scholarly journals Role of Flavonoids as Wound Healing Agent

2018 ◽  
Author(s):  
Muhammad Shahzad Aslam ◽  
Muhammad Syarhabil Ahmad ◽  
Humayun Riaz ◽  
Syed Atif Raza ◽  
Shahzad Hussain ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Agent

scholarly journals THE POTENTIAL ROLE OF GENUS TINOSPORA IN WOUND HEALING: A REVIEW

2021 ◽  
pp. 21-29
Author(s):  
MICHELE FERNANDEZ ◽  
NAVEEN KUMAR SHIVASHEKAREGOWDA ◽  
YOW HUI YIN
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Future Research ◽  
Wound Healing Process ◽  
Digestive Disorder ◽  
Healing Agent ◽  
Phytochemical Constituents ◽  
Underlying Mechanisms ◽  
Ethnomedicinal Uses

Genus Tinospora has been used in traditional medicine throughout various parts of Asia, particularly in India, China, Thailand, Malaysia and Cambodia. Its ethnomedicinal uses include treatment for fever, cold, oral ulcer, headaches, diarrhoea, diabetes, digestive disorder and rheumatoid arthritis. Some of its ethnomedicinal uses have been justified via scientific studies, include antidiabetic, antioxidant, anti-inflammatory and antimicrobial effects. Recently, several studies have been initiated to investigate the role of Tinospora species in wound healing. This comprehensive review used updated information obtained from systematic literature search using PubMed, Scopus, Science Direct and Google Scholar, to assess the wound healing properties of eleven major Tinospora species namely, T. cordifolia, T. crispa, T. sagittata, T. sinensis, T. bakis, T. craveniana, T. tuberculata, T. capillipes, T. rumphii, T. smilacina, and T. baenzigeri. The information obtained revealed that only T. cordifolia and T. crispa have been reported on its wound-healing abilities. Studies demonstrated that T. cordifolia is associated with early re-epithelisation, enhanced tensile strength, increased granulation tissues and increased collagen contents. Whereas T. crispa is reported with wound healing activity through the elevated antioxidant enzymes and inflammation phase. Nevertheless, there is limited evidence on phytochemical constituents from plant extracts that contribute to the wound healing process and their underlying mechanisms. This review deduced the potential gaps for future research aiming to study the genus Tinospora as a potential wound healing agent.

scholarly journals Honey: A Potential Therapeutic Agent for Managing Diabetic Wounds

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Fahmida Alam ◽  
Md. Asiful Islam ◽  
Siew Hua Gan ◽  
Md. Ibrahim Khalil
Keyword(s):  
Wound Healing ◽  
Clinical Effectiveness ◽  
Diabetic Wound ◽  
Healing Agent ◽  
Diabetic Wound Healing ◽  
Effective Choice ◽  
Ancient Times ◽  
Diabetic Wounds ◽  
Topical Medications

Diabetic wounds are unlike typical wounds in that they are slower to heal, making treatment with conventional topical medications an uphill process. Among several different alternative therapies, honey is an effective choice because it provides comparatively rapid wound healing. Although honey has been used as an alternative medicine for wound healing since ancient times, the application of honey to diabetic wounds has only recently been revived. Because honey has some unique natural features as a wound healer, it works even more effectively on diabetic wounds than on normal wounds. In addition, honey is known as an “all in one” remedy for diabetic wound healing because it can combat many microorganisms that are involved in the wound process and because it possesses antioxidant activity and controls inflammation. In this review, the potential role of honey’s antibacterial activity on diabetic wound-related microorganisms and honey’s clinical effectiveness in treating diabetic wounds based on the most recent studies is described. Additionally, ways in which honey can be used as a safer, faster, and effective healing agent for diabetic wounds in comparison with other synthetic medications in terms of microbial resistance and treatment costs are also described to support its traditional claims.

Experience of negative pressure wound therapy over sternal wound healing: A retrospective review

WCET Journal ◽  
2019 ◽  
Vol 39 (2) ◽  
pp. 9-18
Author(s):  
Wai Sze Ho ◽  
Wai Kuen Lee ◽  
Ka Kay Chan ◽  
Choi Ching Fong
Keyword(s):  
Wound Healing ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Assessment Tool ◽  
Wound Care ◽  
Wound Therapy ◽  
Treatment Pathways ◽  
Wound Assessment ◽  
One Year

