scholarly journals Chinese Herbal Medicines for Rheumatoid Arthritis: Text-Mining the Classical Literature for Potentially Effective Natural Products

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Xuan Xia ◽  
Brian H. May ◽  
Anthony Lin Zhang ◽  
Xinfeng Guo ◽  
Chuanjian Lu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Natural Products ◽  
Chinese Medicine ◽  
Text Mining ◽  
Experimental Investigations ◽  
Future Research ◽  
Classical Literature ◽  
Research Attention ◽  
New Therapies ◽  
Modern Chinese

Background. Rheumatoid arthritis (RA) is an autoimmune disease characterized by multijoint swelling, pain, and destruction of the synovial joints. Treatments are available but new therapies are still required. One source of new therapies is natural products, including herbs used in traditional medicines. In China and neighbouring countries, natural products have been used throughout recorded history and are still in use for RA and its symptoms. This study used text-mining of a database of classical Chinese medical books to identify candidates for future clinical and experimental investigations of therapeutics for RA. Methods. The database Encyclopaedia of Traditional Chinese Medicine (Zhong Hua Yi Dian) includes the full texts of over 1,150 classical books. Eight traditional terms were searched. All citations were assessed for relevance to RA. Results and Conclusions. After removal of duplications, 3,174 citations were considered. After applying the exclusion and inclusion criteria, 548 citations of traditional formulas were included. These derived from 138 books written from 206 CE to 1948. These formulas included 5,018 ingredients (mean, 9 ingredients/formula) comprising 243 different natural products. When these text-mining results were compared to the 18 formulas recommended in a modern Chinese Medicine clinical practice guideline, 44% of the herbal formulas were the same. This suggests considerable continuity in the clinical application of these herbs between classical and modern Chinese medicine practice. Of the 15 herbs most frequently used as ingredients of the classical formulas, all have received research attention, and all have been reported to have anti-inflammatory effects. Two of these 15 herbs have already been developed into new anti-RA therapeutics—sinomenine from Sinomenium acutum (Thunb.) Rehd. & Wils and total glucosides of peony from Paeonia lactiflora Pall. Nevertheless, there remains considerable scope for further research. This text-mining approach was effective in identifying multiple natural product candidates for future research.

scholarly journals Modern Perspectives of Curcumin and its Derivatives as Promising Bioactive and Pharmaceutical Agents

2021 ◽  
Vol 12 (6) ◽  
pp. 7177-7204
Keyword(s):  
Natural Products ◽  
Heart Disease ◽  
Chinese Medicine ◽  
Recent Progress ◽  
Curcuma Longa ◽  
Future Research ◽  
Positive Effects ◽  
Natural Product Research ◽  
Health Disorders ◽  
Pharmaceutical Agents

In the current era of eco-preservation, global research has focused on using raw and sustainable natural products with new clean technologies. New pharmaceutical or pharmaceutical agents from renewable sources are considered as essential as pure chemicals or certified fragments. A variety of natural phytoconstituents have been shown to reduce the risk of certain diseases and disorders, for example, diabetes, heart disease, cancer, neoplastic, and other health disorders. And, therefore, ongoing efforts to identify specific chemicals in these foods may contribute to their positive effects on beans/grains, fruits, vegetables, etc. Many of the phytochemicals that occurred as natural products in medicinal plants offer many opportunities in natural product research due to their versatile uses and various formulation. Curcuminoids are polyphenols found in the under-soil rhizome of Curcuma longa L. and have been used for centuries for spice, culinary, and food coloring purposes, and description also documented in the alternative system of medicines such as Indian Ayurveda, Sidha, Unani, and Chinese medicine system. It has been observed from the literature that the C. longa rhizome or commonly known as turmeric has several phytochemicals to possess anti-inflammatory, hepatoprotective, neuroprotective, antioxidant, anticancer, cardioprotective properties, and many more. The review highlights the recent progress of curcumin and its derivatives as promising bioactive and pharmaceutical agents with emphasis on future research dimensions required to propose curcuminoids as promising candidates for therapeutic and pharmacology-related sectors.

