Influence of spironolactone on the arterial pressure and certain biochemical parameters in rats with arterial hypertension

1987 ◽  
Vol 21 (9) ◽  
pp. 607-610
Author(s):  
A. A. Boldyrev ◽  
A. V. Kamernitskii ◽  
A. A. Kotlobai ◽  
A. L. Markel
Keyword(s):  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Biochemical Parameters

Daily arterial pressure profile in young individuals with hereditary burden due to arterial hypertension

2019 ◽  
Vol 17 (2) ◽  
pp. 42-48
Author(s):  
I. A. Grebenkina ◽  
◽  
A. A. Popova ◽  
S. D. Mayanskaya ◽  
S. V. Tretyakov ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Pressure Profile

Capabilities of daily monitoring of arterial pressure and tests with dosed physical load in diagnostics of arterial hypertension in young athletes

2019 ◽  
Vol 17 (2) ◽  
pp. 74-79 ◽  
Author(s):  
A. A. Shirokova ◽  
◽  
L. A. Balykova ◽  
S. A. Ivyanskiy ◽  
K. N. Varlashina ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Physical Load ◽  
Young Athletes ◽  
Daily Monitoring

scholarly journals Effective blood pressure reduction: results of the regional program “DOVERIE”

2018 ◽  
pp. 57-63 ◽  
Author(s):  
N. V. Dobryninа ◽  
S. S. Yakushin
Keyword(s):  
Blood Pressure ◽  
Clinical Practice ◽  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Generic Drugs ◽  
Blood Pressure Reduction ◽  
Pressure Reduction ◽  
Regional Study

In clinical practice, quite often the practitioner faces difficulties in correcting arterial pressure in patients with arterial hypertension. Patients mostly for various reasons prefer to be treated with generic drugs, sometimes to the detriment of the effectiveness of treatment. The regional study conducted by us clearly showed the presence of additional possibilities of the original drug Prestans (Servier, France) in reducing blood pressure compared to equivalent dosages of generic fixed combinations.

scholarly journals Right ventricle performances with echocardiography and 99mTc myocardial perfusion imaging in pulmonary arterial hypertension patients

2018 ◽  
Vol 243 (9) ◽  
pp. 754-761
Author(s):  
Jie Liu ◽  
Lei Fei ◽  
Guang-Qing Huang ◽  
Xiao-Ke Shang ◽  
Mei Liu ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Myocardial Perfusion ◽  
Arterial Pressure ◽  
Right Ventricle ◽  
Arterial Hypertension ◽  
Pulmonary Arterial Pressure ◽  
Right Heart Catheterization ◽  
Heart Catheterization ◽  
Mean Pulmonary Arterial Pressure ◽  
Pulmonary Arterial

Right heart catheterization is commonly used to measure right ventricle hemodynamic parameters and is the gold standard for pulmonary arterial hypertension diagnosis; however, it is not suitable for patients’ long-term follow-up. Non-invasive echocardiography and nuclear medicine have been applied to measure right ventricle anatomy and function, but the guidelines for the usefulness of clinical parameters remain to be established. The goal of this study is to identify reliable clinical parameters of right ventricle function in pulmonary arterial hypertension patients and analyze the relationship of these clinical parameters with the disease severity of pulmonary arterial hypertension. In this study, 23 normal subjects and 23 pulmonary arterial hypertension patients were recruited from January 2015 to March 2016. Pulmonary arterial hypertension patients were classified into moderate and severe pulmonary arterial hypertension groups according to their mean pulmonary arterial pressure levels. All the subjects were subjected to physical examination, chest X-ray, 12-lead electrocardiogram, right heart catheterization, two-dimensional echocardiography, and technetium 99m (99mTc) myocardial perfusion imaging. Compared to normal subjects, the right heart catheterization indexes including right ventricle systolic pressure, right ventricle end diastolic pressure, pulmonary artery systolic pressure, pulmonary artery diastolic pressure, pulmonary vascular resistance, and right ventricle end systolic pressure increased in pulmonary arterial hypertension patients and were correlated with mean pulmonary arterial pressure levels. Echocardiography parameters, including tricuspid regurgitation peak velocity, tricuspid regurgitation pressure gradient, tricuspid annular plane systolic excursion and fractional area, right ventricle-myocardial performance index, were significantly associated with the mean pulmonary arterial pressure levels in pulmonary arterial hypertension patients. Furthermore, myocardial perfusion imaging was not observed in the normal subjects but in pulmonary arterial hypertension patients, especially severe pulmonary arterial hypertension subgroup, and showed potential diagnostic properties for pulmonary arterial hypertension. In conclusion, mean pulmonary arterial pressure levels are correlated with several right heart catheterization and echocardiography markers in pulmonary arterial hypertension patients; echocardiography and 99mTc myocardial perfusion can be used to evaluate right ventricle performance in pulmonary arterial hypertension patients. Impact statement In this study, we analyzed the clinical parameters for evaluating RV function, including right ventricle catheterization (RHC), echocardiography, and technetium 99m (99mTc) myocardial perfusion imaging (MPI) in normal Asian subjects and PAH patients ( n = 23 for each group). Our results demonstrated that six RHC indexes, four echocardiography indexes and MPI index were significantly altered in PAH patients and correlated with the levels of mean pulmonary arterial pressure. Importantly, we evaluated the diagnostic performance of MPI and found that MPI has a strong diagnostic accuracy in PAH patients. The findings from this study will be of interest to clinical investigators who make diagnosis and therapeutic strategies for PAH patients.

