scholarly journals Angiogenesis as a novel therapeutic strategy for Duchenne muscular dystrophy through decreased ischemia and increased satellite cells

2014 ◽  
Vol 5 ◽  
Author(s):  
Yuko Shimizu-Motohashi ◽  
Atsushi Asakura
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Satellite Cells ◽  
Therapeutic Strategy ◽  
Novel Therapeutic

scholarly journals Satellite Cells: Regenerative Mechanisms and Applicability in Muscular Dystrophy

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Gustavo Torres de Souza ◽  
Rafaella de Souza Salomão Zanette ◽  
Danielle Luciana Aurora Soares do Amaral ◽  
Francisco Carlos da Guia ◽  
Claudinéia Pereira Maranduba ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Cell Population ◽  
Satellite Cells ◽  
Specific Pattern ◽  
Cell Populations ◽  
Heterogeneous Cell Population ◽  
Factor Expression ◽  
Transcription Factor Expression ◽  
Severe Tissue

The satellite cells are long regarded as heterogeneous cell population, which is intimately linked to the processes of muscular recovery. The heterogeneous cell population may be classified by specific markers. In spite of the significant amount of variation amongst the satellite cell populations, it seems that their activity is tightly bound to the paired box 7 transcription factor expression, which is, therefore, used as a canonical marker for these cells. Muscular dystrophic diseases, such as Duchenne muscular dystrophy, elicit severe tissue injuries leading those patients to display a very specific pattern of muscular recovery abnormalities. There have been works on the application of precursors cells as a therapeutic alternative for Duchenne muscular dystrophy and initial attempts have proven the cells inefficient; however later endeavours have proposed solutions for the experiments improving significantly the results. The presence of a range of satellite cells populations indicates the existence of specific cells with enhanced capability of muscular recovery in afflicted muscles.

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