid determination of the quality of Grignard reagent.

scholarly journals Subtyping on Live Lymphoma Cell Lines by Raman Spectroscopy

Materials ◽  
2022 ◽  
Vol 15 (2) ◽  
pp. 546
Author(s):  
Klytaimnistra Katsara ◽  
Konstantina Psatha ◽  
George Kenanakis ◽  
Michalis Aivaliotis ◽  
Vassilis M. Papadakis
Keyword(s):  
Raman Spectroscopy ◽  
Quantitative Estimation ◽  
Free Cell ◽  
Spectroscopic Technique ◽  
Lymphoma Cell ◽  
Label Free ◽  
Limited Information ◽  
Non Invasive ◽  
Minimal Sample ◽  
Cell Measurement

Raman spectroscopy is a well-defined spectroscopic technique sensitive to the molecular vibrations of materials, since it provides fingerprint-like information regarding the molecular structure of the analyzed samples. It has been extensively used for non-destructive and label-free cell characterization, particularly in the qualitative and quantitative estimation of amino acids, lipids, nucleic acids, and carbohydrates. Lymphoma cell classification is a crucial task for accurate and prompt lymphoma diagnosis, prognosis, and treatment. Currently, it is mostly based on limited information and requires costly and time-consuming approaches. In this work, we are proposing a fast characterization and differentiation methodology of lymphoma cell subtypes based on Raman spectroscopy. The study was performed in the temperature range of 15–37 °C to identify the best cell measurement conditions. The proposed methodology is fast, accurate, and requires minimal sample preparation, resulting in a potentially promising, non-invasive strategy for early and accurate cell lymphoma characterization.

Quantification of an Active Substance in a Tablet by NIR and Raman Spectroscopy

1998 ◽  
Vol 6 (1) ◽  
pp. 279-289 ◽  
Author(s):  
Ingela Jedvert ◽  
Mats Josefson ◽  
Frans Langkilde
Keyword(s):  
Raman Spectroscopy ◽  
Active Substance ◽  
Reference Method ◽  
Spectroscopic Technique ◽  
Calibration Model ◽  
Baseline Correction ◽  
Spectroscopic Techniques ◽  
Long Term Stability ◽  
Calibration Models

Spectroscopic techniques in combination with chemometrics give opportunities to analyse tablets without time-consuming sample preparation. The aim of the present study was to develop a method to quantify the active substance, isosorbide-5-mononitrate, in Imdur® 120 mg tablets either by NIR diffuse reflectance or Raman spectroscopy. The calibration set was selected to simulate, with the available samples, as closely as possible a full factorial design with three factors. The reference method was liquid chromatography (LC). Calibration models with different baseline correction methods, different parts of wavelength range and different measures of weights have been evaluated. The calibration model found for each spectroscopic technique is discussed. The accuracy for the spectroscopic techniques were equal in merit to the LC method. Both the NIR and the Raman calibrations also showed a good long-term stability. With the baseline correction methods used for the spectra, it was possible to analyse tablets after 1.5 years. In conclusion it is possible to quantify Imdur® 120 mg with either NIR or Raman spectroscopy.

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