scholarly journals Graded Cellular Bone Scaffolds

2017 ◽  
Author(s):  
Sakkadech Limmahakhun ◽  
Cheng Yan
Keyword(s):  
Bone Scaffolds ◽  
Cellular Bone

scholarly journals Human decellularized bone scaffolds from aged donors show improved osteoinductive capacity compared to young donor bone

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0177416 ◽  
Author(s):  
Christopher A. Smith ◽  
Tim N. Board ◽  
Paul Rooney ◽  
Mark J. Eagle ◽  
Stephen M. Richardson ◽  
...  
Keyword(s):  
Young Donor ◽  
Bone Scaffolds

scholarly journals Commercial Bone Grafts Claimed as an Alternative to Autografts: Current Trends for Clinical Applications in Orthopaedics

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3290
Author(s):  
Marco Govoni ◽  
Leonardo Vivarelli ◽  
Alessandro Mazzotta ◽  
Cesare Stagni ◽  
Alessandra Maso ◽  
...  
Keyword(s):  
Web Of Science ◽  
Bone Grafts ◽  
Clinical Applications ◽  
Bibliographic Databases ◽  
Market Demand ◽  
Regulatory Issues ◽  
Negative Results ◽  
Current Trends ◽  
Analyse Data ◽  
Cellular Bone

In the last twenty years, due to an increasing medical and market demand for orthopaedic implants, several grafting options have been developed. However, when alternative bone augmentation materials mimicking autografts are searched on the market, commercially available products may be grouped into three main categories: cellular bone matrices, growth factor enhanced bone grafts, and peptide enhanced xeno-hybrid bone grafts. Firstly, to obtain data for this review, the search engines Google and Bing were employed to acquire information from reports or website portfolios of important competitors in the global bone graft market. Secondly, bibliographic databases such as Medline/PubMed, Web of Science, and Scopus were also employed to analyse data from preclinical/clinical studies performed to evaluate the safety and efficacy of each product released on the market. Here, we discuss several products in terms of osteogenic/osteoinductive/osteoconductive properties, safety, efficacy, and side effects, as well as regulatory issues and costs. Although both positive and negative results were reported in clinical applications for each class of products, to date, peptide enhanced xeno-hybrid bone grafts may represent the best choice in terms of risk/benefit ratio. Nevertheless, more prospective and controlled studies are needed before approval for routine clinical use.

SELF-ASSEMBLED SCAFFOLDS USING REACTION–DIFFUSION SYSTEMS: A HYPOTHESIS FOR BONE REGENERATION

2011 ◽  
Vol 11 (01) ◽  
pp. 231-272 ◽  
Author(s):  
DIEGO A. GARZÓN-ALVARADO ◽  
MARCO A. VELASCO ◽  
CARLOS A. NARVÁEZ-TOVAR
Keyword(s):  
Bone Matrix ◽  
Three Dimensional ◽  
Reaction Diffusion ◽  
Tissue Growth ◽  
New Bone Formation ◽  
Reaction Diffusion Systems ◽  
Bone Scaffolds ◽  
Full Control ◽  
Diffusion Systems ◽  
Biomaterial Scaffold

One area of tissue engineering concerns research into alternatives for new bone formation and replacing its function. Scaffolds have been developed to meet this requirement, allowing cell migration, bone tissue growth, transport of growth factors and nutrients, and the improvement of the mechanical properties of bone. Scaffolds are made from different biomaterials and manufactured using several techniques that, in some cases, do not allow full control over the size and orientation of the pores characterizing the scaffold. A novel hypothesis that a reaction–diffusion (RD) system can be used for designing the geometrical specifications of the bone matrix is thus presented here. The hypothesis was evaluated by making simulations in two- and three-dimensional RD systems in conjunction with the biomaterial scaffold. The results showed the methodology's effectiveness in controlling features such as the percentage of porosity, size, orientation, and interconnectivity of pores in an injectable bone matrix produced by the proposed hypothesis.

scholarly journals Printing bone in a gel: using nanocomposite bioink to print functionalised bone scaffolds

