Inflammation in Prostate Carcinogenesis: Role of the Tumor Suppressor Par-4

2012 ◽  
Author(s):  
Maria T. Diaz-Meco
Keyword(s):  
Tumor Suppressor ◽  
Prostate Carcinogenesis

Tumor suppressor role of chromatin-remodeling factor ARID1A

2013 ◽  
Vol 35 (3) ◽  
pp. 255-261 ◽  
Author(s):  
Xiao-Qiang GUO ◽  
Qiao-Xia ZHANG ◽  
Wei-Ren HUANG ◽  
Xiang-Lin DUAN ◽  
Zhi-Ming CAI
Keyword(s):  
Tumor Suppressor ◽  
Chromatin Remodeling

Role of Regulatory Oncogenic or Tumor Suppressor miRNAs of PI3K/AKT Signaling Axis in the Pathogenesis of Colorectal Cancer

2019 ◽  
Vol 24 (39) ◽  
pp. 4605-4610 ◽  
Author(s):  
Atena Soleimani ◽  
Farzad Rahmani ◽  
Gordon A. Ferns ◽  
Mikhail Ryzhikov ◽  
Amir Avan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Suppressor ◽  
Current Knowledge ◽  
Akt Signaling ◽  
Tumor Tissues ◽  
Radio Therapy ◽  
Signaling Axis ◽  
Cancer Tumor ◽  
Novel Biomarkers

Colorectal cancer (CRC) is the leading cause of cancer death worldwide and its incidence is increasing. In most patients with CRC, the PI3K/AKT signaling axis is over-activated. Regulatory oncogenic or tumor suppressor microRNAs (miRNAs) for PI3K/AKT signaling regulate cell proliferation, migration, invasion, angiogenesis, as well as resistance to chemo-/radio-therapy in colorectal cancer tumor tissues. Thus, regulatory miRNAs of PI3K/AKT/mTOR signaling represent novel biomarkers for new patient diagnosis and obtaining clinically invaluable information from post-treatment CRC patients for improving therapeutic strategies. This review summarizes the current knowledge of miRNAs’ regulatory roles of PI3K/AKT signaling in CRC pathogenesis.

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