scholarly journals Polymeric Nanoparticles Engineered as a Vaccine Adjuvant-Delivery System

2018 ◽  
Author(s):  
Bin Liu ◽  
Zhangbao Wu ◽  
Ting Liu ◽  
Rui Qian ◽  
Tingni Wu ◽  
...  
Keyword(s):  
Delivery System ◽  
Polymeric Nanoparticles ◽  
Vaccine Adjuvant

Design of 99mTc radiolabeled gemcitabine polymeric nanoparticles as drug delivery system and in vivo evaluation

2021 ◽  
Vol 263 ◽  
pp. 124380
Author(s):  
Çiğdem İçhedef ◽  
Serap Teksöz ◽  
Oğuz Çetin ◽  
Burcu Aydın ◽  
İbrahim Sarıkavak ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymeric Nanoparticles ◽  
In Vivo Evaluation

scholarly journals Fabrication of PLA-PEG Nanoparticles as Delivery Systems for Improved Stability and Controlled Release of Catechin

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Neha Atulkumar Singh ◽  
Abul Kalam Azad Mandal ◽  
Zaved Ahmed Khan
Keyword(s):  
Controlled Release ◽  
Delivery System ◽  
Oral Delivery ◽  
Polymeric Nanoparticles ◽  
Double Emulsion ◽  
Hydrodynamic Diameter ◽  
Sem Image ◽  
Oral Delivery System ◽  
Improved Stability

The purpose of this study was to develop an oral delivery system for the controlled release of catechin and evaluate the antioxidant potential and stability of catechin loaded PLA/PEG nanoparticles (CATNP). Nanoparticles were synthesized using a double emulsion solvent evaporation method. The fabricated nanoparticles were relatively small with a hydrodynamic diameter of 300 nm and an encapsulation efficiency of 95%. SEM image analysis showed uniform sized and spherically shaped nanoparticles. In vitro release profiles indicated a slow and sustained release of catechin from the nanoparticle. Stability of the nanoparticle in simulated gastric and intestinal fluids is maintained due to the PEG coating on the nanoparticles, which effectively protected catechin against gastrointestinal enzyme activity. Enhanced inhibition action of free radicals and metal chelation potential was noted when catechin was encapsulated in these polymeric nanoparticles. The reports obtained from this study would provide an opportunity for designing an oral delivery system aimed at inhibiting oxidative stress in the human body.

Development of an Insulin Nano-Delivery System through Buccal Administration

2022 ◽  
Vol 19 ◽  
Author(s):  
Diaa Al-Domi ◽  
Ayat Bozeya ◽  
Mohamed Al-Fandi
Keyword(s):  
Insulin Release ◽  
Delivery System ◽  
Polymeric Nanoparticles ◽  
Sustained Delivery ◽  
Atomic Force ◽  
Oil In Water ◽  
In Vitro Investigation ◽  
Coating Method ◽  
Evaporation Technique

Aim: To develop a new nano-delivery system for insulin buccal administration. Background: Biodegradable polymeric nanoparticles (PNPs) had viewed countless breakthroughs in drug delivery systems. The main objective of PNPs application in delivering and carrying different promising drugs is to make sure that the drugs being delivered to their action sites. As a result maximizing the desired effect and overcoming their limitations and drawbacks. Objectives: The main goals of this study were to produce an insulin consumable nano-delivery system for buccal administration and enhance the mucoadhesive effect in sustaining insulin release. Methods: Water in oil in water (W-O-W) microemulsion solvent evaporation technique was used for the preparation of nanoparticles consisting from positively charged poly (D, L-lactide-co-glycolide) coated with chitosan and loaded with insulin. Later, a consumable buccal film was prepared by the spin coating method and loaded with the previously prepared nanoparticles. Results: The newly prepared nanoparticle was assessed in terms of size, charge and surface morphology using a Scanning Electron Microscope (SEM), zeta potential, Atomic Force Microscope (AFM), and Fourier Transform Infra-red (FTIR) spectroscopy. An in-vitro investigation of the insulin release, from nanoparticles and buccal film, demonstrated controlled as well as sustained delivery over 6 hrs. The cumulative insulin release decreased to about (28.9%) with buccal film in comparing with the nanoparticle (50 %). Conclusion: The buccal film added another barrier for insulin release. Therefore, the release was sustained.

