scholarly journals Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

2021 ◽  
Author(s):  
Felipe Ocampo Osorio ◽  
Jhon Augusto Jativa Herrera ◽  
Oscar Moscoso Londoño ◽  
César Leandro Londoño Calderón
Keyword(s):  
Drug Delivery ◽  
The Body ◽  
Target Cells ◽  
Future Perspectives ◽  
Cancer Treatments ◽  
Area Of Interest ◽  
Nanostructured Systems ◽  
Drug Delivery Applications ◽  
Therapeutic Substance ◽  
Low Solubility

Cancer is the second cause of death worldwide, whose treatment often involves chemotherapy. In a conventional therapy, drug is transported (and usually absorbed) across biological membranes through diffusion and systemic transport. The pathway that medicine must travel before reaching the desired location, can bring adverse or unwanted effects, which are mainly the result of: low bioavailability, low solubility and toxicity. To avoiding risks, nanoparticles coated with the drug could be used as a therapeutic substance to selectively reach an area of interest to act without affecting non-target cells, organs, or tissues (drug delivery). Here, the goal is to enhance the concentration of the chemotherapeutic drug in the disease parts of the body. Among all nanostructured systems, ferrites attract worldwide attention in drug delivery applications. It is due to their versatile magnetic and physicochemical properties. Here, it is reviewed and analyzed recent advances in synthesis, morphology, size, magnetic properties, functionalization with a focus in drug delivery applications of nanoferrites.

Nanomaterials for Targeted Delivery of Anticancer Drugs: An Overview

2021 ◽  
Vol 06 ◽  
Author(s):  
Bhavna Choudhary ◽  
Pubalee Sarmah
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Chemotherapeutic Agents ◽  
Cancer Drug ◽  
Cancer Treatments ◽  
Area Of Interest ◽  
Efficient Delivery ◽  
Delivery Vehicles ◽  
Materials Used ◽  
Developing Area

: Application of nanomaterials in drug delivery is a rapidly developing area of interest. The main intention in the development of these drug delivery vehicles is to successfully know the targeted delivery-related efforts and carrying drugs to the required sites of therapeutic action with reduction in adverse side effects. The task for targeted drug delivery to reach pathological are-as has increased advances in nanomedicine. But the high toxicity of uncoated nanoparticles restricts the use in humans. So, to reduce toxicity, the encapsulation of nanoparticles is done with bio compatible materials. There are many efficient delivery systems thathave been developed in which nanoparticles are loaded with the cancer drug involvingbi-layer molecules. The fields of nanotechnology has always played a crucial role in electronics, biology and medicine. Its application can be ap-praised, as it involves the materials to be designed at atomic and molecular level.This article reviews different types of nano- materials used as delivery vehicles for chemotherapeutic agents and their mechanism of action that improve the therapeutic efficacy of the drugs. The recent scientific advances in the area of chemotherapy are also discussed with emphasizingthe fu-ture prospects in cancer treatments.

scholarly journals Understanding the Factors Influencing Chitosan-Based Nanoparticles-Protein Corona Interaction and Drug Delivery Applications

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4758
Author(s):  
Cristina Moraru ◽  
Manuela Mincea ◽  
Gheorghita Menghiu ◽  
Vasile Ostafe
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Biological Fluids ◽  
Chemical Properties ◽  
Protein Corona ◽  
Target Cells ◽  
Major Application ◽  
Targeted Drug ◽  
Drug Delivery Applications