Chinese Medicine Protein and Peptide in Gene and Cell Therapy

2019 ◽  
Vol 20 (3) ◽  
pp. 251-264 ◽  
Author(s):  
Yinlu Feng ◽  
Zifei Yin ◽  
Daniel Zhang ◽  
Arun Srivastava ◽  
Chen Ling
Keyword(s):  
Chinese Medicine ◽  
Cell Therapy ◽  
Future Research ◽  
The Past ◽  
Promising Strategy ◽  
Wide Range ◽  
New Directions ◽  
Gene And Cell Therapy ◽  
Proteins And Peptides

The success of gene and cell therapy in clinic during the past two decades as well as our expanding ability to manipulate these biomaterials are leading to new therapeutic options for a wide range of inherited and acquired diseases. Combining conventional therapies with this emerging field is a promising strategy to treat those previously-thought untreatable diseases. Traditional Chinese medicine (TCM) has evolved for thousands of years in China and still plays an important role in human health. As part of the active ingredients of TCM, proteins and peptides have attracted long-term enthusiasm of researchers. More recently, they have been utilized in gene and cell therapy, resulting in promising novel strategies to treat both cancer and non-cancer diseases. This manuscript presents a critical review on this field, accompanied with perspectives on the challenges and new directions for future research in this emerging frontier.

scholarly journals Can neuroscience help to understand narcissism? A systematic review of an emerging field

2021 ◽  
Vol 4 ◽  
Author(s):  
Emanuel Jauk ◽  
Philipp Kanske
Keyword(s):  
Systematic Review ◽  
Stress Responses ◽  
Interpersonal Functioning ◽  
Integrative Model ◽  
Experimental Investigations ◽  
Future Research ◽  
Pathological Narcissism ◽  
Ego Threat ◽  
Self Reports ◽  
And Behavior

Abstract Narcissism is a Janusian personality construct, associated with both grandiose self-assuredness and dominance, as well as vulnerable insecurity and reactivity. Central questions of intra- and interpersonal functioning in narcissism are still a matter of debate. Neuroscience could help to understand the paradoxical patterns of experience and behavior beyond the limitations of self-reports. We provide a systematic review of 34 neuroscience studies on grandiose, vulnerable, pathological narcissism, and Narcissistic Personality Disorder (NPD), spanning experimental investigations of intra- and interpersonal mechanisms, research on neurophysiological and neuroendocrine aspects of baseline function, and brain structural correlates. While neuroscience has scarcely directly studied vulnerable narcissism, grandiose narcissism is associated with heightened vigilance to ego threat and stress responses following ego threat, as well as heightened stress indicators in baseline measures. Such responses are not commonly observed in self-reports, highlighting the potential of neuroscience to augment our understanding of self-regulatory dynamics in narcissism. Interpersonal functioning is characterized by deficits in social–affective processes. Both involve altered activity within the salience network, pointing to a double dissociation regarding the expression of narcissism and self/other oriented situational focus. Findings are summarized in an integrative model providing testable hypotheses for future research along with methodological recommendations.

scholarly journals Social exclusion increases the executive function of attention networks

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Huoyin Zhang ◽  
Shiyunmeng Zhang ◽  
Jiachen Lu ◽  
Yi Lei ◽  
Hong Li
Keyword(s):  
Social Exclusion ◽  
Executive Control ◽  
Brain Regions ◽  
Negative Influence ◽  
Future Research ◽  
Research Attention ◽  
Attention Network ◽  
Attention Networks ◽  
The Social ◽  
And Control

AbstractPrevious studies in humans have shown that brain regions activating social exclusion overlap with those related to attention. However, in the context of social exclusion, how does behavioral monitoring affect individual behavior? In this study, we used the Cyberball game to induce the social exclusion effect in a group of participants. To explore the influence of social exclusion on the attention network, we administered the Attention Network Test (ANT) and compared results for the three subsystems of the attention network (orienting, alerting, and executive control) between exclusion (N = 60) and inclusion (N = 60) groups. Compared with the inclusion group, the exclusion group showed shorter overall response time and better executive control performance, but no significant differences in orienting or alerting. The excluded individuals showed a stronger ability to detect and control conflicts. It appears that social exclusion does not always exert a negative influence on individuals. In future research, attention to network can be used as indicators of social exclusion. This may further reveal how social exclusion affects individuals' psychosomatic mechanisms.