Archaeal lipid mucosal vaccine adjuvant and delivery system

2010 ◽  
Vol 9 (4) ◽  
pp. 431-440 ◽  
Author(s):  
Girishchandra B Patel ◽  
Wangxue Chen
Keyword(s):  
Delivery System ◽  
Mucosal Vaccine ◽  
Vaccine Adjuvant

scholarly journals Quality by Design: A Methodical Approach in Development of Nano Delivery System

2021 ◽  
Vol 69 (2) ◽  
Author(s):  
Priya S. Milmile ◽  
Rasika J. Patil ◽  
Samiksha M ◽  
Kamlesh J. Wadher ◽  
Milind J. Umekar
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Quality By Design ◽  
Polymeric Nanoparticles ◽  
Pharmaceutical Product ◽  
Manufacture Process ◽  
Methodical Approach ◽  
Quality Profile ◽  
Nano Drug Delivery ◽  
And Control

Pharmaceutical quality by design (QbD) is a methodical approach to development of drug which begins with predefined objectives and control based on scientific acumen and quality risk management. QbD in the field of pharmacy is based on the basic understanding of the quality profile of final products affects by materials and process parameters. The application of QbD in designing of drug delivery system is based on a sound understanding of the sources of variability and the manufacture process and parameters. Most of problems in quality in formulations are related to the way designing of pharmaceutical product was carried out. The most important element of QbD based drug delivery development is the risk assessment (RA) activity which is important aspect during the development process. This review article addressed various concepts and applications od QbD to optimize and develop various nano drug delivery systems such as, examples liposomes, proliposome, nanoliposomes, polymeric nanoparticles, microsponges, solid lipid nanoparticles, transgel. nanostructured lipid carriers, nano emulsions with the research published in recent years.

scholarly journals ENHANCING OF ORAL BIOAVAILABILITY OF POORLY WATER-SOLUBLE ANTIHYPERTENSIVE DRUGS

2021 ◽  
pp. 42-47
Author(s):  
BITOPAN BAISHYA ◽  
SHEIKH SOFIUR RAHMAN ◽  
DAMANBHALANG RYNJAH ◽  
KAMALLOCHAN BARMAN ◽  
SARANGA SHEKHAR BORDOLOI ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Patient Compliance ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Antihypertensive Drugs ◽  
Polymeric Nanoparticles ◽  
Delivery Systems ◽  
Water Soluble ◽  
Oral Drug

Among various routes of drug delivery, Oral administration is the most convenient route because of its high patient compliance. Although oral drug delivery is effective for drugs with high aqueous solubility and epithelial permeability; however for poorly aqueous soluble drug the membrane permeability, chemical, and enzymatic stability of drugs are the major limitations in successful oral drug delivery. Almost 70% of the new drug candidates which shows poor bioavailability, the antihypertensive drugs are among those. Novel drug delivery systems are available in many areas to overcome the problems associated with hydrophobic drugs and the nanotechnology-based drug delivery system is the most potential to beat the challenges related to the oral route of administration with some important advantages such as the colloidal size, biocompatibility, lowered dose size, reduced toxicity, patient compliance and drug targeting. The foremost common nanotechnology-based strategies utilized in the development of delivery systems are nano-emulsions, nano-suspensions, dendrimers, micelles, liposomes, solid lipid nanoparticles, polymeric nanoparticles, carbon nanotubes, Self-Nano-emulsifying Drug Delivery System, proliposomes, nano-crystals, and so forth, which give controlled, sustained, and targeted drug delivery. The appliance of those systems within the treatment of hypertension continues to broaden. This review focuses on various nano-carriers available in oral drug administration for improving solubility profile, dissolution, and consequently bioavailability of hydrophobic antihypertensive drugs.

scholarly journals Liposomes Used as a Vaccine Adjuvant-Delivery System

Liposomes ◽  
2017 ◽  
Author(s):  
Ning Wang ◽  
Tingni Wu ◽  
Ting Wang
Keyword(s):  
Delivery System ◽  
Vaccine Adjuvant
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