scholarly journals Possibilities to Limit the Values of Clinical and Biochemical Parameters in Experimental Arterial Hypertension

2018 ◽  
Author(s):  
Manuela Ciocoiu ◽  
Bogdan Mihail Diaconescu ◽  
Codruta Badescu
Keyword(s):  
Arterial Hypertension ◽  
Biochemical Parameters

Influence of spironolactone on the arterial pressure and certain biochemical parameters in rats with arterial hypertension

1987 ◽  
Vol 21 (9) ◽  
pp. 607-610
Author(s):  
A. A. Boldyrev ◽  
A. V. Kamernitskii ◽  
A. A. Kotlobai ◽  
A. L. Markel
Keyword(s):  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Biochemical Parameters

Evaluation of the Effects of a Pinus Brutia Bark Extract on Biochemical Parameters and Blood Pressure in an Experimental Arterial Hypertension

2018 ◽  
Vol 69 (7) ◽  
pp. 1718-1721 ◽  
Author(s):  
Catrinel Florentina Paduraru(Giurescu Bedreag) ◽  
Nina Filip ◽  
Adriana Trifan ◽  
Sorin Dan Miron ◽  
Codruta Badescu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Biochemical Parameters ◽  
Bark Extract ◽  
Pinus Brutia ◽  
Target Organs ◽  
Induced Hypertension ◽  
Oxidative Effects ◽  
And Oxidative Stress

The new hypertension therapies which are thought to improve the mechanisms impairing the target organs in arterial hypertension (AHT) would have great practical value. The aim of our study was to investigate the effects of Pinus brutia bark extract (EPb) on serum lipid profiles and oxidative stress in N(G)-Nitro-L-arginine-methyl ester (L-NAME)-induced hypertension. The experiment demonstrated that PbE improved lipid profile and reduced pro-oxidative effects of L-NAME, thus suggesting a possible role of the extract in the management of AHT. Systolic and diastolic blood pressure decrease was significant in the group undergoing simultaneous EPb extract and L-NAME therapy, as compared to the group that was administered only L-NAME. Due to its effects, the Pinus brutia bark extract may be used for the prophylaxis and as adjuvant therapy of cardiovascular conditions.

The contribution of biochemical parameters to the diagnosis of lesions of target organs in patients with arterial hypertension and abdominal obesity

2019 ◽  
Vol 493 ◽  
pp. S171-S172
Author(s):  
T. Petelina ◽  
K. Avdeeva ◽  
N. Musikhina ◽  
L. Gapon ◽  
A. Kostousova ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Abdominal Obesity ◽  
Biochemical Parameters ◽  
Target Organs

scholarly journals The Vascular Wall State and Microcirculation Parameters in Patients with Controlled and Uncontrolled Arterial Hypertension

2019 ◽  
Vol 15 (4) ◽  
pp. 495-501
Author(s):  
V. I. Podzolkov ◽  
A. E. Bragina ◽  
D. U. Natkina ◽  
T. A. Safronova ◽  
N. N. Nebieridze ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Biochemical Parameters ◽  
Asymmetric Dimethylarginine ◽  
Pulse Wave ◽  
Normal Values ◽  
Vascular Wall ◽  
Cognitive Status ◽  
Significant Relation ◽  
Large Vessels

Aim. To study the rigidity of the vascular wall and microcirculation parameters in patients with uncontrolled (UCAH) and controlled arterial hypertension (CAH).Material and methods. 134 patients with essential hypertension were included, among them 88 (65.7%) patients with UCAH and 46 (34.3%) patients with CAH. Patients in both groups were similar by sex, age, duration of hypertension and some biochemical parameters. Patients had a study of the parameters of stiffness of the vascular wall, microcirculation parameters, as well as an evaluate of the plasma level of asymmetric dimethylarginine (ADMA).Results. Pulse wave velocity (PWV) did not differed between the UCAH and CAH, both in absolute values (1144 [1000-1290] vs 1138 [10281279] cm/sec; p=0.385) and in the frequency of exceeding the normal values (95% vs 92%; p=0.784). Microcirculation index (MI) in CAH was significantly higher than in the UCAH group: 30.55 [27.08-34.4] and 22.82 [18.62-26.05], respectively (p <0.05). ADMA plasma concentration was significantly higher 0.69 [0.62-0.81] μmol/l in UCAH, than in the CAH group 0.62 [0.58-0.70] µmol/l (p <0.05), that shows the presence of endothelial dysfunction. There were detected significant relation between MI and cognitive status.Conclusion. The results of our study indicate the presence of signs of endothelial dysfunction in patients with UCAH with changes in the stiffness of the vascular wall comparable with the CAH group. This may reflect the slower effect of antihypertensive therapy on the remodeling processes of large vessels in comparison with the microvasculature.

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