scholarly journals Neutrophils in Rheumatoid Arthritis: A Target for Discovering New Therapies Based on Natural Products

2017 ◽  
Author(s):  
Elaine Cruz Rosas ◽  
Luana Barbosa Correa ◽  
Maria das Graças Henriques
Keyword(s):  
Rheumatoid Arthritis ◽  
Natural Products ◽  
New Therapies

scholarly journals Chinese Herbal Medicines for Rheumatoid Arthritis: Text-Mining the Classical Literature for Potentially Effective Natural Products

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Xuan Xia ◽  
Brian H. May ◽  
Anthony Lin Zhang ◽  
Xinfeng Guo ◽  
Chuanjian Lu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Natural Products ◽  
Chinese Medicine ◽  
Text Mining ◽  
Experimental Investigations ◽  
Future Research ◽  
Classical Literature ◽  
Research Attention ◽  
New Therapies ◽  
Modern Chinese

Background. Rheumatoid arthritis (RA) is an autoimmune disease characterized by multijoint swelling, pain, and destruction of the synovial joints. Treatments are available but new therapies are still required. One source of new therapies is natural products, including herbs used in traditional medicines. In China and neighbouring countries, natural products have been used throughout recorded history and are still in use for RA and its symptoms. This study used text-mining of a database of classical Chinese medical books to identify candidates for future clinical and experimental investigations of therapeutics for RA. Methods. The database Encyclopaedia of Traditional Chinese Medicine (Zhong Hua Yi Dian) includes the full texts of over 1,150 classical books. Eight traditional terms were searched. All citations were assessed for relevance to RA. Results and Conclusions. After removal of duplications, 3,174 citations were considered. After applying the exclusion and inclusion criteria, 548 citations of traditional formulas were included. These derived from 138 books written from 206 CE to 1948. These formulas included 5,018 ingredients (mean, 9 ingredients/formula) comprising 243 different natural products. When these text-mining results were compared to the 18 formulas recommended in a modern Chinese Medicine clinical practice guideline, 44% of the herbal formulas were the same. This suggests considerable continuity in the clinical application of these herbs between classical and modern Chinese medicine practice. Of the 15 herbs most frequently used as ingredients of the classical formulas, all have received research attention, and all have been reported to have anti-inflammatory effects. Two of these 15 herbs have already been developed into new anti-RA therapeutics—sinomenine from Sinomenium acutum (Thunb.) Rehd. & Wils and total glucosides of peony from Paeonia lactiflora Pall. Nevertheless, there remains considerable scope for further research. This text-mining approach was effective in identifying multiple natural product candidates for future research.

scholarly journals New Therapies for Rheumatoid Arthritis

2003 ◽  
Vol 59 (2) ◽  
pp. 90-92 ◽  
Author(s):  
A Kumar ◽  
V Marwaha
Keyword(s):  
Rheumatoid Arthritis ◽  
New Therapies

Anti-inflammatory natural products as potential therapeutic agents of rheumatoid arthritis: A systematic review

Phytomedicine ◽  
2021 ◽  
pp. 153766
Author(s):  
Gopalsamy Rajiv Gandhi ◽  
Gnanasekaran Jothi ◽  
Thiruchenduran Mohana ◽  
Alan Bruno Silva Vasconcelos ◽  
Monalisa Martins Montalvão ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Natural Products ◽  
Therapeutic Agents ◽  
Anti Inflammatory

scholarly journals New therapies for rheumatoid arthritis

2005 ◽  
Vol 140 (2) ◽  
pp. 195-204 ◽  
Author(s):  
F. Goldblatt ◽  
D. A. Isenberg
Keyword(s):  
Rheumatoid Arthritis ◽  
New Therapies

New therapies for treatment of rheumatoid arthritis

The Lancet ◽  
2007 ◽  
Vol 370 (9602) ◽  
pp. 1861-1874 ◽  
Author(s):  
Josef S Smolen ◽  
Daniel Aletaha ◽  
Marcus Koeller ◽  
Michael H Weisman ◽  
Paul Emery
Keyword(s):  
Rheumatoid Arthritis ◽  
New Therapies

scholarly journals Isolation and Purification of a Cyclooxygenase-2 from the Blood of a Patient Suffering from Rheumatoid Arthritis and Studying the Effect of Natural Products of the Soapwort on the Activity of Purified Enzyme

2016 ◽  
Vol 13 (1) ◽  
pp. 133-145
Author(s):  
Baghdad Science Journal
Keyword(s):  
Rheumatoid Arthritis ◽  
Molecular Weight ◽  
Natural Products ◽  
Negative Impact ◽  
Polyacrylamide Gel Electrophoresis ◽  
Sodium Dodecyl ◽  
Cyclooxygenase 2 ◽  
Isolation And Purification ◽  
Rheumatoid Arthritis Disease ◽  
Approximate Molecular Weight

In this paper to isolate and study the properties of the cyclooxygenase-2 (EC: 1.14.99.1) enzyme in the blood of a patient suffering from rheumatoid arthritis and study the effect of natural products of the Soapwort on the activity of purified enzyme. The study involves taking 30 ml of blood from an adult woman 40 years old, who suffers from rheumatoid arthritis disease for 13 years. Serum is separated and subjected to a series of purification processes including: precipitation by ammonium sulfate, filtration by centrifugation radiator, dialysis in presence of ammonium bicarbonate, separation using the technology of ion exchange, lipholization and then estimating approximate molecular weight of the enzyme using gel filtration technique and sodium dodecyl sulfate (SDS)-page polyacrylamide gel electrophoresis. The study also includes isolating the natural products of Soapwort plant and study the effect of isolated natural products on the activity of the purified enzyme. The result of the study indicates that cycloxygenase-2 has an approximate molecular weight of 71.5 kDa and that the extracted oil of the Soapwort has a negative impact on the activity of the enzyme (r= -0.824; P=0.006), while flavonoids and Saponin have no such impact (r= -0.565; P=0.113; r= -0.634; P=0.067 respectively).

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