scholarly journals Role of Cholesterol as a Risk Factor in Cardiovascular Diseases

2018 ◽  
Author(s):  
Eyup Avci ◽  
Ahmet Dolapoglu ◽  
Didar Elif Akgun
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases

scholarly journals The role of nonesterified fatty acids in pathogenesis of cardiovascular diseases

2010 ◽  
Vol 16 (1) ◽  
pp. 93-103 ◽  
Author(s):  
M. V. Tsvetkova ◽  
V. N. Khirmanov ◽  
N. N. Zybina
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Adipose Tissue ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Sudden Death

The paper reviews publications concerned the role of nonesterifi ed fatty acids (NEFA) in pathogenesis of cardiovascular diseases. NEFAs are four and more carbons chain length carbonic acids and they are presented in free form (nonesterifi ed) in human body. Plasma NEFAs are produced by the adipose tissue triglyceride lipolysis, another source are lipoproteins such as chylomicrons, very low density lipoproteins and intermediate density lipoproteins. Elevated NEFA concentrations in plasma are the risk factor of cardiovascular diseases and type 2 diabetes mellitus and the independent risk factor of hypertension and sudden death. NEFA plasma concentration is elevated in atherosclerosis, acute myocardial infarction, diabetes mellitus, obesity, hypertension, and often in metabolic syndrome. A probable cause of NEFAs accumulation in plasma may be overeating and low physical activity, which result in increase of adipose tissue mass, lipolysis intensifi cation and elevation of NEFAs concentration in plasma. The role of elevated plasma NEFA concentration in a number of conditions (abdominal obesity, atherogenic dyslipidemia, insulin resistance, type 2 diabetes mellitus, endothelial dysfunction, vascular infl ammation, atherosclerosis, hypertension, ischemic heart disease, rhythm disturbances, sudden death) and possible ways of their correction are discussed.

scholarly journals Adipokines and Inflammation: Focus on Cardiovascular Diseases

2020 ◽  
Vol 21 (20) ◽  
pp. 7711 ◽  
Author(s):  
Sandra Feijóo-Bandín ◽  
Alana Aragón-Herrera ◽  
Sandra Moraña-Fernández ◽  
Laura Anido-Varela ◽  
Estefanía Tarazón ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Low Grade ◽  
Bioactive Substances ◽  
Endocrine Organ ◽  
Adipose Tissue Dysfunction ◽  
Inflammatory Processes ◽  
Regulatory Functions

It is well established that adipose tissue, apart from its energy storage function, acts as an endocrine organ that produces and secretes a number of bioactive substances, including hormones commonly known as adipokines. Obesity is a major risk factor for the development of cardiovascular diseases, mainly due to a low grade of inflammation and the excessive fat accumulation produced in this state. The adipose tissue dysfunction in obesity leads to an aberrant release of adipokines, some of them with direct cardiovascular and inflammatory regulatory functions. Inflammation is a common link between obesity and cardiovascular diseases, so this review will summarise the role of the main adipokines implicated in the regulation of the inflammatory processes occurring under the scenario of cardiovascular diseases.

scholarly journals Influence of androgen deficiency on carbohydrate metabolism in men

2017 ◽  
Vol 14 (3) ◽  
pp. 19-24 ◽  
Author(s):  
Ashot M. Mkrtumyan ◽  
Lilit V. Egshatyan
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Carbohydrate Metabolism ◽  
Clinical Data ◽  
Current Literature ◽  
Androgen Deficiency ◽  
General Physicians ◽  
Deficiency Cases

The article provides an overview of the current literature integrating clinical data on the role of androgen deficiency in pathogenesis of metabolic malfunctions and diabetes mellitus. The combination of androgen deficiency and diabetes mellitus is a risk factor of cardiovascular diseases. Due to the fact that general physicians, endocrinologist dont have knowledge of this problem most of androgen deficiency cases are not only remained without treatment but also not revealed.

scholarly journals Intestinal microbiota – a new risk factor in cardiovascular diseases

2021 ◽  
pp. 26-33
Author(s):  
I.N. Lyapina ◽  
◽  
P.N. Zavyrylina ◽  
L.V. Nacheva ◽  
◽  
...  
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Intestinal Microbiota ◽  
Human Microbiome ◽  
Individual Variability ◽  
Intestinal Dysbiosis ◽  
Incidence And Mortality ◽  
Mechanisms Of Development ◽  
Pharmacologically Active

