scholarly journals Mechanical Force and Actin Dynamics during Cutaneous Squamous Cell Carcinoma (cSCC) Progression: Opportunities for Novel Treatment Modalities

2020 ◽  
Author(s):  
Sarah Boyle ◽  
Zlatko Kopecki
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Mechanical Force ◽  
Actin Dynamics ◽  
Treatment Modalities ◽  
Novel Treatment

scholarly journals Deciphering the Molecular Landscape of Cutaneous Squamous Cell Carcinoma for Better Diagnosis and Treatment

2020 ◽  
Vol 9 (7) ◽  
pp. 2228 ◽  
Author(s):  
Andreea D. Lazar ◽  
Sorina Dinescu ◽  
Marieta Costache
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Light Exposure ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Treatment Development ◽  
Novel Treatment ◽  
Risk Variants ◽  
Molecular Therapies ◽  
Molecular Landscape

Cutaneous squamous cell carcinoma (cSCC) is a common type of neoplasia, representing a terrible burden on patients’ life and clinical management. Although it seldom metastasizes, and most cases can be effectively treated with surgical intervention, once metastatic cSCC displays considerable aggressiveness leading to the death of affected individuals. No consensus has been reached as to which features better characterize the aggressive behavior of cSCC, an achievement hindered by the high mutational burden caused by chronic ultraviolet light exposure. Even though some subtypes have been recognized as high risk variants, depending on certain tumor features, cSCC that are normally thought of as low risk could pose an increased danger to the patients. In light of this, specific genetic and epigenetic markers for cutaneous SCC, which could serve as reliable diagnostic markers and possible targets for novel treatment development, have been searched for. This review aims to give an overview of the mutational landscape of cSCC, pointing out established biomarkers, as well as novel candidates, and future possible molecular therapies for cSCC.

Management of Parotid Metastatic Cutaneous Squamous Cell Carcinoma: Regional Recurrence Rates and Survival

2018 ◽  
Vol 159 (2) ◽  
pp. 293-299 ◽  
Author(s):  
Nir Hirshoren ◽  
Olivia Ruskin ◽  
Lachlan J. McDowell ◽  
Matthew Magarey ◽  
Stephen Kleid ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Adjuvant Radiotherapy ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Regional Recurrence ◽  
Treatment Modalities ◽  
Cancer Center ◽  
Cervical Lymph Nodes

Objectives Extent of parotidectomy and neck dissection for metastatic cutaneous squamous cell carcinoma (cSCC) to the parotid is debated. We describe our experience, analyzing outcomes (overall survival and regional recurrence) associated with surgical extent and adjuvant treatment. Study Design A retrospective cohort study of parotidectomy with or without neck dissection for metastatic cSCC. Setting A tertiary referral cancer center in Australia. Subjects and Methods The study group consisted of patients with metastatic cSCC involving the parotid gland who underwent a curative-intent parotidectomy (superficial or total), with or without neck dissection, between 2003 and 2014. Demographic and clinical data, treatment modalities, and outcome parameters were collected from the electronic institutional database. Results Of 78 patients, 65 underwent superficial parotidectomy. Median follow-up was 6.5 years. Sixty-four patients (82%) patients received adjuvant radiotherapy. Cervical lymph nodes were involved in 6 (24%) elective neck dissections. Involved preauricular, facial, external jugular, and occipital nodes occurred in 36.9%. Adjuvant radiotherapy was associated with improved 5-year survival—50% (95% CI, 36%-69%) versus 20% (95% CI, 6%-70%)—and improved 2-year regional control: 89% (95% CI, 67%-100%) versus 40% (95% CI, 14%-100%). The ipsilateral parotid bed recurrence rate was 3.7% for those who received adjuvant radiotherapy and 27% for those who did not receive radiotherapy. Conclusion This study supports surgery plus adjuvant radiotherapy as a standard of care for metastatic cSCC. The low incidence of parotid bed recurrence with this approach suggests that routine elective deep lobe resection may not be required.

A Case of Anti-TIF1-γ Antibody-positive Dermatomyositis with Cutaneous Squamous Cell Carcinoma

2018 ◽  
Vol 80 (4) ◽  
pp. 331-335
Author(s):  
Reika FUKUCHI ◽  
Sayaka KUWATSUKA ◽  
Yukie SATO ◽  
Yutaka KUWATSUKA ◽  
Atsushi UTANI
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma

Multidisciplinary Expert-Driven Consensus on the Evolving Treatment of Patients with Advanced Cutaneous Squamous Cell Carcinoma

2019 ◽  
Vol 3 ◽  
pp. S50
Author(s):  
Michael R Migden ◽  
Todd E Schlesinger ◽  
Chrysalyne D Schmults ◽  
Scott M Dinehart ◽  
Robert L Ferris ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma

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