Atrial septal defect closure with an Amplatzer septal occluder fenestrated with a coronary stent in a child with pulmonary arterial hypertension

2012 ◽  
Vol 23 (5) ◽  
pp. 692-696 ◽  
Author(s):  
Gregory J. Skinner ◽  
Robert M. Tulloh ◽  
Andrew J. Tometzki ◽  
Ingram Schulze-Neick ◽  
Gareth J. Morgan
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Atrial Septal Defect ◽  
Septal Defect ◽  
Pulmonary Arterial Pressure ◽  
Severe Disease ◽  
Idiopathic Pulmonary Arterial Hypertension ◽  
Stent Insertion ◽  
Pulmonary Arterial

AbstractThe presence of an atrial septal defect in pulmonary hypertension has benefits and detractions. Even in idiopathic pulmonary arterial hypertension, a significant left-to-right shunt at atrial level may increase the pulmonary arterial pressure and exacerbate the disease. However, it is well recognised that the presence of an atrial communication may be protective in subgroups with severe disease, allowing maintenance of cardiac output during times of increased pulmonary resistance. In the present paper, we present the case of a young boy with significant idiopathic pulmonary arterial hypertension and an atrial septal defect. We report our technique of septal occlusion using a device to decrease left-to-right shunting with concomitant stent insertion in that device to maintain the potential for right-to-left shunting during times of high pulmonary arterial pressure.

scholarly journals Effect of maternal dyslipidaemia on the cardiorespiratory physiology and biochemical parameters in male rat offspring

2017 ◽  
Vol 118 (11) ◽  
pp. 930-941 ◽  
Author(s):  
Keyth Sulamitta L. Guimarães ◽  
Emmanuel Veríssimo de Araújo ◽  
Jailane Souza Aquino ◽  
Danilo Assis Gadelha ◽  
Camille Moura Balarini ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Biochemical Parameters ◽  
Low Frequency ◽  
Hdl Cholesterol ◽  
Wistar Rat ◽  
Serum Levels ◽  
Male Offspring ◽  
Male Rat ◽  
Standard Diet ◽  
Predisposing Factor

AbstractThe present study evaluated the effects of maternal dyslipidaemia on blood pressure (BP), cardiorespiratory physiology and biochemical parameters in male offspring. Wistar rat dams were fed either a control (CTL) or a dyslipidaemic (DLP) diet during pregnancy and lactation. After weaning, both CTL and DLP offspring received standard diet. On the 30th and 90th day of life, blood samples were collected for metabolic analyses. Direct measurements of BP, respiratory frequency (RF), tidal volume (VT) and ventilation (VE) under baseline condition, as well as during hypercapnia (7 % CO2) and hypoxia (KCN, 0·04 %), were recorded from awake 90-d-old male offspring. DLP dams exhibited raised serum levels of total cholesterol (TC) (4·0-fold), TAG (2·0-fold), VLDL+LDL (7·7-fold) and reduced HDL-cholesterol (2·4-fold), insulin resistance and hepatic steatosis at the end of lactation. At 30 d of age, the DLP offspring showed an increase in the serum levels of TC (P<0·05) and VLDL+LDL (P<0·05) in comparison with CTL offspring. At 90 d of age, DLP offspring exhibited higher mean arterial pressure (MAP, approximately 34 %). In the spectral analysis, the DLP group showed augmented low-frequency (LF) power and LF:high-frequency (HF) ratio when compared with CTL offspring. In addition, the DLP animals showed a larger delta variation in arterial pressure after administration of the ganglionic blocker (P=0·0003). We also found that cardiorespiratory response to hypercapnia and hypoxia was augmented in DLP offspring. In conclusion, the present data show that maternal dyslipidaemia alters cardiorespiratory physiology and may be a predisposing factor for hypertension at adulthood.

