scholarly journals The Role of Current Techniques and Concepts in Peripheral Nerve Repair

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
K. S. Houschyar ◽  
A. Momeni ◽  
M. N. Pyles ◽  
J. Y. Cha ◽  
Z. N. Maan ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Clinical Application ◽  
Functional Recovery ◽  
Nerve Repair ◽  
Treatment Options ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
Peripheral Nerve Repair

Patients with peripheral nerve injuries, especially severe injury, often face poor nerve regeneration and incomplete functional recovery, even after surgical nerve repair. This review summarizes treatment options of peripheral nerve injuries with current techniques and concepts and reviews developments in research and clinical application of these therapies.

scholarly journals Recent Findings on the Effects of Pharmacological Agents on the Nerve Regeneration after Peripheral Nerve Injury

2020 ◽  
Vol 18 (11) ◽  
pp. 1154-1163
Author(s):  
Samira Bolandghamat ◽  
Morteza Behnam-Rassouli
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Nerve Injury ◽  
Molecular Mechanisms ◽  
Functional Disability ◽  
Nerve Repair ◽  
Invasive Treatment ◽  
Pharmacological Agents ◽  
Non Invasive ◽  
Repair Techniques

: Peripheral nerve injuries (PNIs) are accompanied with neuropathic pain and functional disability. Despite improvements in surgical repair techniques in recent years, the functional recovery is yet unsatisfied. Indeed a successful nerve repair depends not only on the surgical strategy but also on the cellular and molecular mechanisms involved in traumatic nerve injury. In contrast to all strategies suggested for nerve repair, pharmacotherapy is a cheap, accessible and non-invasive treatment that can be used immediately after nerve injury. This study aimed to review the effects of some pharmacological agents on the nerve regeneration after traumatic PNI evaluated by functional, histological and electrophysiological assessments. In addition, some cellular and molecular mechanisms responsible for their therapeutic actions, restricted to neural tissue, are suggested. These findings can not only help to find better strategies for peripheral nerve repair, but also to identify the neuropathic effects of various medications and their mechanisms of action.

Biologic Strategies to Improve Nerve Regeneration after Peripheral Nerve Repair

2014 ◽  
Vol 31 (04) ◽  
pp. 243-248 ◽  
Author(s):  
Mitra Lavasani ◽  
Johnny Huard ◽  
Robert Goitz ◽  
John Fowler
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Nerve Repair ◽  
Peripheral Nerve Repair

scholarly journals Strategies for Peripheral Nerve Repair

2020 ◽  
Vol 1 (2) ◽  
pp. 49-59 ◽  
Author(s):  
Matthew Wilcox ◽  
Holly Gregory ◽  
Rebecca Powell ◽  
Tom J. Quick ◽  
James B. Phillips
Keyword(s):  
Clinical Outcome ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Nerve Repair ◽  
Clinical Use ◽  
Peripheral Nerve Repair ◽  
Tissue Microenvironment ◽  
Engineered Tissues ◽  
Mechanical Factors ◽  
Clinical Measures

Abstract Purpose of Review This review focuses on biomechanical and cellular considerations required for development of biomaterials and engineered tissues suitable for implantation following PNI, as well as translational requirements relating to outcome measurements for testing success in patients. Recent Findings Therapies that incorporate multiple aspects of the regenerative environment are likely to be key to improving therapies for nerve regeneration. This represents a complex challenge when considering the diversity of biological, chemical and mechanical factors involved. In addition, clinical outcome measures following peripheral nerve repair which are sensitive and responsive to changes in the tissue microenvironment following neural injury and regeneration are required. Summary Effective new therapies for the treatment of PNI are likely to include engineered tissues and biomaterials able to evoke a tissue microenvironment that incorporates both biochemical and mechanical features supportive to regeneration. Translational development of these technologies towards clinical use in humans drives a concomitant need for improved clinical measures to quantify nerve regeneration.

The Role of Chondroitinase as an Adjuvant to Peripheral Nerve Repair

2015 ◽  
Vol 200 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Trenton M. Gause II ◽  
Wesley N. Sivak ◽  
Kacey G. Marra
Keyword(s):  
Peripheral Nerve ◽  
Nerve Repair ◽  
Peripheral Nerve Repair

The Role of Magnesium Biodegradable Material in Peripheral Nerve Repair

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Lubna F. Abu-Niaaj ◽  
Greg Harris ◽  
Sarah Pixley
Keyword(s):  
Peripheral Nerve ◽  
Nerve Repair ◽  
Biodegradable Material ◽  
Peripheral Nerve Repair

The role of botulinum toxin type a-induced motor endplates after peripheral nerve repair

2015 ◽  
Vol 52 (3) ◽  
pp. 412-418 ◽  
Author(s):  
Zeynep D. Akdeniz ◽  
Mehmet Bayramiçli ◽  
Filiz Ateş ◽  
Naziye Özkan ◽  
Can A. Yucesoy ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Peripheral Nerve ◽  
Nerve Repair ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Peripheral Nerve Repair ◽  
Motor Endplates
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