scholarly journals Evaluation of the Biotribological Behavior and Cytotoxicity of Laser-Textured ISO 5832-1 Stainless Steel for Use in Orthopedic Implants

2018 ◽  
Author(s):  
Eurico Felix Pieretti ◽  
Andrea Cecília Dorión Rodas ◽  
Renato Altobelli Antunes ◽  
Maurício David Martins das Neves
Keyword(s):  
Stainless Steel ◽  
Orthopedic Implants

scholarly journals Direct-Contact Cytotoxicity Evaluation of CoCrFeNi-Based Multi-Principal Element Alloys

2018 ◽  
Vol 9 (4) ◽  
pp. 59 ◽  
Author(s):  
Ryan Newell ◽  
Zi Wang ◽  
Isabel Arias ◽  
Abhishek Mehta ◽  
Yongho Sohn ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Direct Contact ◽  
Orthopedic Implants ◽  
Cell Number ◽  
In Vitro Cytotoxicity ◽  
Principal Element ◽  
Surface Corrosion ◽  
Alamarblue Assay ◽  
Control Samples

Transition metal multi-principal element alloys (MPEAs) are novel alloys that may offer enhanced surface and mechanical properties compared with commercial metallic alloys. However, their biocompatibility has not been investigated. In this study, three CoCrFeNi-based MPEAs were fabricated, and the in vitro cytotoxicity was evaluated in direct contact with fibroblasts for 168 h. The cell viability and cell number were assessed at 24, 96, and 168 h using LIVE/DEAD assay and alamarBlue assay, respectively. All MPEA sample wells had a high percentage of viable cells at each time point. The two quaternary MPEAs demonstrated a similar cell response to stainless steel control with the alamarBlue assay, while the quinary MPEA with Mn had a lower cell number after 168 h. Fibroblasts cultured with the MPEA samples demonstrated a consistent elongated morphology, while those cultured with the Ni control samples demonstrated changes in cell morphology after 24 h. No significant surface corrosion was observed on the MPEAs or stainless steel samples following the cell culture, while the Ni control samples had extensive corrosion. The cell growth and viability results demonstrate the cytocompatibility of the MPEAs. The biocompatibility of MPEAs should be investigated further to determine if MPEAs may be utilized in orthopedic implants and other biomedical applications.

scholarly journals Uji Biokompabilitas pada Implan Orthopedi Antara Implan Impor, Implan Lokal dari Material Impor, dan Prototipe Stainless Steel 316L dari Material Lokal

2019 ◽  
Vol 3 (1) ◽  
pp. 7
Author(s):  
Ferdiansyah Mahyudin ◽  
Heppy Chandra Waskita ◽  
Dwikora Novembri Utomo ◽  
Heri Suroto ◽  
Tri Wahyu Martanto
Keyword(s):  
Stainless Steel ◽  
Acute Toxicity ◽  
Mtt Assay ◽  
Orthopedic Implants ◽  
Fibrous Capsule ◽  
Cytotoxicity Test ◽  
Stainless Steel 316L ◽  
Medical Test ◽  
Significant Difference ◽  
One Way Anova