scholarly journals Co-Creating New Directions for Service Robots in Hospitality and Tourism

2021 ◽  
Vol 2 (1) ◽  
pp. 43-61
Author(s):  
Francesc Fusté-Forné ◽  
Tazim Jamal
Keyword(s):  
Ethical Issues ◽  
Research Literature ◽  
Service Robots ◽  
Future Research ◽  
Research Attention ◽  
Research And Practice ◽  
Tourism Management ◽  
New Directions ◽  
Hospitality And Tourism ◽  
New Research

Research on the relationship between automation services and tourism has been rapidly growing in recent years and has led to a new service landscape where the role of robots is gaining both practical and research attention. This paper builds on previous reviews and undertakes a comprehensive analysis of the research literature to discuss opportunities and challenges presented by the use of service robots in hospitality and tourism. Management and ethical issues are identified and it is noted that practical and ethical issues (roboethics) continue to lack attention. Going forward, new directions are urgently needed to inform future research and practice. Legal and ethical issues must be proactively addressed, and new research paradigms developed to explore the posthumanist and transhumanist transitions that await. In addition, closer attention to the potential of “co-creation” for addressing innovations in enhanced service experiences in hospitality and tourism is merited. Among others, responsibility, inclusiveness and collaborative human-robot design and implementation emerge as important principles to guide future research and practice in this area.

scholarly journals Metabolomics study of the therapeutic mechanism of a Chinese herbal formula on collagen-induced arthritis mice

RSC Advances ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 3716-3725 ◽  
Author(s):  
Zhen Jin ◽  
Ji-da Zhang ◽  
Xin Wu ◽  
Gang Cao
Keyword(s):  
Rheumatoid Arthritis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Herbal Formula ◽  
Collagen Induced Arthritis ◽  
Chinese Herbal Formula ◽  
Chinese Herbal ◽  
Therapeutic Mechanism ◽  
Metabolomics Study

Wenjinghuoluo (WJHL) prescription, the typical rheumatoid arthritis (RA) treatment compound in traditional Chinese medicine, shows favorable efficacy.

scholarly journals IoT Cloud Security Review

2021 ◽  
Vol 54 (4) ◽  
pp. 1-36
Author(s):  
Fei Chen ◽  
Duming Luo ◽  
Tao Xiang ◽  
Ping Chen ◽  
Junfeng Fan ◽  
...  
Keyword(s):  
Case Studies ◽  
Service Providers ◽  
Risk Mitigation ◽  
Rapid Development ◽  
Security Analysis ◽  
Cloud Security ◽  
Future Research ◽  
Security Risk ◽  
Research Attention ◽  
Cloud Systems

Recent years have seen the rapid development and integration of the Internet of Things (IoT) and cloud computing. The market is providing various consumer-oriented smart IoT devices; the mainstream cloud service providers are building their software stacks to support IoT services. With this emerging trend even growing, the security of such smart IoT cloud systems has drawn much research attention in recent years. To better understand the emerging consumer-oriented smart IoT cloud systems for practical engineers and new researchers, this article presents a review of the most recent research efforts on existing, real, already deployed consumer-oriented IoT cloud applications in the past five years using typical case studies. Specifically, we first present a general model for the IoT cloud ecosystem. Then, using the model, we review and summarize recent, representative research works on emerging smart IoT cloud system security using 10 detailed case studies, with the aim that the case studies together provide insights into the insecurity of current emerging IoT cloud systems. We further present a systematic approach to conduct a security analysis for IoT cloud systems. Based on the proposed security analysis approach, we review and suggest potential security risk mitigation methods to protect IoT cloud systems. We also discuss future research challenges for the IoT cloud security area.

Sign in / Sign up

Export Citation Format

Share Document