2019 ◽  
Vol 4 ◽  
pp. 100028 ◽  
Author(s):  
G. Cidonio ◽  
M. Cooke ◽  
M. Glinka ◽  
J.I. Dawson ◽  
L. Grover ◽  
...  
Keyword(s):  
Bone Scaffolds

Guided differentiation of bone marrow stromal cells on co-cultured cartilage and bone scaffolds

Soft Matter ◽  
2015 ◽  
Vol 11 (38) ◽  
pp. 7648-7655 ◽  
Author(s):  
Paul Lee ◽  
Katelyn Tran ◽  
Gan Zhou ◽  
Asheesh Bedi ◽  
Namdev B. Shelke ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Extracellular Matrix ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Bone Scaffolds ◽  
Extracellular Matrix Components ◽  
Matrix Components ◽  
Osteochondral Tissue ◽  
Tissue Material

A biphasic micro and nanostructured scaffold with hydroxyapatite and extracellular matrix components was created for the regeneration of osteochondral tissue. Material cues of the biphasic scaffold supported differentiation of bone marrow stromal cells in both osteogenic and chondrogenic lineages.

scholarly journals Additive manufacturing of PLA-based scaffolds intended for bone regeneration and strategies to improve their biological properties

e-Polymers ◽  
2020 ◽  
Vol 20 (1) ◽  
pp. 571-599
Author(s):  
Ricardo Donate ◽  
Mario Monzón ◽  
María Elena Alemán-Domínguez
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Bone Regeneration ◽  
Polylactic Acid ◽  
State Of The Art ◽  
Biological Properties ◽  
Design Stage ◽  
Bone Scaffolds ◽  
Regeneration Of Bone

AbstractPolylactic acid (PLA) is one of the most commonly used materials in the biomedical sector because of its processability, mechanical properties and biocompatibility. Among the different techniques that are feasible to process this biomaterial, additive manufacturing (AM) has gained attention recently, as it provides the possibility of tuning the design of the structures. This flexibility in the design stage allows the customization of the parts in order to optimize their use in the tissue engineering field. In the recent years, the application of PLA for the manufacture of bone scaffolds has been especially relevant, since numerous studies have proven the potential of this biomaterial for bone regeneration. This review contains a description of the specific requirements in the regeneration of bone and how the state of the art have tried to address them with different strategies to develop PLA-based scaffolds by AM techniques and with improved biofunctionality.

Piperazine-based polyurethane-ureas with controllable degradation as potential bone scaffolds

Polymer ◽  
2014 ◽  
Vol 55 (4) ◽  
pp. 1020-1027 ◽  
Author(s):  
Changshun Ruan ◽  
Nan Hu ◽  
Yang Hu ◽  
Lixin Jiang ◽  
Qingqing Cai ◽  
...  
Keyword(s):  
Bone Scaffolds ◽  
Controllable Degradation

scholarly journals Design of the Artificial Bone Scaffolds Based on the Multi-field Coupling Model

Procedia CIRP ◽  
2016 ◽  
Vol 56 ◽  
pp. 95-99 ◽  
Author(s):  
Xue Xing ◽  
Yao Chen ◽  
Xiu-Tian Yan ◽  
Guo-yuan Zhang
Keyword(s):  
Coupling Model ◽  
Artificial Bone ◽  
Field Coupling ◽  
Bone Scaffolds

scholarly journals Computed Tomographic Evaluation of Bone Quality of the Mandible Reconstructed by Particular Cellular Bone and Marrow Combined with Platelet Rich Plasma

2009 ◽  
Vol 6 (2) ◽  
pp. 63-72 ◽  
Author(s):  
Muneharu Iwamoto ◽  
Akira Matsuo ◽  
Noriko Kato ◽  
Sawako Takeuchi ◽  
Hidetoshi Takahashi ◽  
...  
Keyword(s):  
Bone Quality ◽  
Platelet Rich Plasma ◽  
Computed Tomographic ◽  
Cellular Bone
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