scholarly journals Introductory Chapter: Muscular Dystrophy and Recent Therapeutic Strategy

2019 ◽  
Author(s):  
Kunihiro Sakuma
Keyword(s):  
Muscular Dystrophy ◽  
Therapeutic Strategy

scholarly journals Therapeutic Strategy for Heart Failure in Becker Muscular Dystrophy

2016 ◽  
Vol 57 (5) ◽  
pp. 527-529 ◽  
Author(s):  
Koichi Kimura ◽  
Hiroyuki Morita ◽  
Akinori Nakamura ◽  
Katsu Takenaka ◽  
Masao Daimon
Keyword(s):  
Heart Failure ◽  
Muscular Dystrophy ◽  
Therapeutic Strategy ◽  
Becker Muscular Dystrophy

scholarly journals Abnormal Calcium Handling in Duchenne Muscular Dystrophy: Mechanisms and Potential Therapies

2021 ◽  
Vol 12 ◽  
Author(s):  
Satvik Mareedu ◽  
Emily D. Million ◽  
Dongsheng Duan ◽  
Gopal J. Babu
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Therapeutic Strategy ◽  
Muscle Wasting ◽  
Premature Death ◽  
Calcium Handling ◽  
Muscle Degeneration ◽  
Wasting Disease ◽  
Fatty Replacement ◽  
Muscle Wasting Disease

Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disease caused by the loss of dystrophin. DMD is associated with muscle degeneration, necrosis, inflammation, fatty replacement, and fibrosis, resulting in muscle weakness, respiratory and cardiac failure, and premature death. There is no curative treatment. Investigations on disease-causing mechanisms offer an opportunity to identify new therapeutic targets to treat DMD. An abnormal elevation of the intracellular calcium (Cai2+) concentration in the dystrophin-deficient muscle is a major secondary event, which contributes to disease progression in DMD. Emerging studies have suggested that targeting Ca2+-handling proteins and/or mechanisms could be a promising therapeutic strategy for DMD. Here, we provide an updated overview of the mechanistic roles the sarcolemma, sarcoplasmic/endoplasmic reticulum, and mitochondria play in the abnormal and sustained elevation of Cai2+ levels and their involvement in DMD pathogenesis. We also discuss current approaches aimed at restoring Ca2+ homeostasis as potential therapies for DMD.

scholarly journals Errata: Therapeutic Strategy for Heart Failure in Becker Muscular Dystrophy

2016 ◽  
Vol 57 (6) ◽  
pp. 773-773
Author(s):  
Koichi Kimura ◽  
Hiroyuki Morita ◽  
Akinori Nakamura ◽  
Katsu Takenaka ◽  
Masao Daimon
Keyword(s):  
Heart Failure ◽  
Muscular Dystrophy ◽  
Therapeutic Strategy ◽  
Becker Muscular Dystrophy
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