scholarly journals Endocrine Disruptors and Reproductive Health in Males

2018 ◽  
Author(s):  
Tomas Jambor ◽  
Hana Greifova ◽  
Jana Bistakova ◽  
Norbert Lukac
Keyword(s):  
Reproductive Health ◽  
Endocrine Disruptors

scholarly journals Pesticides as endocrine distruptors of the reproductive system (literature review and own research)

2021 ◽  
pp. 49-62
Author(s):  
Ninel Shepelska ◽  
Mykola Prodanchuk ◽  
Yana Kolianchuk
Keyword(s):  
Reproductive Health ◽  
Endocrine Disruptors ◽  
Reproductive System ◽  
Reproductive Toxicity ◽  
Endocrine System ◽  
Reproductive Function ◽  
Dose Dependence ◽  
Animal Cells ◽  
Wide Range ◽  
The Impact

Currently, one of the main threats to human health is undoubtedly endocrine disruptors (ED), since they directly disrupt the processes of homeostasis maintenance, controlled by the endocrine system, the purpose of which is to maintain normal functions and development in a constantly changing environment. Pesticides can disrupt the physiological functioning of many endocrine axes, including the endocrine mechanisms that ensure reproductive health. It should be noted that research aimed at preventing chemically induced reproductive disorders in the human population is one of the central areas of preventive medicine, both in terms of their importance and the complexity of the tasks being solved. Analysis and generalization of the results of our own long-term studies have shown that the selective, and, therefore, the most dangerous toxicity of pesticides for the reproductive system is determined by endocrine-mediated mechanisms of etiopathogenesis. The low level of doses inducing pathological changes in reproductive function in our studies fully confirms one of the universal signs inherent in endocrine-distruptive compounds. The above examples demonstrate a wide range of possible endocrine-mediated mechanisms of reproductive toxicity of pesticides - endocrine disruptors. However, it is very important to note that low doses may be more effective in changing some endpoints compared to high (toxic) doses. Currently, several mechanisms have been identified and studied that demonstrate how hormones and ED induce non-monotonic reactions in animal cells, tissues and organs. The reproductive system, the functioning of which is ensured by a fine balancing of the action of androgens and estrogens, is one of the systems that presents a unique opportunity for modeling a non-monotonic dose dependence. All of the above indicates the extreme danger of the impact of hormonally active agents on the reproductive health of a person and his offspring. At the same time, the threat of endocrine-mediated disorders for subsequent generations can also be realized through the induction of mechanisms of development of epigenetic transgenerational effects. Taking into account the results of studies of the mechanisms of the ED destructive action, as well as their ability to induce non-monotonic dose dependence at an extremely low dose level, it should be admitted that, apparently, there is a need to revise the paradigm of methodological approaches to the regulation of pesticides with endocrine-disruptive properties. Key words: pesticides, endocrine disruptors, reproductive system

Endocrine disruptors and reproductive health: The case of bisphenol-A

2006 ◽  
Vol 254-255 ◽  
pp. 179-186 ◽  
Author(s):  
Maricel V. Maffini ◽  
Beverly S. Rubin ◽  
Carlos Sonnenschein ◽  
Ana M. Soto
Keyword(s):  
Reproductive Health ◽  
Bisphenol A ◽  
Endocrine Disruptors

scholarly journals Endocrine disruptive compounds and male reproduction

2018 ◽  
Vol 6 (4) ◽  
pp. 131-134
Author(s):  
Ješeta Michal ◽  
Chmelíková Eva ◽  
Crha Igor ◽  
Sedmíková Markéta ◽  
Žáková Jana ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Endocrine Disruptors ◽  
Hormonal Regulation ◽  
Sperm Quality ◽  
Postnatal Period ◽  
Male Reproduction ◽  
Testicular Development ◽  
Negative Effects ◽  
Hormone Synthesis ◽  
The Impact