Chitosan is a polymer that is extensively used to prepare nanoparticles (NPs) with tailored properties for applications in many fields of human activities. Among them, targeted drug delivery, especially when cancer therapy is the main interest, is a major application of chitosan-based NPs. Due to its positive charges, chitosan is used to produce the core of the NPs or to cover NPs made from other types of polymers, both strategies aiming to protect the carried drug until NPs reach the target sites and to facilitate the uptake and drug delivery into these cells. A major challenge in the design of these chitosan-based NPs is the formation of a protein corona (PC) upon contact with biological fluids. The composition of the PC can, to some extent, be modulated depending on the size, shape, electrical charge and hydrophobic/hydrophilic characteristics of the NPs. According to the composition of the biological fluids that have to be crossed during the journey of the drug-loaded NPs towards the target cells, the surface of these particles can be changed by covering their core with various types of polymers or with functionalized polymers carrying some special molecules, that will preferentially adsorb some proteins in their PC. The PC’s composition may change by continuous processes of adsorption and desorption, depending on the affinity of these proteins for the chemical structure of the surface of NPs. Beside these, in designing the targeted drug delivery NPs one can take into account their toxicity, initiation of an immune response, participation (enhancement or inhibition) in certain metabolic pathways or chemical processes like reactive oxygen species, type of endocytosis of target cells, and many others. There are cases in which these processes seem to require antagonistic properties of nanoparticles. Products that show good behavior in cell cultures may lead to poor in vivo results, when the composition of the formed PC is totally different. This paper reviews the physico-chemical properties, cellular uptake and drug delivery applications of chitosan-based nanoparticles, specifying the factors that contribute to the success of the targeted drug delivery. Furthermore, we highlight the role of the protein corona formed around the NP in its intercellular fate.

scholarly journals Stimulus-responsive liposomes as smart nanoplatforms for drug delivery applications

2018 ◽  
Vol 7 (1) ◽  
pp. 95-122 ◽  
Author(s):  
Parham Sahandi Zangabad ◽  
Soroush Mirkiani ◽  
Shayan Shahsavari ◽  
Behrad Masoudi ◽  
Maryam Masroor ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Target Cells ◽  
Stimulus Responsive ◽  
Different Types ◽  
Drug Delivery Applications ◽  
The Individual ◽  
Chemical Groups ◽  
External Stimuli ◽  
Toxic Drugs ◽  
Modification Of The Surface

AbstractLiposomes are known to be promising nanoparticles (NPs) for drug delivery applications. Among the different types of self-assembled NPs, liposomes stand out for their non-toxic nature and their possession of dual hydrophilic-hydrophobic domains. The advantages of liposomes include the ability to solubilize hydrophobic drugs, the ability to incorporate different hydrophilic and lipophilic drugs at the same time, lessening the exposure of host organs to potentially toxic drugs and allowing modification of the surface by a variety of different chemical groups. This modification of the surface, or of the individual constituents, may be used to achieve two important goals. First, ligands for active targeting can be attached that are recognized by cognate receptors overexpressed on the target cells of tissues. Second, modification can be used to impart a stimulus-responsive or “smart” character to the liposomes, whereby the cargo is released on demand only when certain internal stimuli (pH, reducing agents, specific enzymes) or external stimuli [light, magnetic field, or ultrasound (US)] are present. Here, we review the field of smart liposomes for drug delivery applications.

scholarly journals Bioinformatics Study Applied to the Pharmacokinetic Profile of Chitosan and its Derivatives with Biomedical Applicability

2020 ◽  
Vol 71 (6) ◽  
pp. 261-266
Author(s):  
Natalia Guma ◽  
Andreea Nastase ◽  
Marilena Motoc ◽  
Speranta Avram
Keyword(s):  
Drug Delivery ◽  
Nervous System ◽  
Drug Delivery System ◽  
Pharmacokinetic Profile ◽  
The Body ◽  
Administration System ◽  
Pharmacokinetic Profiles ◽  
Acetyl Group ◽  
Bioinformatics Study ◽  
Low Solubility

The N-acetyl group attached to monomeric glucosamine monomer units of chitin confers an extremely low solubility, which makes chitin difficult to process and therefore limiting its medical potential. In order to be used as a drug administration system in the body, it is important to know about the pharmacokinetic profiles of chitosan and its derivatives, more specifically about ADME-Tox profiles (absorption, distribution, metabolism, excretion, and toxicology). Through cheminformatics and bioinformatics tools, ADMET is identifying, a set of pharmacokinetic characteristics, such as absorption, distribution, metabolism, blood-brain barrier, nervous system barrier, and toxicological characteristics of chitosan and 5 of its derivatives. Our results have shown that one can try to integrate the drug delivery system into the body.

