scholarly journals The Role of Current Techniques and Concepts in Peripheral Nerve Repair

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
K. S. Houschyar ◽  
A. Momeni ◽  
M. N. Pyles ◽  
J. Y. Cha ◽  
Z. N. Maan ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Clinical Application ◽  
Functional Recovery ◽  
Nerve Repair ◽  
Treatment Options ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
Peripheral Nerve Repair

Patients with peripheral nerve injuries, especially severe injury, often face poor nerve regeneration and incomplete functional recovery, even after surgical nerve repair. This review summarizes treatment options of peripheral nerve injuries with current techniques and concepts and reviews developments in research and clinical application of these therapies.

Use of electrospinning to construct biomaterials for peripheral nerve regeneration

2016 ◽  
Vol 27 (7) ◽  
pp. 761-768 ◽  
Author(s):  
Qi Quan ◽  
Biao Chang ◽  
Hao Ye Meng ◽  
Ruo Xi Liu ◽  
Yu Wang ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Functional Recovery ◽  
Nerve Repair ◽  
Peripheral Nerve Regeneration ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
New Process ◽  
Recent Developments ◽  
Innovative Techniques

AbstractA number of limitations associated with the use of hollow nerve guidance conduits (NGCs) require further discussion. Most importantly, the functional recovery outcomes after the placement of hollow NGCs are poor even after the successful bridging of peripheral nerve injuries. However, nerve regeneration scaffolds built using electric spinning have several advantages that may improve functional recovery. Thus, the present study summarizes recent developments in this area, including the key cells that are combined with the scaffold and associated with nerve regeneration, the structure and configuration of the electrospinning design (which determines the performance of the electrospinning scaffold), the materials the electrospinning fibers are composed of, and the methods used to control the morphology of a single fiber. Additionally, this study also discusses the processes underlying peripheral nerve regeneration. The primary goals of the present review were to evaluate and consolidate the findings of studies that used scaffolding biomaterials built by electrospinning used for peripheral nerve regeneration support. It is amazing that the field of peripheral nerve regeneration continues to consistently produce such a wide variety of innovative techniques and novel types of equipment, because the introduction of every new process creates an opportunity for advances in materials for nerve repair.

Fabrication and Radial Compressive Properties of the Biodegradable Woven Regeneration Conduits for Peripheral Nerve Repair

2011 ◽  
Vol 332-334 ◽  
pp. 1481-1484 ◽  
Author(s):  
Chang Kun Ding ◽  
Xing Feng Guo ◽  
Bo Wen Cheng ◽  
Qiong Wu
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Functional Recovery ◽  
Nerve Repair ◽  
Mechanical Compression ◽  
Compressive Properties ◽  
Peripheral Nerve Repair ◽  
Potential Applications ◽  
Biodegradable Poly ◽  
Fabric Structures

Novel regeneration conduits woven from biodegradable poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) fibers for peripheral nerve repair and their radial compressive properties are presented. The influence of the fabric structures was discussed. The results showed that the 1/3 weave has a higher ability to resist the mechanical compression than the 3/1 weave. The woven conduits have potential applications in nerve regeneration and improving peripheral nerve functional recovery.

scholarly journals Modelling-informed cell-seeded nerve repair construct designs for treating peripheral nerve injuries

2021 ◽  
Vol 17 (7) ◽  
pp. e1009142
Author(s):  
Rachel Coy ◽  
Maxime Berg ◽  
James B. Phillips ◽  
Rebecca J. Shipley
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Functional Recovery ◽  
Nerve Tissue ◽  
Diffusion Reaction ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
Linear Diffusion ◽  
Wide Range

Millions of people worldwide are affected by peripheral nerve injuries (PNI), involving billions of dollars in healthcare costs. Common outcomes for patients include paralysis and loss of sensation, often leading to lifelong pain and disability. Engineered Neural Tissue (EngNT) is being developed as an alternative to the current treatments for large-gap PNIs that show underwhelming functional recovery in many cases. EngNT repair constructs are composed of a stabilised hydrogel cylinder, surrounded by a sheath of material, to mimic the properties of nerve tissue. The technology also enables the spatial seeding of therapeutic cells in the hydrogel to promote nerve regeneration. The identification of mechanisms leading to maximal nerve regeneration and to functional recovery is a central challenge in the design of EngNT repair constructs. Using in vivo experiments in isolation is costly and time-consuming, offering a limited insight on the mechanisms underlying the performance of a given repair construct. To bridge this gap, we derive a cell-solute model and apply it to the case of EngNT repair constructs seeded with therapeutic cells which produce vascular endothelial growth factor (VEGF) under low oxygen conditions to promote vascularisation in the construct. The model comprises a set of coupled non-linear diffusion-reaction equations describing the evolving cell population along with its interactions with oxygen and VEGF fields during the first 24h after transplant into the nerve injury site. This model allows us to evaluate a wide range of repair construct designs (e.g. cell-seeding strategy, sheath material, culture conditions), the idea being that designs performing well over a short timescale could be shortlisted for in vivo trials. In particular, our results suggest that seeding cells beyond a certain density threshold is detrimental regardless of the situation considered, opening new avenues for future nerve tissue engineering.

Biologic Strategies to Improve Nerve Regeneration after Peripheral Nerve Repair

2014 ◽  
Vol 31 (04) ◽  
pp. 243-248 ◽  
Author(s):  
Mitra Lavasani ◽  
Johnny Huard ◽  
Robert Goitz ◽  
John Fowler
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Nerve Repair ◽  
Peripheral Nerve Repair

scholarly journals Strategies for Peripheral Nerve Repair

2020 ◽  
Vol 1 (2) ◽  
pp. 49-59 ◽  
Author(s):  
Matthew Wilcox ◽  
Holly Gregory ◽  
Rebecca Powell ◽  
Tom J. Quick ◽  
James B. Phillips
Keyword(s):  
Clinical Outcome ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Nerve Repair ◽  
Clinical Use ◽  
Peripheral Nerve Repair ◽  
Tissue Microenvironment ◽  
Engineered Tissues ◽  
Mechanical Factors ◽  
Clinical Measures

Abstract Purpose of Review This review focuses on biomechanical and cellular considerations required for development of biomaterials and engineered tissues suitable for implantation following PNI, as well as translational requirements relating to outcome measurements for testing success in patients. Recent Findings Therapies that incorporate multiple aspects of the regenerative environment are likely to be key to improving therapies for nerve regeneration. This represents a complex challenge when considering the diversity of biological, chemical and mechanical factors involved. In addition, clinical outcome measures following peripheral nerve repair which are sensitive and responsive to changes in the tissue microenvironment following neural injury and regeneration are required. Summary Effective new therapies for the treatment of PNI are likely to include engineered tissues and biomaterials able to evoke a tissue microenvironment that incorporates both biochemical and mechanical features supportive to regeneration. Translational development of these technologies towards clinical use in humans drives a concomitant need for improved clinical measures to quantify nerve regeneration.

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