Th e search for new mechanisms of development and progression of cardiovascular diseases (CVD) remains relevant. In recent times, signifi cant attention has been drawn to investigation of the role of intestinal microbiota as a risk factor in different of metabolic disorders and CVD development. In pathological conditions, microbiota may act as an independent factor defi ning the adverse prognosis of the disease, exert infl uence on drug metabolism and facilitate production of pharmacologically active secondary metabolites capable of inducing side eff ects. Th is review presents data on the connection between intestinal dysbiosis and arterial hypertension and chronic heart failure and also discusses methods and new developments aimed at dysbiosis correction. Attention is focused on important aspects of personalised therapy for patients with consideration for the infl uence of human microbiome on individual variability of the reaction to medicinal products. In light of the high incidence and mortality of CVD, active studying of intestinal microbiota and the search for means of dysbiosis correction will make it possible to obtain additional tools for management of the risks of cardiovascular pathology development.

scholarly journals EPIGENETIC AND MOLECULAR AND GENETIC ASPECTS OF OBESITY AS A RISK FACTOR OF CARDIOVASCULAR CATASTROPHES

2020 ◽  
Vol 5 (7(76)) ◽  
pp. 39-44
Author(s):  
Victoria Vladimirovna Kireeva ◽  
Svetlana Aleksandrovna Lepekhova ◽  
Lyubov Nazirovna Mansurova ◽  
Saryuna Chingisovna Dugarova
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Personalized Medicine ◽  
Cardiovascular System ◽  
Genetic Basis ◽  
Risk Groups ◽  
External Influence ◽  
Preventive Activity

The review provides current information of obesity in the pathogenesis of cardiovascular diseases the leading cause of death. Showing the genetic basis for the development of metabolic syndrome. The question of external influence on genes, mutations in which lead to the development of obesity is determined. The question of the possible role of exogenous destroyers in the development of metabolic syndrome is considered. The main genes involved in monogenic and polygenic variants of obesity are identified. The review shows that to prevent the development of metabolic syndrome, it is necessary to form risk groups and to take mandatory preventive activity in these groups. Pathogenetic significance determines the attention of clinicians to this pathology, and the molecular and genetic aspects of formation the cardiovascular diseases dictate the need for personalized medicine to predict and prevent, and pharmacogenetics to correct obesity, metabolic syndrome and the cardiovascular system as a whole.

Periodontal health: A forgotten cornerstone for overall health

2018 ◽  
Author(s):  
Carlos Albuquerque
Keyword(s):  
Risk Factor ◽  
Oral Health ◽  
Cardiovascular Diseases ◽  
Pregnancy Outcomes ◽  
Clinical Evidence ◽  
Adverse Pregnancy Outcomes ◽  
Oral Diseases ◽  
Periodontal Health ◽  
Adverse Pregnancy

Scientific and clinical evidence shows periodontal and systemic healths are closely linked. Periodontitis is a recognized risk factor for several systemic conditions, such as cardiovascular diseases, diabetes and adverse pregnancy outcomes. Nevertheless, the role of oral diseases in overall health is greatly underestimated by most physicians and patients. It is essential develop measures focused on enhancing physicians and patients’ perception of the importance of oral health.

scholarly journals New Insights on Low Vitamin D Plasma Concentration as a Potential Cardiovascular Risk Factor.

2018 ◽  
Vol 12 (1) ◽  
pp. 261-278 ◽  
Author(s):  
Mattia Bellan ◽  
Paolo Marzullo
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Current Evidence ◽  
Natural Consequence ◽  
Vitamin D Levels ◽  
Health And Disease

The role of Vitamin D hormone in human health and disease is still debated. Recently, growing attention has been paid to its putative role in cardiovascular system homeostasis with several studies that suggested a correlation between low vitamin D levels and increased cardiovascular risk. Several mechanisms are involved in the development of cardiovascular diseases: systemic inflammation, endothelial dysfunction, arterial hypertension and insulin resistance. In the present paper, we have revised the current literature supporting a role for vitamin D in the development of these pathogenetic processes. Finally, we have evaluated the current evidence linking vitamin D to atherosclerosis and its natural consequence, cardiovascular diseases.

Role of intestinal microbiota in cardiovascular diseases

2020 ◽  
Vol 18 (1) ◽  
pp. 54-59
Author(s):  
R. A. FAYZULLINA ◽  
◽  
K. A. SAFINA ◽  
Keyword(s):  
Cardiovascular Diseases ◽  
Intestinal Microbiota
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