scholarly journals Preventing Erectile Dysfunction after Radical Prostatectomy: Nerve-Sparing Techniques, Penile Rehabilitation, and Novel Regenerative Therapies

Prostatectomy ◽  
2019 ◽  
Author(s):  
Michael Whalen
Keyword(s):  
Erectile Dysfunction ◽  
Radical Prostatectomy ◽  
Nerve Sparing ◽  
Regenerative Therapies ◽  
Penile Rehabilitation

scholarly journals Penile Rehabilitation and Treatment Options for Erectile Dysfunction Following Radical Prostatectomy and Radiotherapy: A Systematic Review

2021 ◽  
Vol 8 ◽  
Author(s):  
Melianthe Nicolai ◽  
Ahmet Urkmez ◽  
Selcuk Sarikaya ◽  
Mikkel Fode ◽  
Marco Falcone ◽  
...  
Keyword(s):  
Systematic Review ◽  
Erectile Dysfunction ◽  
Radical Prostatectomy ◽  
Animal Studies ◽  
Structural Changes ◽  
Treatment Options ◽  
Nerve Sparing ◽  
Phosphodiesterase Type 5 Inhibitors ◽  
Pelvic Floor Training ◽  
Penile Rehabilitation

After radical prostatectomy (RP) or radiotherapy (RT) for prostate cancer, erectile dysfunction (ED) is the main complication next to urinary incontinence, affecting quality of life. The pathophysiology of ED after these treatments is believed to include neuropraxia causing reduced oxygenation and structural changes of the tissue in the corpora cavernosa. Next to the option of sparing the nerves during RP, research has been focusing on methods for penile rehabilitation after RP and RT, since it occurs often, even after nerve-sparing techniques were used. In animal studies, the use of phosphodiesterase type 5 inhibitors (PDE5i) after cavernous nerve damage is supported, but results in human studies are contradictory. Non-medical treatment options such as vacuum device therapy, hyperbaric oxygen therapy, yoga, aerobic, or pelvic floor training may be helpful, but evidence is scarce. Clear guidelines for penile rehabilitation are not yet available. However, care and support for ED after RP and RT is highly demanded by a large group of patients, so measures have to be taken even though the evidence is not strong yet. In this systematic review, an overview of the literature for penile rehabilitation and treatment options for ED after RP and RT is provided, using only randomized controlled trials (RCT).

scholarly journals Preclinical Evidence for the Benefits of Penile Rehabilitation Therapy following Nerve-Sparing Radical Prostatectomy

2008 ◽  
Vol 2008 ◽  
pp. 1-10 ◽  
Author(s):  
M. Albersen ◽  
S. Joniau ◽  
H. Claes ◽  
H. Van Poppel
Keyword(s):  
Erectile Dysfunction ◽  
Radical Prostatectomy ◽  
Erectile Function ◽  
Nerve Fibers ◽  
Nerve Sparing ◽  
Pde5 Inhibitors ◽  
Rehabilitation Therapy ◽  
Erectile Tissue ◽  
Vasoactive Substances ◽  
Penile Rehabilitation

Erectile dysfunction following radical prostatectomy remains a frequent problem despite the development of nerve-sparing techniques. This erectile dysfunction is believed to be neurogenic, enhanced by hypoxia-induced structural changes which result in additional veno-occlusive dysfunction. Recently, daily use of intracavernous vasoactive substances and oral use of PDE5-inhibitors have been clinically studied for treatment of postprostatectomy erectile dysfunction. Since these studies showed benefits of “penile rehabilitation therapy,” these effects have been studied in a preclinical setting. We reviewed experimental literature on erectile tissue preserving and neuroregenerative treatment strategies, and found that preservation of the erectile tissue by the use of intracavernous nitric oxide donors or vasoactive substances, oral PDE5-inhibitors, and hyperbaric oxygen therapy improved erectile function by antifibrotic effects and preservation of smooth muscle. Furthermore, neuroregenerative strategies using neuroimmunophilin ligands, neurotrophins, growth factors, and stem cell therapy show improved erectile function by preservation of NOS-containing nerve fibers.

Inhibition of Interleukin‐6 Attenuates Erectile Dysfunction in a Rat Model of Nerve-Sparing Radical Prostatectomy

2011 ◽  
Vol 8 (7) ◽  
pp. 1957-1964 ◽  
Author(s):  
Shinichi Yamashita ◽  
Ryuichi Kato ◽  
Ko Kobayashi ◽  
Shin‐ichi Hisasue ◽  
Yoichi Arai ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Radical Prostatectomy ◽  
Rat Model ◽  
Interleukin 6 ◽  
Nerve Sparing

Relation between Erectile Dysfunction and Urinary Incontinence after Nerve-Sparing and Non-Nerve-Sparing Radical Prostatectomy

2004 ◽  
Vol 73 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Akira Tsujimura ◽  
Kiyomi Matsumiya ◽  
Yasushi Miyagawa ◽  
Natsuki Takaha ◽  
Kazuo Nishimura ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Erectile Dysfunction ◽  
Radical Prostatectomy ◽  
Nerve Sparing

Persistent Erectile Dysfunction Following Radical Prostatectomy: The Association between Nerve-Sparing Status and the Prevalence and Chronology of Venous Leak

2009 ◽  
Vol 6 (10) ◽  
pp. 2813-2819 ◽  
Author(s):  
Raanan Tal ◽  
Rolando Valenzuela ◽  
Nadid Aviv ◽  
Marilyn Parker ◽  
W. Bedford Waters ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Radical Prostatectomy ◽  
Nerve Sparing

Rationale for early penile rehabilitation following nerve-sparing radical prostatectomy

2007 ◽  
Vol 4 (3) ◽  
pp. 101-106
Author(s):  
Rupesh Raina ◽  
Geetu Pahlajani ◽  
Craig D. Zippe ◽  
Ashok Agarwal
Keyword(s):  
Radical Prostatectomy ◽  
Nerve Sparing ◽  
Penile Rehabilitation
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