Variabilty of arterial pressure and renal function

2016 ◽  
Vol 94 (4) ◽  
pp. 245-249
Author(s):  
A. Ya. Kravchenko ◽  
Anna A. Chernykh ◽  
A. V. Budnevsky
Keyword(s):  
Renal Function ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Renal Pathology ◽  
Cardiac Outcomes ◽  
Target Organs ◽  
The Relationship ◽  
Adverse Factor

This review deals with variability of arterial pressure (VAP) as an adverse factor contributing to the development and progression of cardiovascular diseases and renal pathology. VAP has recently attracted much attention in connection with results of ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) showing that VAP is a risk factor of stroke and other complications of arterial hypertension (AH).The relationship between VAP and renal function remains unexplored and is considered to be a vicious circle in which kidneys are both a cause of AH and its target organs. Evidently, elucidation of the relationship between enhanced VAP and renal function is of primary importance.

Pulmonary Arterial Hypertension in Systemic Lupus Erythematosus: Prevalence and Predictors

2015 ◽  
Vol 43 (2) ◽  
pp. 323-329 ◽  
Author(s):  
Gregorio Miguel Pérez-Peñate ◽  
Iñigo Rúa-Figueroa ◽  
Gabriel Juliá-Serdá ◽  
Fernándo León-Marrero ◽  
Antonio García-Quintana ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Pulmonary Hypertension ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Diastolic Dysfunction ◽  
Lupus Erythematosus ◽  
Pulmonary Arterial Pressure ◽  
Systemic Lupus ◽  
Pulmonary Arterial

Objective.Pulmonary arterial hypertension (PAH) prevalence has been reported to be between 0.5% and 17% in systemic lupus erythematosus (SLE). This study assessed PAH prevalence and predictors in an SLE cohort.Methods.The Borg dyspnea scale, DLCO, N-terminal pro–brain natriuretic peptide (NT-proBNP), and Doppler echocardiographic (DE) were performed. An echocardiographic Doppler exercise test was conducted in selected patients. When DE systolic pulmonary arterial pressure was ≥ 45 mmHg or increased during exercise > 20 mmHg, a right heart catheterization was performed. Hemodynamic during exercise was measured if rest mean pulmonary arterial pressure was < 25 mmHg.Results.Of the 203 patients with SLE, 152 were included. The mean age was 44.9 ± 12.3 years, and 94% were women. Three patients had known PAH. The algorithm diagnosed 1 patient with chronic thromboembolic pulmonary hypertension and 5 with exercise-induced pulmonary artery pressure increase (4 with occult left diastolic dysfunction). These patients had significantly more dyspnea, higher NT-proBNP, and lower DLCO.Conclusion.These data confirm the low prevalence of PAH in SLE. In our cohort, occult left ventricular diastolic dysfunction was a frequent diagnosis of unexplained dyspnea. Dyspnea, DLCO, and NT-proBNP could be predictors of pulmonary hypertension in patients with SLE.

scholarly journals Observation of adolescents with high blood pressure, involved in physical activity

2017 ◽  
Vol 8 (2) ◽  
pp. 16-19
Author(s):  
L. A Balykova ◽  
S. A Ivianskiy ◽  
A. A Shirokova ◽  
N. V Shchekina ◽  
K. A Varlashina
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Young People ◽  
Arterial Pressure ◽  
Arterial Hypertension ◽  
High Blood Pressure ◽  
Physical Exertion ◽  
Foreign Experience ◽  
Diagnostic Approaches ◽  
Points Of View

The article provides a brief overview of the literature data on the prevalence and causes of hypertension in athletes. Different points of view on the effect of regular physical exertion on the level of arterial pressure are considered. In addition, the available diagnostic approaches to the detection of high blood pressure are described. Based on the available data, domestic and foreign experience, oftimal algorithms for diagnosing arterial hypertension in young people involved in sports are presented.

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