scholarly journals Liposomes Used as a Vaccine Adjuvant-Delivery System

Liposomes ◽  
2017 ◽  
Author(s):  
Ning Wang ◽  
Tingni Wu ◽  
Ting Wang
Keyword(s):  
Delivery System ◽  
Vaccine Adjuvant

Archaeal lipid mucosal vaccine adjuvant and delivery system

2010 ◽  
Vol 9 (4) ◽  
pp. 431-440 ◽  
Author(s):  
Girishchandra B Patel ◽  
Wangxue Chen
Keyword(s):  
Delivery System ◽  
Mucosal Vaccine ◽  
Vaccine Adjuvant

scholarly journals Chitosan Plus Compound 48/80: Formulation and Preliminary Evaluation as a Hepatitis B Vaccine Adjuvant

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 72 ◽  
Author(s):  
Dulce Bento ◽  
Sandra Jesus ◽  
Filipa Lebre ◽  
Teresa Gonçalves ◽  
Olga Borges
Keyword(s):  
Mast Cell ◽  
Hepatitis B ◽  
Delivery System ◽  
Hepatitis B Surface Antigen ◽  
Chitosan Nanoparticles ◽  
Vaccine Adjuvant ◽  
Preliminary Evaluation ◽  
Vaccine Adjuvants ◽  
Cell Activator ◽  
Mast Cell Activator

Current vaccine research is mostly based on subunit antigens. Despite the better toxicity profile of these antigens they are often poorly immunogenic, so adjuvant association has been explored as a strategy to obtain a potent vaccine formulation. Recently, mast cell activators were recognized as a new class of vaccine adjuvants capable of potentiating mucosal and systemic immune responses. In this study, a co-adjuvanted delivery system was developed and characterized, combining the mast cell activator C48/80 with chitosan nanoparticles (Chi-C48/80 NPs), and the results were compared with plain chitosan nanoparticles. The adsorption of model antigens onto the NP surface as well as the biocompatibility of the system was not affected by the incorporation of C48/80 in the formulation. The stability of the nanoparticles was demonstrated by studying the variation of size and zeta potential at different times, and the ability to be internalized by antigen presenting cells was confirmed by confocal microscopy. Vaccination studies with hepatitis B surface antigen loaded Chi-C48/80 NPs validated the adjuvanticity of the delivery system, demonstrating for the first time a successful association between a mast cell activator and chitosan nanoparticles as a vaccine adjuvant for hepatitis B virus, applied to a nasal vaccination strategy.

Microneedle arrays fabricated with the aluminum-based cochleates as an effective vaginal vaccine adjuvant-delivery system (VADS)

2018 ◽  
Vol 14 (5) ◽  
pp. 1745
Author(s):  
Ning Wang ◽  
Xueting Wang ◽  
Yuanyuan Zhen ◽  
Ning Li ◽  
Shaohong Jiang ◽  
...  
Keyword(s):  
Delivery System ◽  
Vaccine Adjuvant ◽  
Microneedle Arrays
Sign in / Sign up

Export Citation Format

Share Document