ABSTRACT  Demands of orthopedic implants are increasing in Indonesia, but its production are limited and still imported. Stainless steel, especially 316L is one of metal that is used commonly. This research evaluates biocompatibility of stainless steel 316L implant prototype, local implant manufactured using imported stainless steel, and imported stainless steel implant. Cytotoxicity test used mesenchymal human cell with MTT assay. Irritation test, acute toxicity/pyrogenicity test, and implantation test used 24 Wistar rats respectively which were assigned to 4 groups. We evaluate Draize score, weight and rectal temperature changes, and fibrous capsule ring thickness. Cytotoxicity test shows viable cell percentage in stainless steel 316L implant prototype, local implant, and imported implant are 83.7%, 87.5%, and 83.7% respectively. Comparison test using One Way ANOVA shows no significant difference between 3 groups (p>0.05). Iritation test results in 3 groups are grade 0 (no edema and no erythema). Acute toxicity/pyrogenicity test shows no statistically significant difference (p>0.05) among all groups. There is also no significant difference (p>0.05) of fibrous capsule ring thickness on 1 and 4 weeks after implantation. Based on ISO for medical test guide, stainless steel 316L implant prototype is safe and has similar biocompatibility test result compared to local and imported implant.Keywords                   : stainless steel 316L, biocompatibility, orthopaedic implantCorrespondence to    : [email protected] ABSTRAKKebutuhan implan orthopedi terus meningkat di Indonesia, namun produksinya terbatas dan sebagian besar masih impor dari luar negeri. Stainless steel, utama 316L adalah salah satu metal yang sering digunakan. Penelitian ini mengevaluasi biokompatibilitas dari prototipe implan stainless steel 316L, implan lokal yang diproduksi menggunakan stainless steel impor, dan implan stainless steel impor. Uji sitotoksisitas menggunakan sel mesenkim human dengan MTT assay. Uji iritasi, uji pirogenositas, dan uji implantasi menggunakan 24 tikus Wistar yang terbagi dalam 4 grup. Kami mengevaluasi skor Draize, perubahan berat dan temperatur rektal, dan ketebalan fibrous capsule ring. Uji sitotoksisitas menunjukkan persentase viabilitas sel pada prototipe stainless steel 316L, implan lokal, dan implan impor berturut-turut adalah 83,7%; 87,5%; dan 83,7%. Uji komparasi dengan One Way Anova tidak menunjukkan perbedaan signifikan diantara 3 grup (p>0,05). Hasil uji iritasi 3 grup menunjukkan grade 0 (tidak ada edema dan eritema). Uji pirogenositas tidak menunjukkan perbedaan signifikan pada semua grup (p>0,05). Tidak ada perbedaan signifikan (p>0,05) pula pada ketebalan fibrous capsule ring di minggu ke 1 dan 4 setelah implantasi. Berdasarkan ISO untuk pedoman uji di bidang medis, prototipe stainless steel 316L aman dan memiliki kesamaan hasil uji biokompatibilitas bila dibandingkan dengan implan lokal dan impor.Kata kunci              : stainless steel 316L, uji biokompatibilitas, implan orthopaediKorespondensi       : [email protected]

Corrosion Resistance of Nickel-Free Austenitic Stainless Steels and their Nanocomposites with Hydroxyapatite in Ringer's Solution

2011 ◽  
Vol 674 ◽  
pp. 159-163 ◽  
Author(s):  
Maciej Tulinski ◽  
Mieczyslaw Jurczyk
Keyword(s):  
Stainless Steel ◽  
Corrosion Resistance ◽  
Mechanical Alloying ◽  
Stainless Steels ◽  
Austenitic Stainless Steels ◽  
Orthopedic Implants ◽  
Corrosion Current ◽  
Similar Process ◽  
Distinct Advantage ◽  
Ion Release

In this work Ni-free austenitic stainless steels with nanostructure and their nanocomposites were synthesized by mechanical alloying (MA), heat treatment and nitriding of elemental microcrystalline Fe, Cr, Mn and Mo powders with addition of hydroxyapatite (HA). Microhardness and corrosion tests' results of obtained materials are presented. Mechanical alloying and nitriding are very effective technologies to improve the corrosion resistance of stainless steel. Decreasing the corrosion current density is a distinct advantage for prevention of ion release and it leads to better cytocompatibility. Similar process in case of nanocomposites of stainless steel with hydroxyapatite helps achieve even better mechanical properties and corrosion resistance. Hence nanocrystalline nickel-free stainless steels and nickel-free stainless steel/hydroxyapatite nanocomposites could be promising bionanomaterials for use as a hard tissue replacement implants, e.g. orthopedic implants.

Surface Modification of Stainless Steel Orthopedic Implants by Sol–Gel ZrTiO4 and ZrTiO4–PMMA Coatings

2013 ◽  
Vol 9 (8) ◽  
pp. 1327-1335 ◽  
Author(s):  
E. Salahinejad ◽  
M. J. Hadianfard ◽  
D. D. Macdonald ◽  
S. Sharifi(Asl) ◽  
M. Mozafari ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Surface Modification ◽  
Sol Gel ◽  
Orthopedic Implants

scholarly journals In Vitro Electrochemical Corrosion and Cell Viability Studies on Nickel-Free Stainless Steel Orthopedic Implants