Orally Administered Nanotherapeutics For Parkinson’s Disease: An Old Delivery System Yet More Acceptable

2020 ◽  
Vol 26 (19) ◽  
pp. 2280-2290 ◽  
Author(s):  
Nidhi Aggarwal ◽  
Zufika Qamar ◽  
Saleha Rehman ◽  
Sanjula Baboota ◽  
Javed Ali
Keyword(s):  
Parkinson’S Disease ◽  
Drug Delivery ◽  
Parkinson's Disease ◽  
Drug Delivery Systems ◽  
Neurodegenerative Disorder ◽  
Intestinal Barrier ◽  
Oral Route ◽  
Delivery Systems ◽  
The Body ◽  
Area Of Interest

As per the present global scenario, Parkinson’s disease (PD) is considered to be the second most common neurodegenerative disorder which is a keen area of interest among researchers. The conventional therapies generally employed against PD are associated with serious drawbacks including limited transport across selectively permeable BBB, hepatic metabolism, intestinal barrier, etc. This urges the need to develop novel therapeutic alternatives. The oral route being the most preferred route of administration needs to be explored for new and more intelligent drug delivery systems. Nanotechnology has been proposed to play a promising role in reversing the progression of the disease via the oral route. Nanocarriers, namely nanoparticles, lipid nanoparticles, nanoemulsions, nanocrystals, nanomicellar formulations, self-nanoemulsifying drug delivery systems and alginate nanocomposites have been investigated upon to modulate the fate of drugs inside the human body when administered orally. The development of various nanotherapeutics for the treatment of PD has been reviewed, depicting an enhanced bioavailability to provide a desired therapeutic outcome. The new advances in the therapy have been explored and highlighted through the body of this review. However, a therapeutically effective concentration at the target site remains a challenge, therefore extensive exploration in the field of nanotherapeutics may facilitate superior drug delivery to CNS via oral route thereby improving the state of disease progression.

scholarly journals Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy

Nanomaterials ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 656 ◽  
Author(s):  
Rafael Contreras-Cáceres ◽  
Laura Cabeza ◽  
Gloria Perazzoli ◽  
Amelia Díaz ◽  
Juan Manuel López-Romero ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Electrospun Nanofibers ◽  
Poly Lactic Acid ◽  
Colloidal Nanoparticles ◽  
Stimuli Responsive ◽  
Cancer Treatments ◽  
Polymeric Nanofibers ◽  
Drug Delivery Applications ◽  
New Strategies

Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the encapsulation of antitumor drugs for controlled drug delivery applications, scaffolds structures for tissue engineering and regenerative medicine, as well as magnetic or plasmonic hyperthermia to be applied in the reduction of cancer tumors. This makes NFs useful as therapeutic implantable patches or mats to be implemented in numerous biomedical researching fields. In this context, several biocompatible polymers with excellent biocompatibility and biodegradability including poly lactic-co-glycolic acid (PLGA), poly butylcyanoacrylate (PBCA), poly ethylenglycol (PEG), poly (ε-caprolactone) (PCL) or poly lactic acid (PLA) have been widely used for the synthesis of NFs using the electrospun technique. Indeed, other types of polymers with stimuli-responsive capabilities has have recently reported for the fabrication of polymeric NFs scaffolds with relevant biomedical applications. Importantly, colloidal nanoparticles used as nanocarriers and non-biodegradable structures have been also incorporated by electrospinning into polymeric NFs for drug delivery applications and cancer treatments. In this review, we focus on the incorporation of drugs into polymeric NFs for drug delivery and cancer treatment applications. However, the principal novelty compared with previously reported publications is that we also focus on recent investigations concerning new strategies that increase drug delivery and cancer treatments efficiencies, such as the incorporation of colloidal nanoparticles into polymeric NFs, the possibility to fabricate NFs with the capability to respond to external environments, and finally, the synthesis of hybrid polymeric NFs containing carbon nanotubes, magnetic and gold nanoparticles, with magnetic and plasmonic hyperthermia applicability.

scholarly journals Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution

2020 ◽  
Vol 71 (4) ◽  
pp. 145-154 ◽  
Author(s):  
Iulian Antoniac ◽  
Alexandru Cernea ◽  
Cristian Petcu ◽  
Dan Laptoiu ◽  
Diana Tabaras ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
The Body ◽  
Osteoarthritis Of The Knee ◽  
Layer By Layer ◽  
Area Of Interest ◽  
Physico Chemical ◽  
Iron Oxide Magnetic Nanoparticles

