scholarly journals Aberrant SGK1 Transcription in LNCaP: A Novel Feed-back Mechanism of TGF-beta1 Regulation in Prostate Carcinogenesis

2018 ◽  
Author(s):  
Ximena Leighton ◽  
Harvey B. Pollard ◽  
Meera Srivastava
Keyword(s):  
Prostate Carcinogenesis

398: Administration of Antioxidants Prevents the Development of Prostate Carcinogenesis in Lady Tramp Mice

2004 ◽  
Vol 171 (4S) ◽  
pp. 105-105
Author(s):  
Vasundara Venkateswaran ◽  
Haiyan Xu ◽  
Neil E. Fleshner ◽  
Linda Sugar ◽  
Laurence H. Klotz
Keyword(s):  
Prostate Carcinogenesis ◽  
Tramp Mice

Growth factors involved in prostate carcinogenesis

10.2741/1625 ◽  
2005 ◽  
Vol 10 (1-3) ◽  
pp. 1355 ◽  
Author(s):  
Suman, Kambhampati
Keyword(s):  
Growth Factors ◽  
Prostate Carcinogenesis

Prostate Carcinogenesis: Insights in relation to Epigenetics and Inflammation.

2020 ◽  
Vol 20 ◽  
Author(s):  
Mirazkar D. Pandareesh ◽  
Vivek Hamse Kameshwar ◽  
Kullaiah K. Byrappa
Keyword(s):  
Prostate Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Human Cancer ◽  
Control Cell ◽  
Diagnosis And Treatment ◽  
Epigenetic Changes ◽  
Mesenchymal Transition ◽  
Prostate Carcinogenesis ◽  
History Of ◽  
Clinical Potential

: Prostate cancer is a multifactorial disease that mainly occurs due to the accumulation of somatic, genetic and epigenetic changes, resulting in the inactivation of tumor-suppressor genes and activation of oncogenes. Mutations in genes, specifically those that control cell growth and division or the repair of damaged DNA, make the cells grow and divide uncontrollably to form a tumor. The risk of developing prostate cancer depends upon the gene that has undergone the mutation. Identifying such genetic risk factors for prostate cancer pose a challenge for the researchers. Besides genetic mutations, many epigenetic alterations including DNA methylation, histone modifications (methylation, acetylation, ubiquitylation, sumoylation, and phosphorylation) nucleosomal remodelling, and chromosomal looping, have been significantly contributed to the onset of prostate cancer as well as the prognosis, diagnosis, and treatment of prostate cancer. Chronic inflammation also plays a major role in the onset and progression of human cancer, via. modifications in the tumor microenvironment by initiating epithelial-mesenchymal transition and remodelling the extracellular matrix. In this article, the authors present a brief history of the mechanisms and potential links between the genetic aberrations, epigenetic changes, inflammation and inflammasomes that are known to contribute to the prognosis of prostate cancer. Furthermore, the authors examine and discuss clinical potential of prostate carcinogenesis in relation to epigenetics and inflammation for its diagnosis and treatment.

scholarly journals Inhibition of prostate carcinogenesis by combined active immunoprophylaxis

2007 ◽  
Vol 121 (1) ◽  
pp. 88-94 ◽  
Author(s):  
Carla De Giovanni ◽  
Stefania Croci ◽  
Giordano Nicoletti ◽  
Lorena Landuzzi ◽  
Arianna Palladini ◽  
...  
Keyword(s):  
Prostate Carcinogenesis
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