Objectives The aim of this study was to retrospectively review the effectiveness of negative pressure wound therapy (NPWT) in sternal wound healing with the use of the validated Bates-Jensen Wound Assessment Tool (BWAT), and explore the role of NPWT over sternal wounds and future treatment pathways. Methods Data was gathered from patients' medical records and the institution's database clinical management system. Seventeen subjects, who had undergone cardiothoracic surgeries and subsequently consulted the wound care team in one year were reviewed. Fourteen of them were included in the analysis. Healing improvement of each sternal wound under continuous NPWT and continuous conventional dressings was studied. In total, 23 continuous NPWT and 13 conventional dressing episodes were analysed with the BWAT. Results Among conventional dressing episodes, sternal wound improvement was 2.5–3% over 10 days to 3.5 weeks, whereas 4–5% sternal healing was achieved in 5 days to 2 weeks with sternal wire presence. Better healing at 11% in 1 week by conventional dressing was attained after sternal wire removal. In NPWT episodes, 8–29%, 13–24%, and 15–46% of healing was observed in 2 weeks, 3.5 to 5 weeks and 6 to 7 weeks, respectively. Only 39% wound healing was acquired at the 13th week of NPWT in one subject. With sternal wire present, 6%–29% wound healing progress was achieved by NPWT in 1–4 weeks, and 16–23% wound improvement in 2 to 4.5 weeks by NWPT after further surgical debridement. After sternal wire removal, 6–34% sternal wound healing occurred by continuous NPWT for 1–2 weeks, and maximum healing at 46% after 2.5 weeks of NPWT were observed. Conclusions Better wound healing was achieved in the NPWT group in comparison to conventional dressings alone. However, suboptimal sternal wound healing by NPWT alone was observed. Removal of sternal wire may improve the effectiveness of NPWT. Successful tertiary closure after NPWT among subjects supports the important bridging role of NPWT in sternal wound healing. Factors causing stagnant sternal wound healing by NPWT alone are discussed.

The role of angiopoetic factors in wound healing among patients with diabetes treated with negative-pressure wound therapy

Leczenie Ran ◽  
2015 ◽  
Vol 11 (4) ◽  
pp. 171-178
Author(s):  
Beata Mrozikiewicz-Rakowska ◽  
Joanna Kania ◽  
Ewelina Bucior ◽  
Adriana Nowak ◽  
Tomasz Grzela ◽  
...  
Keyword(s):  
Wound Healing ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Wound Therapy ◽  
Patients With Diabetes

Role of iron in wound healing

Leczenie Ran ◽  
2013 ◽  
Vol 10 (2) ◽  
pp. 41-45
Author(s):  
Ewa Rojczyk-Gołębiewska ◽  
Marek Kucharzewski ◽  
Katarzyna Wilemska-Kucharzewska ◽  
Artur Pałasz
Keyword(s):  
Wound Healing

Role of topical insulin therapy as an adjunct in the management of pressure ulcer

2020 ◽  
Vol 2 (3) ◽  
pp. 01-03
Author(s):  
Ravi Chittoria
Keyword(s):  
Wound Healing ◽  
Insulin Therapy ◽  
Pressure Ulcer ◽  
Healing Rate ◽  
Pressure Sore ◽  
Pressure Sores ◽  
Established Method ◽  
Wound Bed Preparation ◽  
Wound Healing Rate

Pressure ulcer or pressure sore is one of the complications seen in bedridden patients. Management of these ulcers is often challenging. But there is no well-established method that accelerates the wound healing rate. Various adjunctive methods are used for wound bed preparation before definitive reconstruction plan is made. Here we describe our experience in the role of insulin therapy as an adjunct in the management of pressure sores.

Inhibitory Role of Plasminogen Activator Inhibitor-1 in Arterial Wound Healing and Neointima Formation

Circulation ◽  
1997 ◽  
Vol 96 (9) ◽  
pp. 3180-3191 ◽  
Author(s):  
Peter Carmeliet ◽  
Lieve Moons ◽  
Roger Lijnen ◽  
Stefaan Janssens ◽  
Florea Lupu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Neointima Formation ◽  
Plasminogen Activator Inhibitor 1 ◽  
Inhibitory Role ◽  
Activator Inhibitor

scholarly journals Infarct in the Heart: What’s MMP-9 Got to Do with It?

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 491
Author(s):  
Mediha Becirovic-Agic ◽  
Upendra Chalise ◽  
Michael J. Daseke ◽  
Shelby Konfrst ◽  
Jeffrey D. Salomon ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cardiac Repair ◽  
Dual Effect ◽  
Strong Connection ◽  
The Past ◽  
Left Ventricle Remodeling ◽  
Inflammation Resolution ◽  
Metalloproteinase 9 ◽  
Cell Transition

Over the past three decades, numerous studies have shown a strong connection between matrix metalloproteinase 9 (MMP-9) levels and myocardial infarction (MI) mortality and left ventricle remodeling and dysfunction. Despite this fact, clinical trials using MMP-9 inhibitors have been disappointing. This review focuses on the roles of MMP-9 in MI wound healing. Infiltrating leukocytes, cardiomyocytes, fibroblasts, and endothelial cells secrete MMP-9 during all phases of cardiac repair. MMP-9 both exacerbates the inflammatory response and aids in inflammation resolution by stimulating the pro-inflammatory to reparative cell transition. In addition, MMP-9 has a dual effect on neovascularization and prevents an overly stiff scar. Here, we review the complex role of MMP-9 in cardiac wound healing, and highlight the importance of targeting MMP-9 only for its detrimental actions. Therefore, delineating signaling pathways downstream of MMP-9 is critical.

Sign in / Sign up

Export Citation Format

Share Document