Drug delivery systems enable transportation of drugs in the body, controlling the time, rate or place of the release rendering them ideal for local treatments. When treating joint diseases such as osteoarthritis of the knee the therapeutically substances are given intra-particularly. Magnetic nanoparticles are used so that the solution containing the treatment can be easily directed from the outside with the help of magnets allowing the drug to reach the maximum concentration at the area of interest. Functionalization of nanoparticles is necessary to obtain viscoelastic solutions with optimal physico-chemical and medical properties. This paper presents a superior method of delivering intraarticular hyaluronic acid using iron oxide magnetic nanoparticles (Fe2O3) which were embedded in tetramethylammonium hydroxide (TMOH) and coated using a layer-by-layer technique with hyaluronic acid and inulin. TMOH was chosen for a better dispersion of nanoparticles in the viscoelastic solution, eliminating the risk of agglomerations, hyaluronic acid and inulin being used for medical purposes.

scholarly journals Biocompatible Polymer Nanoparticles for Drug Delivery Applications in Cancer and Neurodegenerative Disorder Therapies

2019 ◽  
Vol 10 (1) ◽  
pp. 4 ◽  
Author(s):  
Eleonora Calzoni ◽  
Alessio Cesaretti ◽  
Alice Polchi ◽  
Alessandro Di Michele ◽  
Brunella Tancini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Neurodegenerative Disorder ◽  
The Body ◽  
Polymer Nanoparticles ◽  
Close Attention ◽  
Passive Targeting ◽  
Non Invasive ◽  
The Central Nervous System ◽  
Drug Delivery Applications ◽  
Experimental Strategies

Polymer nanoparticles (NPs) represent one of the most innovative non-invasive approaches for drug delivery applications. NPs main objective is to convey the therapeutic molecule be they drugs, proteins, or nucleic acids directly into the target organ or tissue. Many polymers are used for the synthesis of NPs and among the currently most employed materials several biocompatible synthetic polymers, namely polylactic acid (PLA), poly lactic-co-glycolic acid (PLGA), and polyethylene glycol (PEG), can be cited. These molecules are made of simple monomers which are naturally present in the body and therefore easily excreted without being toxic. The present review addresses the different approaches that are most commonly adopted to synthetize biocompatible NPs to date, as well as the experimental strategies designed to load them with therapeutic agents. In fact, drugs may be internalized in the NPs or physically dispersed therein. In this paper the various types of biodegradable polymer NPs will be discussed with emphasis on their applications in drug delivery. Close attention will be devoted to the treatment of cancer, where both active and passive targeting is used to enhance efficacy and reduce systemic toxicity, and to diseases affecting the central nervous system, inasmuch as NPs can be modified to target specific cells or cross membrane barriers.

Bioresponse Inspired Nanomaterials for Targeted Drug and Gene Delivery

2019 ◽  
Vol 7 (3) ◽  
pp. 220-233 ◽  
Author(s):  
Shrestha Sharma ◽  
Md. Noushad Javed ◽  
Faheem Hyder Pottoo ◽  
Syed Arman Rabbani ◽  
Md. Abul Barkat ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metallic Nanoparticles ◽  
Plasma Concentrations ◽  
The Body ◽  
Target Cells ◽  
Current Trends ◽  
Therapeutic Outcomes ◽  
Metabolic States ◽  
Traditional Drug ◽  
Specific Receptors

The traditional drug delivery techniques are unresponsive to the altering metabolic states of the body and fail to achieve target specific drug delivery, which results in toxic plasma concentrations. In order to harmonize the drug release profiles, diverse biological and pathological pathways and factors involved have been studied and consequently, nanomaterials and nanostructures are engineered in a manner so that they respond and interact with the target cells and tissues in a controlled manner to induce promising pharmacological responses with least undesirable effects. The bioinspired nanoparticles such as carbon nanotubes, metallic nanoparticles, and quantum dots sense the localized host environment for diagnosis and treatment of pathological states. These biocompatible polymeric- based nanostructures bind drugs to the specific receptors, which renders them as ideal vehicles for the delivery of drugs and gene. The ultimate goal of bioinspired nanocomposites is to achieve personalized diagnostic and therapeutic outcomes. This review briefly discussed current trends; role, recent advancements as well as different approaches, which are being used for designing and fabrication of some bioinspired nanocarriers.

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