scholarly journals Deciphering the Molecular Landscape of Cutaneous Squamous Cell Carcinoma for Better Diagnosis and Treatment

2020 ◽  
Vol 9 (7) ◽  
pp. 2228 ◽  
Author(s):  
Andreea D. Lazar ◽  
Sorina Dinescu ◽  
Marieta Costache
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Light Exposure ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Treatment Development ◽  
Novel Treatment ◽  
Risk Variants ◽  
Molecular Therapies ◽  
Molecular Landscape

Cutaneous squamous cell carcinoma (cSCC) is a common type of neoplasia, representing a terrible burden on patients’ life and clinical management. Although it seldom metastasizes, and most cases can be effectively treated with surgical intervention, once metastatic cSCC displays considerable aggressiveness leading to the death of affected individuals. No consensus has been reached as to which features better characterize the aggressive behavior of cSCC, an achievement hindered by the high mutational burden caused by chronic ultraviolet light exposure. Even though some subtypes have been recognized as high risk variants, depending on certain tumor features, cSCC that are normally thought of as low risk could pose an increased danger to the patients. In light of this, specific genetic and epigenetic markers for cutaneous SCC, which could serve as reliable diagnostic markers and possible targets for novel treatment development, have been searched for. This review aims to give an overview of the mutational landscape of cSCC, pointing out established biomarkers, as well as novel candidates, and future possible molecular therapies for cSCC.

scholarly journals Histopathological Variants of Cutaneous Squamous Cell Carcinoma: A Review

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Valerie R. Yanofsky ◽  
Stephen E. Mercer ◽  
Robert G. Phelps
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Microscopic Analysis ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Malignant Potential ◽  
Histopathological Features ◽  
Risk Variants ◽  
Low Malignant Potential

Nonmelanoma skin cancer (NMSC) is the most common form of cancer in the Caucasian population, with squamous cell carcinoma (SCC) accounting for the majority of NMSC-related metastases and death. While most SCC lesions are indolent tumors with low malignant potential, a wide diversity of SCC subtypes exist, several of which are associated with markedly more aggressive behaviors. Distinguishing these high-risk variants from their counterparts is possible through microscopic analysis, since each subtype possesses unique histopathological features. Early identification of high-risk lesions can allow for more rapid therapeutic intervention, reducing the likelihood of metastasis and death. The authors review specific histopathological features and associated clinical outcomes of the primary subdivisions of SCC.

scholarly journals Publisher Correction: Comparison of two different doses of bleomycin in electrochemotherapy protocols for feline cutaneous squamous cell carcinoma nonsegregated from ultraviolet light exposure

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Denner S. Dos Anjos ◽  
Oscar R. Sierra ◽  
Enrico P. Spugnini ◽  
Andrigo B. De Nardi ◽  
Carlos E. Fonseca-Alves
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Ultraviolet Light ◽  
Squamous Cell ◽  
Light Exposure ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Different Doses

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

scholarly journals Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression

PLoS Genetics ◽  
2021 ◽  
Vol 17 (8) ◽  
pp. e1009094
Author(s):  
Aziz Aiderus ◽  
Justin Y. Newberg ◽  
Liliana Guzman-Rojas ◽  
Ana M. Contreras-Sandoval ◽  
Amanda L. Meshey ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cellular Transformation ◽  
Sleeping Beauty ◽  
Transposon Mutagenesis ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Genetic Landscape ◽  
Molecular Landscape

The systematic identification of genetic events driving cellular transformation and tumor progression in the absence of a highly recurrent oncogenic driver mutation is a challenge in cutaneous oncology. In cutaneous squamous cell carcinoma (cuSCC), the high UV-induced mutational burden poses a hurdle to achieve a complete molecular landscape of this disease. Here, we utilized the Sleeping Beauty transposon mutagenesis system to statistically define drivers of keratinocyte transformation and cuSCC progression in vivo in the absence of UV-IR, and identified both known tumor suppressor genes and novel oncogenic drivers of cuSCC. Functional analysis confirms an oncogenic role for the ZMIZ genes, and tumor suppressive roles for KMT2C, CREBBP and NCOA2, in the initiation or progression of human cuSCC. Taken together, our in vivo screen demonstrates an extremely heterogeneous genetic landscape of cuSCC initiation and progression, which can be harnessed to better understand skin oncogenic etiology and prioritize therapeutic candidates.

Human papillomavirus 16 and p16 positive nasal cutaneous squamous cell carcinoma in immunocompetent men in their twenties

2019 ◽  
Vol 133 (4) ◽  
pp. 348-352
Author(s):  
N Amiraraghi ◽  
R A Scott ◽  
N Balaji ◽  
M M C Yaneza
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Light Exposure ◽  
Case Series ◽  
Disease Process ◽  
Cervical Lymphadenopathy ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Human Papillomavirus 16

AbstractBackgroundCutaneous squamous cell carcinoma is usually associated with long-term ultraviolet light exposure. Human papillomavirus 16 is a high-risk mucosal human papillomavirus type, usually associated with anogenital and oropharyngeal cancer. This paper describes the first two cases of human papillomavirus 16 and p16 related nasal cutaneous squamous cell carcinoma.MethodProspective case series from December 2015.ResultsTwo young, male, fair-skinned patients had large (greater than 20 mm), rapidly growing, ulcerated lesions of the nasal tip. The tumours were excised, with at least a 6 mm margin, and the patients' noses were subsequently reconstructed. Neither patient had cervical lymphadenopathy or underwent adjuvant radiotherapy. Both patients were registered at the same general practice. The tumours were human papillomavirus 16 and p16 positive; the latter indicated that the virus was driving the disease process. Except for superficial burns, neither patient had other risk factors.ConclusionChanges in sexual practices have led to an increase in human papillomavirus positive oropharyngeal carcinoma and there may be an associated increase in human papillomavirus type 16 positive nasal cutaneous squamous cell carcinoma.

scholarly journals Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression

2019 ◽  
Author(s):  
Aziz Aiderus ◽  
Justin Y. Newberg ◽  
Liliana Guzman-Rojas ◽  
Ana M. Contreras-Sandoval ◽  
Amanda L. Meshey ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cellular Transformation ◽  
Sleeping Beauty ◽  
Transposon Mutagenesis ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Genetic Landscape ◽  
Molecular Landscape

AbstractThe systematic identification of genetic events driving cellular transformation and tumor progression in the absence of a highly recurrent oncogenic driver mutation is a challenge in cutaneous oncology. In cutaneous squamous cell carcinoma (cuSCC), the high UV-induced mutational burden poses a hurdle to achieve a complete molecular landscape of this disease. Here, we utilized the Sleeping Beauty transposon mutagenesis system to statistically define drivers of keratinocyte transformation and cuSCC progression in vivo in the absence of UV-IR, and identified both known tumor suppressor genes and novel oncogenic drivers of cuSCC. Functional analysis confirms an oncogenic role for the ZMIZ genes, and tumor suppressive roles for KMT2C, CREBBP and NCOA2, in the initiation or progression of human cuSCC. Taken together, our in vivo screen demonstrates an extremely heterogeneous genetic landscape of cuSCC initiation and progression, which can be harnessed to better understand skin oncogenic etiology and prioritize therapeutic candidates.

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