AbstractEndocrine disruptors (EDs) are chemical substances that affect physiological processes in the organism via hormonal regulation. The EDs are present in the environment and objects of everyday use. They are often detected in food, particularly released from packaging of canned food, but also from plastic water bottles, and they are also found in cosmetics and fertilizers. They are commonly detected in children's toys, banknotes, receipts and many more objects. Permanent and long-term utilization of EDs has harmful effects on human reproductive health mainly by interference with sex hormone synthesis and mechanism of action. The endocrine disruptors show many negative effects on male reproductive system. Any change during synthesis or activity of sex hormones can cause abnormal reproduction, including developmental anomalies of the sexual system, disruption of testicular development or deterioration of sperm quality. Mainly the impact on the development of testicles in prenatal and early postnatal period can be crucial for reproductive health in males. This review provides an overview of the EDs and their possible impact on reproductive health in males with focus on sperm quality and development of testicles.

scholarly journals Estrogen suppresses SOX9 and activates markers of female development in a human testis-derived cell line

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Melanie K. Stewart ◽  
Deidre M. Mattiske ◽  
Andrew J. Pask
Keyword(s):  
Reproductive Health ◽  
Cell Line ◽  
Cell Fate ◽  
Sertoli Cell ◽  
Endocrine Disruptors ◽  
Estrogen Receptor Alpha ◽  
Human Testis ◽  
Mrna Levels ◽  
Cell Fate Decisions ◽  
Estrogen Exposure

Abstract Background The increasing incidence of reproductive disorders in humans has been attributed to in utero exposure to estrogenic endocrine disruptors. In particular, exposure of the developing testis to exogenous estrogen can negatively impact male reproductive health. To determine how estrogens impact human gonad function, we treated the human testis-derived cell line NT2/D1 with estrogen and examined its impact on SOX9 and the expression of key markers of granulosa (ovarian) and Sertoli (testicular) cell development. Results Estrogen successfully activated its cognate receptor (estrogen receptor alpha; ESR1) in NT2/D1 cells. We observed a significant increase in cytoplasmic SOX9 following estrogen treatment. After 48 h of estrogen exposure, mRNA levels of the key Sertoli cell genes SOX9, SRY, AMH, FGF9 and PTGDS were significantly reduced. This was followed by a significant increase in mRNA levels for the key granulosa cell genes FOXL2 and WNT4 after 96 h of estrogen exposure. Conclusions These results are consistent with estrogen's effects on marsupial gonads and show that estrogen has a highly conserved impact on gonadal cell fate decisions that has existed in mammals for over 160 million years. This effect of estrogen presents as a potential mechanism contributing to the significant decrease in male fertility and reproductive health reported over recent decades. Given our widespread exposure to estrogenic endocrine disruptors, their effects on SOX9 and Sertoli cell determination could have considerable impact on the adult testis.

scholarly journals Endocrine disruptors in breeding ponds and reproductive health of toads in agricultural, urban and natural landscapes

2018 ◽  
Vol 634 ◽  
pp. 1335-1345 ◽  
Author(s):  
Veronika Bókony ◽  
Bálint Üveges ◽  
Nikolett Ujhegyi ◽  
Viktória Verebélyi ◽  
Edina Nemesházi ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Endocrine Disruptors ◽  
Natural Landscapes

scholarly journals Environmental exposure to endocrine disruptors and male reproductive health. Preliminary results.

2018 ◽  
Vol 28 (suppl_4) ◽  
Author(s):  
E Dziewirska ◽  
J Jurewicz ◽  
R Walczak-Jedrzejowska ◽  
W Hanke ◽  
P Kaluzny ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Endocrine Disruptors ◽  
Environmental Exposure ◽  
Preliminary Results ◽  
Male Reproductive Health

Reproductive Health Law Changes Expected

2009 ◽  
Vol 40 (1) ◽  
pp. 38
Author(s):  
MARY ELLEN SCHNEIDER
Keyword(s):  
Reproductive Health ◽  
Health Law
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