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e61633 ◽  
Author(s):  
Erfan Salahinejad ◽  
Mohammad Jafar Hadianfard ◽  
Digby Donald Macdonald ◽  
Samin Sharifi-Asl ◽  
Masoud Mozafari ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Cell Viability ◽  
Electrochemical Corrosion ◽  
Orthopedic Implants

scholarly journals Durable Polymeric N-halamine Functionalized Stainless Steel Surface for Improved Antibacterial and Anti-biofilm Activity

2021 ◽  
Author(s):  
Rajani Kant Rai ◽  
Hemalatha Kanniyappan ◽  
Vignesh Muthuvijayan ◽  
Venkitasamy Kesavan ◽  
A. Jayakrishnan
Keyword(s):  
Stainless Steel ◽  
Water Purification ◽  
Food Processing ◽  
Bacterial Adhesion ◽  
Steel Surface ◽  
Antibacterial Properties ◽  
Orthopedic Implants ◽  
Surgical Instruments ◽  
Stainless Steel Surface

Bacterial adhesion and colonization on stainless steel (SS) based surgical instruments, hospital equipments, orthopedic implants, water purification and food processing units are a major problem. Imparting rechargeable antibacterial properties to...

scholarly journals Calculating the Power Demand in Turning of AISI 316L Stainless Steel Through the Cutting Forces Data

2016 ◽  
Vol 3 (1) ◽  
pp. 43
Author(s):  
Rusdi Nur
Keyword(s):  
Stainless Steel ◽  
Austenitic Stainless Steel ◽  
Metal Cutting ◽  
Orthopedic Implants ◽  
Practical Calculation ◽  
Power Demand ◽  
Aisi 316L ◽  
Aisi 316L Stainless Steel ◽  
Mathematical Expressions ◽  
Steel Aisi

Abstract—Austenitic stainless steel AISI 316L has been widely used for orthopedic implants due to its mechanical properties, corrosion resistance and biocompatibility. Machining of austenitic stainless steel are often regarded as 'difficult to machine' and classed a single group of steels, based on experience with the most common austenitic types. This paper presents a methodology for practical calculation of power demand based on cutting force that will be compared with experimental results especially turning process. Based on a previously proposed definition, the power demand in metal cutting is the energy required cutting. This paper provides a complete list of mathematical expressions needed for the calculation of power demand and demonstrates their utility for turning operation of austenitic stainless steel using coated and uncoated carbide.

scholarly journals A study on corrosion resistance of ISO 5832-1 austenitic stainless steel used as orthopedic implant

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Lilian N. M. Braguin ◽  
Caio A. J. da Silva ◽  
Larissa O. Berbel ◽  
Isolda Costa ◽  
Mitiko Saiki
Keyword(s):  
Stainless Steel ◽  
Corrosion Resistance ◽  
Austenitic Stainless Steel ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Chemical Elements ◽  
Simulated Body Fluid Solution ◽  
Orthopedic Implants ◽  
Localized Corrosion ◽  
Electrochemical Tests

The ISO 5832-1 austenitic stainless steel used as biomaterial is largely applied in the area of orthopedics, especially in the manufacture of implants, such as temporary or permanent replacement of bone structures. The objective of this study was to evaluate the localized corrosion resistance of the ISO 5832-1 stainless steel used in orthopedic implants by electrochemical tests in two different solutions. The results of this study are of great interest to evaluate the corrosion of metallic implants that can result in the release of corrosion products into bodily fluids causing possible adverse biological reactions. The determination of the chemical elements in the composition of the ISO 5832-1 stainless steel was performed by neutron activation analysis (NAA). The samples for electrochemical tests were grinded with silicon carbide paper up to #4000 finishing, followed by mechanical polishing with diamond paste. The open circuit potential measurements and anodic polarization curves were obtained in solution of 0.90 wt. % of NaCl and of simulated body fluid (SBF). The results indicated that the ISO 5832-1 stainless steel presented a high resistance to crevice corrosion in simulated body fluid solution but high susceptibility to this form of corrosion in the chloride solution.  

Cytocompatibility of High Nitrogen Nickel-Free Stainless Steel for Orthopedic Implants

2012 ◽  
Vol 28 (7) ◽  
pp. 647-653 ◽  
Author(s):  
Tianchi Ma ◽  
Peng Wan ◽  
Yuyan Cui ◽  
Guirong Zhang ◽  
Jiqiang Li ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Orthopedic Implants ◽  
High Nitrogen
Sign in / Sign up

Export Citation Format

Share Document