scholarly journals Are ABO Gene Alleles Responsible for Cardiovascular Diseases and Venous Thromboembolism and Do They Play a Role in COVID?

2021 ◽  
Author(s):  
Dennis J. Cordato ◽  
Wissam Soubra ◽  
Sameer Saleem ◽  
Kaneez Fatima Shad
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Venous Thromboembolism ◽  
Cardiovascular Diseases ◽  
Factor Viii ◽  
Blood Group ◽  
Blood Groups ◽  
Group Type ◽  
Blood Group Type ◽  
Peripheral Arterial

Cardiovascular diseases (CVD) including coronary heart disease and stroke are leading causes of death and disability globally. Studies of the association between ABO blood groups and CVD have consistently demonstrated an increased risk of coronary heart disease, myocardial infarction, cerebral ischaemic stroke, peripheral arterial disease and venous thromboembolism (VTE) including deep vein thrombosis and pulmonary thromboembolism in patients who possess a non-O blood group type. The most likely mechanism is thought to be the increase in von Willebrand Factor (vWF) and factor VIII levels seen in patients with a non-O blood group. Other postulated mechanisms include elevations in circulating inflammatory markers such as endothelial cell and platelet adhesion molecules in subjects with a non-O blood group. More recently, it has also been recognised that individuals with a non-O blood group type carry a higher risk of SARS-C0V-2 infection and COVID-19 related complications. The increased levels in vWF and factor VIII amongst individuals with a non-O blood group who have contracted SARS-CoV-2 infection may result in an additive thrombophilic effect to that caused by the SARS-CoV-2 virus. Another postulated mechanism is that individuals with an O-blood group are protected by anti-A and B antibodies which possibly inhibit the binding of the SARS-CoV-2 spike protein to lung epithelium angiotensin converting enzyme-2 receptors. There are over 35 minor blood groups on red blood cells, some of which such as Kidd, Lewis and Duffy have been associated with CVD either alone or in combination with a non-O blood group allele(s). However, their role in SARS-CoV-2 infection and mechanism of action for an association with CVD remain unknown. This review explores the relationship between ABO and minor blood groups with CVD and VTE, with a focus on potential mechanisms underlying this relationship and the potential role of ABO blood group types in COVID.

“ASSOCIATION OF ABO & RH BLOOD GROUPS WITH HEPATITIS, HIV AND SYPHILIS INFECTIONS IN HEALTHY BLOOD DONORS AT TERTIARY CARE CENTRE”.

2021 ◽  
pp. 68-70
Author(s):  
Sonal Chitroda ◽  
Neha Patel ◽  
Pinal Solanki
Keyword(s):  
Blood Group ◽  
Blood Donors ◽  
Tertiary Care ◽  
Blood Groups ◽  
Care Hospital ◽  
Tertiary Care Centre ◽  
Group Type ◽  
Increased Risk ◽  
High Prevalence ◽  
Blood Group Type

Background: People from certain blood groups are more prone to develop infections transmitted by blood transfusion. In order to improve the management of such infections some hypothesis suggests that genetic predispositions like ABO and Rh blood groups would inuence the occurrence of such infections. Hence the present study aims to assess any possible associations of ABO & Rh blood groups with Hepatitis, HIV & syphilis infections in healthy blood donors. This was a retrospective study in heal Methods: thy blood donors of tertiary care hospital enrolled during years 2016 to 2020. Blood samples from total 34015 donors were screened for blood grouping & serology of HIV, Hepatitis & Syphilis. Result: Out of total donors only 171 donors were found positive for transfusion transmitted infections. Hepatitis B virus was found more prevalent compared to other infections. In ABO blood group type “B” and in Rh blood group type “Positive” was found more prevalent in donors. But it did not show any signicant association with transfusion transmitted infections. Conclusion: High prevalence of HBV infections in blood donors in present study point towards need of public health measures in general population. Undertaking further research to determine the special blood groups as increased risk for categorized donors is recommended.

scholarly journals Distribution of ABO Blood Group and Major Cardiovascular Risk Factors with Coronary Heart Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Santanu Biswas ◽  
Pradip K. Ghoshal ◽  
Bhubaneswar Halder ◽  
Nripendranath Mandal
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Blood Group ◽  
Blood Groups ◽  
Control Group ◽  
Abo Blood Group ◽  
Healthy Controls

The purpose of this study is to establish whether ABO blood group is related to coronary heart disease in an individual in Asian Indian Bengali population of eastern part of India. Two hundred and fifty (250) CHD patients and two hundred and fifty (250) age and sex matched healthy subjects were enrolled in the study. ABO blood group distribution in patients was compared with control group. Frequency of major cardiac risk factors was determined to find any correlation between blood groups and cardiovascular risk factors. The distribution of ABO blood groups in patients versus control group was A in 24.00 versus 21.60%, B in 30.80 versus 32.40%, O in 38.40 versus 21.60%, and AB in 6.80 versus 24.40%. The analysis showed significant difference in frequency of O (OR = 1.857, 95%CI = 1.112–3.100,P=0.018) and AB (OR = 0.447, 95%CI = 0.227–0.882,P=0.020) blood group between healthy controls and CHD individuals. Our results may suggest that the AB blood group decreases the risk of CHD in healthy controls, and it might be due to the higher concentration of high density lipoprotein cholesterol (HDL-c), while the O blood group increases the risk of CHD due to lower HDL-c levels in Bengali population of eastern part of India.

The Relation between the Blood Groups, Rhesus Factor, and Breast Cancer in the Holy Karbala Governorate

2020 ◽  
pp. 31-33
Keyword(s):  
Breast Cancer ◽  
Blood Group ◽  
Type A ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
Group Type ◽  
Rhesus Factor ◽  
Significant Difference ◽  
Healthy Control ◽  
Blood Group Type

The distribution ABO blood groups among patients with breast cancer were as follow: blood group type O (40.8%), blood group type A (25.0%), B (23.7%), and AB (10.4%), for the donor’s healthy control, ABO blood groups percentages were as follow: type O (39.9%) type A (28.1%), type B (22.0%), and type AB (9.9%). There is no significant association between blood types ABO and the breast cancer. (P > 0.05) Rh factor has a significant difference between patients with breast cancer and healthy control (P=0.002). There were significant differences in age categories among patients with breast cancer and controls. (p= 0.000) .

scholarly journals ABO and Rh blood groups, demographics, and comorbidities in COVID-19 related deaths: a retrospective study in Split-Dalmatia County, Croatia

2021 ◽  
Author(s):  
Ivan Brdar ◽  
Ivan Jerković ◽  
Željana Bašić ◽  
Nenad Kunac ◽  
Deny Anđelinović ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Retrospective Study ◽  
Blood Group ◽  
Protective Factor ◽  
Blood Groups ◽  
University Hospital ◽  
Older Individuals ◽  
Risk Of Death ◽  
Digestive Disorder

Aim: To examine ABO and Rh blood group distribution in COVID-19 related deaths considering demographics and pathological conditions. Materials and Methods: We conducted a retrospective study at the University Hospital Centre Split, Croatia, that included 245 COVID-positive individuals that died from April 8, 2020, to January 25, 2021. From the hospital database, we extracted data on their blood groups, demographics, and pre-existing comorbidities. To compare findings with the general population, we used information from collected blood group donations (n = 101357) and statistical reports of non-COVID deaths from 2019 (n = 4968). Results: The proportion of males was significantly higher in analyzed subjects than in non-COVID deaths from 2019 (63.7% vs. 48.9%, P < 0.001), while the proportion of older individuals did not differ (P = 0.8). The most common pre-existing diseases were hypertension (59.6%), diabetes (37.1%), heart failure (28.8%), digestive disorder (26.5%), and solid tumor (21.6%). The ABO distribution in the deceased and donors' group showed statistically significant differences, with the higher prevalence of A/AB group and lower prevalence of 0, but with individual differences significant only for AB and non-AB groups. There was a significantly reduced proportion of females within the deceased with group 0 (P = 0.014) and a higher proportion of AB individuals with coronary heart disease (P = 0.024), while other differences were not significant. Conclusion: The study confirmed a higher risk of death in male individuals. The lower proportion of type 0 in deceased individuals was more pronounced in females, implying that group 0 is not necessarily an independent protective factor. Among analyzed comorbidities, coronary heart disease was identified as a potential risk factor for AB individuals.

scholarly journals Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal

2012 ◽  
Vol 6 (10) ◽  
pp. 727-733 ◽  
Author(s):  
Aida Sadikh Badiane ◽  
Ousmane Sarr ◽  
Awa Bineta Deme ◽  
Ambroise Dioum Ahouidi ◽  
Papa Elhadji Omar Gueye ◽  
...  
Keyword(s):  
Blood Group ◽  
Plasmodium Falciparum Malaria ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
Blood Samples ◽  
Group Type ◽  
Erythrocyte Binding ◽  
Blood Group Type ◽  
First Time ◽  
Uncomplicated Plasmodium Falciparum Malaria

Introduction: The study was conducted to determine for the first time the association between the erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in malaria patients living in Thies, a hypoendemic area in Senegal. Methodology: In 2007, the EBA-175 alleles and blood group types were determined by nested PCR and the Simonin test respectively in blood samples obtained from uncomplicated Plasmodium falciparum malaria positive patients. Results and conclusion: In total, 129 patients were enrolled in the study. The EBA-175 genotyping showed a prevalence of 67.45% for the F-allele, 27.90% for the C-allele and 4.65% of mixed C+F infection. The distribution of the ABO blood group type showed 59.8% for the O group, 19.7% for the A group, 17.2% for the B group, and 3.3% for the AB group. No correlation was noted between the EBA-175 alleles and either the blood group type or parasitemia.

Abo and Rh blood groups in patients with coronary heart disease

1969 ◽  
Vol 2 (3) ◽  
pp. 105-108 ◽  
Author(s):  
Brian Maurer ◽  
Noel Hickey ◽  
Risteard Mulcahy
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Blood Groups

Prediction of atherosclerosis in children and the possibility of early prevention of coronary heart disease

1999 ◽  
Vol 80 (4) ◽  
pp. 296-297
Author(s):  
O. I. Pikuza ◽  
V. N. Oslopov ◽  
H. M. Vakhitov ◽  
A. A. Babushkina ◽  
S. E. Nikolsky
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Cardiovascular Diseases ◽  
Childhood And Adolescence ◽  
Early Prevention ◽  
Cerebrovascular Pathology ◽  
Artery Disease

Cardiovascular diseases caused by atherosclerosis (coronary artery disease, cerebrovascular pathology, etc.) are responsible for 40-50% of all deaths in adults. Of particular concern to clinicians is the emerging unfavorable tendency to "rejuvenate" these diseases. Currently, the fact that atherosclerosis (AS) begins to form in childhood and adolescence is indisputable.

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